Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Delineating The Relationship Between Iron And Peroxisomal Disorders: The Role Of The Peroxisomal Enzyme GNPAT In Iron-Overload Disorders
Funder
National Health and Medical Research Council
Funding Amount
$700,767.00
Summary
Hereditary haemochromatosis is one of the most common genetic disorders in humans, affecting 1 in 200 Australians. We have identified a change in a peroxisomal gene which may affect iron levels in humans. The prevalence of this gene change in Australian haemochromatosis patients will be examined followed by a systematic analysis of how this protein controls iron levels in the body. Our goal is to identify and diagnose genetic changes which influence iron loading in haemochromatosis patients.
Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for ....Structural behaviour of innovative hollow flange steel members subject to local and lateral distortional buckling effects. This project will investigate the local and lateral distortional buckling behaviour of a new generation of innovative and cost-effective thin and high strength steel hollow flange sections (HFS) being developed using a unique dual weld and roll-forming technology. It will use experiments and advanced numerical modelling to develop fundamental behavioural and design data for HFS flexural members. Effects of web corrugations and punched holes will also be investigated. The research will enable innovative applications using HFS in the building industry in Australia and overseas. It will bring significant economic benefits to the industry partner, steel building industry, and Australia.Read moreRead less
Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections a ....Structural Behaviour of Innovative LiteSteel Beams, their Design Improvements and Applications. This project will develop a significant knowledge base, accurate design models and innovative application methods for the new LSB, which will be fully used by the collaborating partner in marketing them in Australia and overseas. Both construction and manufacturing industry sectors will benefit through the increased use of the innovative and lightweight hollow flange sections. Using the new sections and the wealth of design information from this research, Australian engineers can develop cost-effective and safer building systems. Community at large, in particular rural and regional communities will gain through cheaper building systems, additional employment in LSB manufacturing and design, and opportunities locally and overseas.Read moreRead less
SARA: Delineating Its Association With The Onset And Development Of Liver Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$865,972.00
Summary
Liver disease, a significant burden on society, affects many in the prime of their life. Scarring of the liver is a response to injury due to many factors including alcohol, viruses, obesity, and fatty-liver disease. We have identified a protein associated with liver injury. In this project we will perform a systematic analysis to understand the role of this protein in injury progression. Ultimately we intend to develop tools to prevent and treat liver injury.
Understanding the performance of cold-formed steel frame wall systems in fires to design for superior fire resistance. This project will develop new light gauge steel frame (LSF) wall systems with superior fire resistance rating and associated design rules to enable innovative and safe applications of these wall systems in various building applications. This will enable expansion of the worldwide market for LSF wall systems by the industry partner.
Innovative and safe design solutions for aluminium façade systems. This project plans to develop design rules and mullion profiles to support the use of façades using aluminium members with complex shapes. The façade is of great importance to the structural safety, energy efficiency and aesthetics of a building. Commonly used façade systems are made of glass supported by aluminium mullions with complex shapes. Current aluminium design standards do not consider the instability and failures caused ....Innovative and safe design solutions for aluminium façade systems. This project plans to develop design rules and mullion profiles to support the use of façades using aluminium members with complex shapes. The façade is of great importance to the structural safety, energy efficiency and aesthetics of a building. Commonly used façade systems are made of glass supported by aluminium mullions with complex shapes. Current aluminium design standards do not consider the instability and failures caused by wind actions on facades using such complex aluminium members. This project aims to conduct full-scale tests and develop advanced numerical models to resolve several critical problems and identify designs with superior wind resistance. Based on this, the project aims to provide innovative, accurate and safe design rules for the façade engineering profession and building industry.Read moreRead less
Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes in ....Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes include new design models for wind, bushfire and cold-formed-steel Standards. This will significantly improve the bushfire safety of buildings, since non-combustible steel roof and wall systems are used as building envelopes in bushfire prone areas, but are not designed to withstand recently discovered bushfire-enhanced winds.Read moreRead less