Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international effo ....Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international efforts in this area, via the development of statistical methods for segmenting genomes, classification of those segments, and study of the resulting classes. In the long term, enhanced understanding of eukaryotic cells will lead to breakthroughs in biology, and to medical, pharmaceutical, agricultural and scientific advances.Read moreRead less
New Approaches to the Analysis of Count Time Series. The focus of this proposal is on the analysis of data that enumerate events over time. Occurrences of such count data abound in economics and business, examples being observations on insurance claims, loan defaults and individual product demand. This project develops a suite of innovative methods for modelling and predicting event counts. The methods explicitly accommodate both the discreteness of the data and possible complexities in its evo ....New Approaches to the Analysis of Count Time Series. The focus of this proposal is on the analysis of data that enumerate events over time. Occurrences of such count data abound in economics and business, examples being observations on insurance claims, loan defaults and individual product demand. This project develops a suite of innovative methods for modelling and predicting event counts. The methods explicitly accommodate both the discreteness of the data and possible complexities in its evolution over time. In so doing, they enable both accurate inferences regarding the dynamic structure of the data to be drawn and accurate forecasts of future event counts to be produced.Read moreRead less
Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optim ....Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optimisation of Complex Systems.Read moreRead less
Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivota ....Non-invasive assessment of hip fracture risk in elderly people. No falls, no fractures - this will be the main benefit of the proposed research. The most significant outcome will be new computational tools to improve current understanding of the biomechanics of falls and bone fragility in elderly people, which, in turn, will help to reduce healthcare costs associated with the treatment and management of hip fractures. Realistic models and computer simulations of human movement can play a pivotal role in three of Australia's largest industries: healthcare, through the diagnosis and treatment of movement disorders; sports, through the development of personalized training programs for elite athletes; and entertainment, through the development of video/digital games and animated films.Read moreRead less
A Control Systems Approach for Understanding Human Locomotion. This proposal addresses fundamental, difficult questions in the context of human movement: How do muscles move our limbs during walking? How do the nervous system and muscles work together to control movement? Realistic computer simulations of human movement can help answer these questions and, in so doing, can play a pivotal role in three of Australia's largest industries: healthcare, through clinical gait analysis and gait rehabili ....A Control Systems Approach for Understanding Human Locomotion. This proposal addresses fundamental, difficult questions in the context of human movement: How do muscles move our limbs during walking? How do the nervous system and muscles work together to control movement? Realistic computer simulations of human movement can help answer these questions and, in so doing, can play a pivotal role in three of Australia's largest industries: healthcare, through clinical gait analysis and gait rehabilitation (diagnosis and treatment of movement disorders); sports, through the development of personalized training programs for elite athletes; and entertainment, through the development of video/digital games and animated films (creation of virtual life-like actors).Read moreRead less
Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity o ....Patient-specific computational tools for evaluating functional performance of total knee replacements in vivo. Knee replacement surgery is the established treatment for end-stage osteoarthritis. This proposal addresses one of the most fundamental questions related to knee replacement surgery: Why do total knee replacements fail? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the functional performance and longevity of current knee implant designs. Realistic computer simulations of human movement also can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Complexity in Algebra and Algebra in Complexity: the role of finite semigroups and general algebra. Algebra and logic form the mathematical framework for expressing and analysing algorithms and their difficulty. We can then scientifically analyse what makes some tasks more difficult than others. This project unifies parallel areas of algebra to focus on two key topics at this interface between algebra and computational complexity. As a flow on, our work can uncover new algorithms for solving ....Complexity in Algebra and Algebra in Complexity: the role of finite semigroups and general algebra. Algebra and logic form the mathematical framework for expressing and analysing algorithms and their difficulty. We can then scientifically analyse what makes some tasks more difficult than others. This project unifies parallel areas of algebra to focus on two key topics at this interface between algebra and computational complexity. As a flow on, our work can uncover new algorithms for solving constraint problems and for the study of formal languages.
With a team of top international researchers developing new interactions between mathematics and the study of algorithms, the project will foster a culture of innovation and bring Australia into the play in this internationally competitive area.Read moreRead less
New Geometric and Entropy Techniques for Differential Equations. The three main practical outcomes of this mathematical research will be better predictability of salt movement responsible for land degradation, better predictability of surface evolution of microelectronic components in nanoscale technology and an open source computer package that harnesses new and powerful geometrical techniques to solve differential equations. The project will train the next generation of researchers in the math ....New Geometric and Entropy Techniques for Differential Equations. The three main practical outcomes of this mathematical research will be better predictability of salt movement responsible for land degradation, better predictability of surface evolution of microelectronic components in nanoscale technology and an open source computer package that harnesses new and powerful geometrical techniques to solve differential equations. The project will train the next generation of researchers in the mathematical modelling of critical physical processes and it will bring international experts to Australia to work on these vital problems.Read moreRead less
Representation Theory: Path models and decompositions. The research in this proposal develops tools for capitalising on the benefits of symmetry in large complex systems. These techniques and processes are applicable for solving complex problems in large interactive systems. This project will involve young researchers and train them for problem solving in a wealth of fields, including management, the sciences, the financial industries, and the development of technologies. The research is in o ....Representation Theory: Path models and decompositions. The research in this proposal develops tools for capitalising on the benefits of symmetry in large complex systems. These techniques and processes are applicable for solving complex problems in large interactive systems. This project will involve young researchers and train them for problem solving in a wealth of fields, including management, the sciences, the financial industries, and the development of technologies. The research is in one of the most active cutting edge areas of pure mathematics and will contribute to maintaining Australia's position as a leading nationality in research in representation theory and its applications.
Read moreRead less
Adaptiveness of self-organised decision making. Complex systems are an important international research focus in many disciplines, and their engineering applications are plentiful. The new mathematical approach developed by this project will enable different disciplines for the first time to communicate using a common formal framework. This will open the path to a generalized understanding of self-organized systems in dynamic environments. Creating the tools for a unified interdisciplinary a ....Adaptiveness of self-organised decision making. Complex systems are an important international research focus in many disciplines, and their engineering applications are plentiful. The new mathematical approach developed by this project will enable different disciplines for the first time to communicate using a common formal framework. This will open the path to a generalized understanding of self-organized systems in dynamic environments. Creating the tools for a unified interdisciplinary approach will allow Australia to gain a stronger position in biomimetic engineering and to take a lead in international research on collective behavior.
Read moreRead less