A New Target For Allergic Inflammation: The Sphingolipid Pathway
Funder
National Health and Medical Research Council
Funding Amount
$588,617.00
Summary
Collectively, allergic diseases contribute immensely to the burden of health care in Australia. Notably, allergic reactions are symptomatic responses to a normally innocuous environmental antigen. Allergic diseases include asthma, hay fever, food allergy, anaphylaxis, insect sting and drug allergy. This project aims to understand the underlying mechanisms associated with allergic reactions such that it may aid in the identification of novel targets for the development of new treatments.
Role Of Zinc In The Respiratory Epithelium And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example ....This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example, asthma affects 12% of adults and amongst these, 15% waken weekly or more often with their asthma while 6% are hospitalized annually. There is a need to understand the basic mechanisms underlying these diseases so that new strategies can be developed to modify bronchocondtriction and inflammation. The project will provide new knowledge concerning the physiology of Zn in the respiratory epithelium and interactions between Zn deficiency and oxidants on injury in the respiratory tract. The usefulness of easily accessible nasal epithelial cells as a measure of Zn and Zn transporter levels deeper in the respiratory tract will be assessed. The project encompasses a number of fields and utilizes in vitro cellular and animal models, as well as tissues from human subjects.Read moreRead less
Electronic and Optical Properties of Doped Titanium Dioxide. Titanium dioxide, is widely used as a white pigment, owing to its high refractive index, second, only after diamond. Yellowing of rutile pigment particles, observed on prolonged exposure to sunlight, is a serious problem that pigment manufacturers would like to overcome. It is proposed that aluminium-doping of rutile limits this discolouration by altering the electronic structure of the rutile particles. This project seeks to identify ....Electronic and Optical Properties of Doped Titanium Dioxide. Titanium dioxide, is widely used as a white pigment, owing to its high refractive index, second, only after diamond. Yellowing of rutile pigment particles, observed on prolonged exposure to sunlight, is a serious problem that pigment manufacturers would like to overcome. It is proposed that aluminium-doping of rutile limits this discolouration by altering the electronic structure of the rutile particles. This project seeks to identify the specific electronic cause of the yellowing process, the nature of the Al defect,it's effect on the electronic structure of rutile, and the electronic perturbations that may occur when other dopants are used.Read moreRead less
Structural and functional investigations of the human transcription machinery by ion mobility-mass spectrometry. This project will apply emerging mass spectrometric technologies to gain previously inaccessible insight into human transcription factor proteins. This will reveal new avenues for intervention in human disease states related to aberrant gene expression, while developing innovative methods for the study of complex protein assemblies.
Development of efficient, robust and architecturally-flexible structural systems using innovative blind-bolted connections. The aim of the proposed project is to develop structural systems that have sufficient stiffness, strength, and ductility to withstand code-specified loads and that will be competitive in the marketplace. The development of demonstrable cost-effective structural systems is essential if these types of systems are to be widely adopted in practice, thus allowing Australian manu ....Development of efficient, robust and architecturally-flexible structural systems using innovative blind-bolted connections. The aim of the proposed project is to develop structural systems that have sufficient stiffness, strength, and ductility to withstand code-specified loads and that will be competitive in the marketplace. The development of demonstrable cost-effective structural systems is essential if these types of systems are to be widely adopted in practice, thus allowing Australian manufacturers of blind bolts and steel tubes to achieve a greater market share.Read moreRead less
Fibre reinforced polymer retrofitting of reinforced concrete flexural members. A cost-effective and durable technique for retrofitting reinforced concrete beams and slabs is to adhesively bond new advanced fibre reinforced polymer (FRP) composites to their surfaces. The potential plating market in Australia for bridges is $350 million, however, the technique can also be applied to strengthening other structures such as buildings. Tests have shown that FRP plates or sheets can debond prematurely, ....Fibre reinforced polymer retrofitting of reinforced concrete flexural members. A cost-effective and durable technique for retrofitting reinforced concrete beams and slabs is to adhesively bond new advanced fibre reinforced polymer (FRP) composites to their surfaces. The potential plating market in Australia for bridges is $350 million, however, the technique can also be applied to strengthening other structures such as buildings. Tests have shown that FRP plates or sheets can debond prematurely, which at present severely limits the application. The aim of this research project is to quantify the debonding mechanisms, strengths and ductilities of adhesively bonded FRP plated beams to provide design rules that can be used in practice.Read moreRead less
Earthquake protection of masonry buildings using fibre reinforced polymer strengthening. The importance of this research is highlighted, both nationally and internationally, by the work of the insurance industry which reported that the economic risk posed by a moderate earthquake in any of the capital cities in Australia is of the order of billions of dollars (Blong, 1993). For example, a 'design magnitude' earthquake in Sydney is predicted to cause, just in domestic construction, over $10 bill ....Earthquake protection of masonry buildings using fibre reinforced polymer strengthening. The importance of this research is highlighted, both nationally and internationally, by the work of the insurance industry which reported that the economic risk posed by a moderate earthquake in any of the capital cities in Australia is of the order of billions of dollars (Blong, 1993). For example, a 'design magnitude' earthquake in Sydney is predicted to cause, just in domestic construction, over $10 billion damage and more than 5000 deaths. Most of this damage would be associated with unreinforced masonry construction such as low-rise apartment buildings. The damage bill for the entire built environment (with business interruption costs) could easily be an order of magnitude greater.Read moreRead less
Blast resistance of flexural ultra-high performance concrete members. Ultra high performance concrete (UHPC) has high material strengths, high material deformation and high toughness, making it an ideal material for resisting blast effects. Since there are great differences between the mechanical properties of UHPC and conventional concrete, traditional guidelines need to be significantly adapted to accommodate UHPC. This project will facilitate the development of design procedures for reinforce ....Blast resistance of flexural ultra-high performance concrete members. Ultra high performance concrete (UHPC) has high material strengths, high material deformation and high toughness, making it an ideal material for resisting blast effects. Since there are great differences between the mechanical properties of UHPC and conventional concrete, traditional guidelines need to be significantly adapted to accommodate UHPC. This project will facilitate the development of design procedures for reinforced UHPC members. It will enable design engineers to take advantage of the desirable properties of UHPC for anti-terrorism. The application of this project will lead to saving lives, reducing the extent of injury and minimizing social and economic disruption.Read moreRead less
Ductile FRP retrofit of concrete frames subject to static and earthquake loading. Australia needs to spend at least $500 million annually on the repair and upgrading of concrete structures alone just to maintain our existing civil infrastructure. Furthermore, it has been estimated that more than 500 deaths and $10 billion damage will be caused by a moderate earthquake in Sydney or Melbourne. Most of this damage will be due to the collapse of buildings. This research will develop a new form of ....Ductile FRP retrofit of concrete frames subject to static and earthquake loading. Australia needs to spend at least $500 million annually on the repair and upgrading of concrete structures alone just to maintain our existing civil infrastructure. Furthermore, it has been estimated that more than 500 deaths and $10 billion damage will be caused by a moderate earthquake in Sydney or Melbourne. Most of this damage will be due to the collapse of buildings. This research will develop a new form of ductile plating that will reduce the cost of retrofitting concrete bridges and buildings. This project will also help train two PhD students and one Research Associate and further enhance the existing collaboration between Australia and Italy.Read moreRead less