Multimodel Phenotyping To Predict Oral Appliance Treatment Outcome In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$525,777.00
Summary
Obstructive sleep apnoea is a common sleep-related breathing disorder. Oral appliances worn during sleep to gently hold the lower jaw in a forward position are a novel treatment modality often appealing to patients. Currently use is limited as there is no means to determine if patients will be treated successfully. There is a need for simple, clinical methods to predict which patients are best suited to this new treatment approach and this project will address this by developing such a method.
The Landscape Of Cancer Genes And Associations With Prognosis In Breast Cancer Diagnosed In Premenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$700,512.00
Summary
Using state of the art technology, the purpose of this project is understand the implications of known cancer mutations in breast cancer diagnosed in premenopausal ER-positive breast cancer. Mutations are abnormalities in the DNA of genes that can provide a signal for uncontrolled growth, a hallmark of cancer. The unique aspect of this project is use of tissue samples from patients who were diagnosed with breast cancer at a young age. This information will help us develop new treatments.
Advancement Of A Personalised Approach To Minimising Infective Complications In Cancer Care
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Managing infections in patients with cancer have become more difficult and unpredictable because of new generation cancer therapies. Measuring the response of the immune system (immune profiling) will allow us to predict which patients will develop infection so that action such as vaccination can be taken to reduce their risk. This program will refine immune profiling to personalise infection care for cancer patients and to introduce it into hospital practice.
Predicting Infections In Cancer Of The Plasma Cells In Bone Marrow (myeloma)
Funder
National Health and Medical Research Council
Funding Amount
$107,764.00
Summary
The study will look for new risks for infection in patients with multiple myeloma, a cancer of plasma cells in the bone marrow. Currently these patients are expected to live longer because of the discovery and use of new generation cancer drugs. By finding new infection risks, the treatment of life threatening infections can be improved or infection can be prevented so patients have a better quality of life whilst on cancer treatment.
The Prediction And Prevention Of Caesarean Section For Slow Progress In Labour
Funder
National Health and Medical Research Council
Funding Amount
$227,261.00
Summary
8% of all births are by caesarean section (CS) for slow labour. Bringing on labour just before the due date reduces the chance of CS but we can’t do this for all women. We have a way to predict high risk of CS for slow labour to select women who may benefit from bringing on the labour. We will perform a study where the women at high risk have can have the labour brought on slightly early. The project could result in 6,000 fewer CSs in Australia alone and prevent many complications of CS.
Helping Stroke Physicians Choose Who To Thrombolyse - The Targeting Optimal Thrombolysis Outcomes (TOTO) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,073,140.00
Summary
Thrombolysis using alteplase is one of the most effective treatments for stroke but is currently used in only 5% of stroke cases. A major barrier is a lack of tools to identify who will benefit from treatment, or who might have a major adverse event. In this study we will develop a clinical decision rule based on clinical data, advanced CT imaging, and blood biomarkers to help identify those who will benefit and those likely to bleed, to encourage wider use of this treatment in acute stroke.
Brain Connectivity Imaging Markers To Confirm Diagnosis For Bipolar Vs. Unipolar Depression – A Connectome Approach.
Funder
National Health and Medical Research Council
Funding Amount
$434,369.00
Summary
Differentiating Bipolar disorders from Unipolar Depression is a major clinical challenge. This misdiagnosis hinders optimal clinical care and has many deleterious consequences such self-harm, increased chances of suicide, poor prognosis, and greater health care costs related to this disorder. This project will provide urgently-needed advance in accurate identification of Bipolar disorders using Magnetic Resonance Imaging and remove one of the key obstacles to accurate diagnosis.
Better Data To Inform Interventions To Reduce The Risk Of Stillbirth In Australia
Funder
National Health and Medical Research Council
Funding Amount
$75,830.00
Summary
Stillbirth is a devastating experience for parents and families. Paucity of high quality data on causes and contributing factors is a major barrier to the development of research priorities and interventions to prevent stillbirths and improve the quality of care. This research will be a connected body of work that aims to better describe the epidemiology of stillbirth in Australia, contribute to the classification of stillbirths and determine the needs of parents in relation to autopsy consent.