Structural domains of beta-tubulin and their role in microtubule dynamics and transport. This study aims to obtain a fundamental understanding of how the structural domains of the cytoskeletal protein beta-tubulin are involved in microtubule structures during cell division and vesicular transport. Using gene-editing technology and coupling this with cell biological approaches and high-resolution cell imaging will enable detailed analysis of the role of beta-tubulin domains in these important cel ....Structural domains of beta-tubulin and their role in microtubule dynamics and transport. This study aims to obtain a fundamental understanding of how the structural domains of the cytoskeletal protein beta-tubulin are involved in microtubule structures during cell division and vesicular transport. Using gene-editing technology and coupling this with cell biological approaches and high-resolution cell imaging will enable detailed analysis of the role of beta-tubulin domains in these important cellular processes. The outcomes will include fundamental new knowledge in cell biology and lead to the development of unique biological models that can be used to understand disease.Read moreRead less
Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spri ....Optimising the spring in your step to enhance footwear design. This project aims to examine how the nervous system adjusts the mechanical function of our feet across a spectrum of speeds, from slow running through to maximal effort sprinting. The proposed research will explore how the nervous system controls the function of the foot to meet the ever-varying demands of locomotion in the real-world. Expected outcomes of this project are to determine if running shoes help or hinder the natural spring-like function of the foot. It will explain a conceptually novel design allowing shoes to support our feet, whilst harnessing the energetic benefits of the foot's spring-like function. This research has the potential to revolutionise athletic footwear design and has direct implications for enhanced performance in running athletes.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Communicating to promote engagement in using electronic medical records. This reflexive ethnographic and co-design project aims to examine how patient and family participation occurs with health professionals in using the electronic medical record within hospitals, especially for patients with complex needs. Its significance involves working with patients and families to consider how they could take part in decision making activities across transitions of care and influence health care activitie ....Communicating to promote engagement in using electronic medical records. This reflexive ethnographic and co-design project aims to examine how patient and family participation occurs with health professionals in using the electronic medical record within hospitals, especially for patients with complex needs. Its significance involves working with patients and families to consider how they could take part in decision making activities across transitions of care and influence health care activities. Outcomes are new knowledge and practices about how communication occurs with the electronic medical record and strategies adopted for effective engagement. Benefits are increased understanding of how and under what circumstances, engagement can take place in using the electronic medical record.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100473
Funder
Australian Research Council
Funding Amount
$462,573.00
Summary
Breaking Performance Limits of Solar Inverters for a Sustainable Future. Micro-inverters offer a unique ability to maximise solar energy yield and streamline the installation, operation and maintenance process of solar power generation, thus having huge potentials to drastically reduce the cost of solar electricity. However, performance limits have hampered their wider applications in the energy sector. This project aims to tackle the performance challenges of micro-inverters by developing a nov ....Breaking Performance Limits of Solar Inverters for a Sustainable Future. Micro-inverters offer a unique ability to maximise solar energy yield and streamline the installation, operation and maintenance process of solar power generation, thus having huge potentials to drastically reduce the cost of solar electricity. However, performance limits have hampered their wider applications in the energy sector. This project aims to tackle the performance challenges of micro-inverters by developing a novel power-conversion architecture, a unified design framework, and a new control theory. The intended research outcome will be a new range of ultra-high-performance micro-inverters. This will promote greater solar uptake and maintain Australia’s leadership in the development of disruptive solar power generation technology.Read moreRead less
Need for Speed: Towards Controller Design Automation for Power Electronics. This project aims to address the need for advanced controller design automation tools for power electronics systems by advocating a novel design paradigm. The project expects to seek breakthroughs in the modelling and optimisation aspects of power electronics systems and generate new automation tools for existing and emerging power electronics applications. Expected outcome include significant reduction of controller dev ....Need for Speed: Towards Controller Design Automation for Power Electronics. This project aims to address the need for advanced controller design automation tools for power electronics systems by advocating a novel design paradigm. The project expects to seek breakthroughs in the modelling and optimisation aspects of power electronics systems and generate new automation tools for existing and emerging power electronics applications. Expected outcome include significant reduction of controller development cycle time and cost, minimisation of human oversight, and maximisation of system performance. Profound benefits include maintaining Australia’s leadership in a wide range of sectors such as renewable energy and electric vehicles demanding rapid development cycles and realisation of Australia’s zero-carbon vision. Read moreRead less