Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The stud ....Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The study of this transport process will be important for understanding disorders like epilepsy and other disorders affecting neuronal excitability.Read moreRead less
Boron nitride nanotubes for tunable conductivity. The proposed research in nanotubes falls into the national research priority areas of advanced materials and breakthrough science. This ANU research group has a leading role in Boron Nitride (BN) nanotube research internationally. The proposed collaborative research will enhance this position and further improve the nation's research profile in nanotechnology. New intellectual properties will be generated if the project is successful, which wi ....Boron nitride nanotubes for tunable conductivity. The proposed research in nanotubes falls into the national research priority areas of advanced materials and breakthrough science. This ANU research group has a leading role in Boron Nitride (BN) nanotube research internationally. The proposed collaborative research will enhance this position and further improve the nation's research profile in nanotechnology. New intellectual properties will be generated if the project is successful, which will benefit the commercialization activity of BN nanotubes at ANU. New PhD and undergraduate students will be trained by the proposed cutting edge research project.Read moreRead less
Structure-property correlation in metal-oxide aerogels. Aerogels are truly remarkable materials with unique physical properties including extraordinary thermal insulation capabilities. The influence of mechanical deformation on these nanoscale materials is only poorly understood, despite key technological interest. This project aims to measure the response of a variety of aerogels samples to forces applied by nanoindentation and, using advanced electron microscopy and ion-beam analysis techniqu ....Structure-property correlation in metal-oxide aerogels. Aerogels are truly remarkable materials with unique physical properties including extraordinary thermal insulation capabilities. The influence of mechanical deformation on these nanoscale materials is only poorly understood, despite key technological interest. This project aims to measure the response of a variety of aerogels samples to forces applied by nanoindentation and, using advanced electron microscopy and ion-beam analysis techniques, to directly identify the atomic-level deformation mechanisms.Read moreRead less
Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the ....Correlation between surface force and morphology of self-assembled monolayer. As a most potential solid support for biological molecules without denaturing their functions, gold thiol self-assembled monolayers (SAMs) have been studied extensively for surface fabrication. In this project we will prepare functional monolayers using newly synthesized thiol derivatives, evaluate correlation between surface force and surface morphology of the SAMs using the surface forces apparatus, and optimize the condition to fabricate biological devices such as immune sensors.Read moreRead less
Positron processes - From Basic to Applied Science. Australian scientists are at the forefront of international activities in atomic and molecular physics and materials science research. This program will expand the level of expertise in an emerging field that has importance in both these areas - the use of positron beams. Australia is developing a new and exciting capacity for positron research through the National Positron Beamline Facility. Scientists in this collaboration will work with o ....Positron processes - From Basic to Applied Science. Australian scientists are at the forefront of international activities in atomic and molecular physics and materials science research. This program will expand the level of expertise in an emerging field that has importance in both these areas - the use of positron beams. Australia is developing a new and exciting capacity for positron research through the National Positron Beamline Facility. Scientists in this collaboration will work with other outstanding, international research groups in the field of positron studies to stimulate new directions for their research. The international links, and the novel capabilities of the new Australian Facility, will enable our researchers to fully exploit this new field of research.Read moreRead less
Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~ ....Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~30% of the population is infected with T. gondii and the occurrence of congenital toxoplasmosis is 0.2% of live births, which translates to roughly 500 cases/year. Our research will identify structural proteins in Toxoplasma cyst walls that will lead to the design of new strategies to control the diseases caused by these parasites.Read moreRead less
Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work ....Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work and simultaneously measure the very small forces that the machines generate. This will give Australian scientists access to a new technology for studying molecular machines.Read moreRead less