Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. T ....Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. This framework will provide novel insights into how energetics, morphology, and habitat have shaped the evolution of this unique group. This may open doors to a range of future ecological, physiological, and conservation studies and provide biological inspiration for energetically efficient robotic and assistive devices.Read moreRead less
Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput ge ....Deciphering the regulatory principles of metazoan development. This proposal aims to elucidate how regulatory elements in the genome, known as enhancers, determine the identity and function of animal tissues. Currently, it is believed that enhancers cannot be traced across evolutionarily distant animals. The project uses novel concepts, computational and molecular approaches to identify deeply conserved enhancers. It further dissects the mechanism of function by proteomics and high-throughput genomics. The expected outcomes will overturn our current view on enhancer evolution and reposition our understanding of how enhancers are functionally encoded in the genome. The work is an important contribution to understanding cellular complexity and species evolution with wide-ranging impact in genetics.Read moreRead less
Visualising genetic mosaicism during development. Genetic diversity is the variation in DNA sequence among individuals. We now know that there are also differences in the DNA sequences of cells within the same individual, known as genetic mosaicism. The aims of this proposal are 1) to develop a system to visualise genetic mosaicism 2) arising during embryonic development and 3) in the brain, driven by mobile DNA activity. The expected outcome of this proposal is an unprecedented understanding of ....Visualising genetic mosaicism during development. Genetic diversity is the variation in DNA sequence among individuals. We now know that there are also differences in the DNA sequences of cells within the same individual, known as genetic mosaicism. The aims of this proposal are 1) to develop a system to visualise genetic mosaicism 2) arising during embryonic development and 3) in the brain, driven by mobile DNA activity. The expected outcome of this proposal is an unprecedented understanding of the scope and consequences of mobile DNA-driven mosaicism. This work will have significant impacts in developmental genetics and neurogenetics, and has the benefit of introducing an innovative experimental system with the potential to spark international scientific collaboration and recognition.Read moreRead less
Precision ecology: the modern era of designed experiments in plant ecology. This project aims to develop the field of precision ecology, forging a new era of designed experiments where sampling is informed by research questions and what is known about the ecological process being studied. Through the development of novel statistical methods, new experiments globally will be designed to answer important ecological questions including what influence abiotic and biotic factors have on plant commun ....Precision ecology: the modern era of designed experiments in plant ecology. This project aims to develop the field of precision ecology, forging a new era of designed experiments where sampling is informed by research questions and what is known about the ecological process being studied. Through the development of novel statistical methods, new experiments globally will be designed to answer important ecological questions including what influence abiotic and biotic factors have on plant communities over time and different spatial scales. Expected outcomes include new methods and tools that will modernise how future experiments will be conducted in plant ecology. This will provide significant transdisciplinary benefits including new statistical methods that target scientific discovery in ecological studies.Read moreRead less
The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child ....The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child protection, disability services, and aged care; assess the use of this research to the human services sector and its effect on generating innovation; and develop strategies to advance the production, uptake, and effect of social work research.Read moreRead less
Adjudicating rights for a sustainable National Disability Insurance Scheme. The aim of the National Disability Insurance Scheme is to redress unfairness for disabled Australians. The sensitive question for government and citizens is how to determine what support is fair? The goal is support based on the perceived needs and choices of individuals. The government is additionally concerned to ensure financial sustainability by limiting expectations about reasonable and necessary support. This proje ....Adjudicating rights for a sustainable National Disability Insurance Scheme. The aim of the National Disability Insurance Scheme is to redress unfairness for disabled Australians. The sensitive question for government and citizens is how to determine what support is fair? The goal is support based on the perceived needs and choices of individuals. The government is additionally concerned to ensure financial sustainability by limiting expectations about reasonable and necessary support. This project will identify the dominant operating principles and debates concerning funded support, by analysing relevant frameworks, decisions, appeals and internal reviews. By taking an administrative justice perspective, it contributes to a critical debate about the values guiding funded support decisions and fairness outcomes.Read moreRead less
Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects o ....Mapping the learning mechanisms linking adversity with maladjustment. Exposure to adversity, such as violence, neglect and natural disasters, is common and a powerful risk factor for emotional maladjustment. Yet knowledge of the underlying mechanisms linking adversity with emotional maladjustment is remarkably limited. By drawing from theories of adversity and learning and utilising novel experimental methodology, this project aims to map how adverse experiences have different negative effects on daily emotional wellbeing by disrupting the mechanisms underlying how people learn to acquire and reduce reactivity to new threats. Expected benefits include new knowledge about the pathways linking adversity with psychopathology as well as the vital evidence-base for clear targets for behavioural interventions. Read moreRead less
Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that t .... Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that the true nature of brain adaptation across the lifespan will be revealed. Findings which may then provide new opportunities to strengthen, maintain and optimise cognitive function.Read moreRead less
Optimal Fundraising Design in a Competitive Market: A Unifying Framework. Increased competition from over 57,000 registered charities and a recent 6% decrease in individual donations, have increased the need for charities to improve their fundraising strategies. This project aims to develop a comprehensive framework – based on theories from marketing, psychology, economics, sociology, and philanthropy— and develop novel methodologies to determine effective charitable fundraising strategies in ....Optimal Fundraising Design in a Competitive Market: A Unifying Framework. Increased competition from over 57,000 registered charities and a recent 6% decrease in individual donations, have increased the need for charities to improve their fundraising strategies. This project aims to develop a comprehensive framework – based on theories from marketing, psychology, economics, sociology, and philanthropy— and develop novel methodologies to determine effective charitable fundraising strategies in a competitive marketplace. Key outcomes will include the theoretical model, and tests using conjoint choice-experiments, controlled field experiments and 10 years of giving data from 4 million Australian donors. These outcomes will enhance fundraising practice, ensuring charities can better serve the Australian public.Read moreRead less