The structure and geochemistry of mineral interfaces in Earth's mantle. The interfaces between mineral grains are critical in determining rock properties and behaviour, yet we know little about them. This project uses emerging nano-technologies to establish the structure, chemistry and energy characteristics of interfaces in rocks from Earth’s mantle that control fundamental Earth processes such as plate tectonics and melting. The expected outcomes include a new understanding on one of the funda ....The structure and geochemistry of mineral interfaces in Earth's mantle. The interfaces between mineral grains are critical in determining rock properties and behaviour, yet we know little about them. This project uses emerging nano-technologies to establish the structure, chemistry and energy characteristics of interfaces in rocks from Earth’s mantle that control fundamental Earth processes such as plate tectonics and melting. The expected outcomes include a new understanding on one of the fundamental controls on rock properties and an enhanced ability to predict and model rock behaviour. The project provides research training in innovative research methodologies, will strengthen Australia’s leadership in nano-geoscience and will provide new methodologies for advanced rock characterisation.Read moreRead less
Defects and Deformation in Olivine: From Molecules to Mantle. This project establishes the role of hydrogen in controlling olivine deformation, plate tectonics and mantle geodynamics. The unique application of innovative nanoscale simulation, microscale observation and geophysical characterisation ensures that results will have far-reaching impact in the Australian and International Earth Science community. In particular, our results will enable greater understanding of water migration in the m ....Defects and Deformation in Olivine: From Molecules to Mantle. This project establishes the role of hydrogen in controlling olivine deformation, plate tectonics and mantle geodynamics. The unique application of innovative nanoscale simulation, microscale observation and geophysical characterisation ensures that results will have far-reaching impact in the Australian and International Earth Science community. In particular, our results will enable greater understanding of water migration in the mantle, the formation of deep Earth mineral resources and lead to significant improvements in the interpretation of geophysical variations in Earth's lithosphere.Read moreRead less
The Effects of Crystal-Plastic Deformation on Zircon Geochemical Systems. This project establishes the significance of deformation-related fast-diffusion pathways on the zircon geochemical system and develops intragrain compositional variations as new tools for tracking geological processes. The unique application of zircon to constrain geological processes in numerous Earth Science disciplines over 4.4 billion years of Earth history ensures that results will have far-reaching impact in the Aust ....The Effects of Crystal-Plastic Deformation on Zircon Geochemical Systems. This project establishes the significance of deformation-related fast-diffusion pathways on the zircon geochemical system and develops intragrain compositional variations as new tools for tracking geological processes. The unique application of zircon to constrain geological processes in numerous Earth Science disciplines over 4.4 billion years of Earth history ensures that results will have far-reaching impact in the Australian and International Earth Science community. As such this project will maintain Australia's leading international reputation in accessory mineral research.Read moreRead less
A virtual exploration of iron-sulphur-world in search of the precursors to life on earth. The greenhouse gas, carbon dioxide, that currently presents a threat to the continued existence of humanity, ironically represents the starting point from which life on Earth probably originated. This research will probe the chemistry of how this gas, dissolved in ancient oceans, came to be converted to molecules that form the basis of living organisms through interaction with minerals, such as iron sulphid ....A virtual exploration of iron-sulphur-world in search of the precursors to life on earth. The greenhouse gas, carbon dioxide, that currently presents a threat to the continued existence of humanity, ironically represents the starting point from which life on Earth probably originated. This research will probe the chemistry of how this gas, dissolved in ancient oceans, came to be converted to molecules that form the basis of living organisms through interaction with minerals, such as iron sulphide. Aside from answering a fundamental question, it will offer insights into processes that convert a pollutant into a useful chemical, as well as what might happen if carbon dioxide is placed in mineral deposits for long-term storage.Read moreRead less
A portable RNA-editing machine. Many plants maintain an elaborate RNA-editing machine that allows them to correct accumulated errors in their organellar genomes by specifically editing the RNA transcripts of the affected genes. A portable and adaptable version of this molecular machine would have significant biotechnological value, providing the ability to correct genetic errors, and to intervene in gene regulation without permanently altering a genome. The project aims to combine molecular and ....A portable RNA-editing machine. Many plants maintain an elaborate RNA-editing machine that allows them to correct accumulated errors in their organellar genomes by specifically editing the RNA transcripts of the affected genes. A portable and adaptable version of this molecular machine would have significant biotechnological value, providing the ability to correct genetic errors, and to intervene in gene regulation without permanently altering a genome. The project aims to combine molecular and structural biology approaches to fully characterise the components of the machine, thus allowing us to reconstitute it in cell-free systems and ultimately in other organisms.Read moreRead less
A structural investigation into T cell signalling machines. The project aims to understand how receptor recognition events cause intracellular signalling.Membrane-bound receptors, their cognate ligands and the ensuing intracellular activation signal determine cellular fate. The project will explore events central to cellular immunity by examining the T cell signalling machinery. This project will use labelling, crystallographic and cryo-electron microscopy studies, to determine the molecular arc ....A structural investigation into T cell signalling machines. The project aims to understand how receptor recognition events cause intracellular signalling.Membrane-bound receptors, their cognate ligands and the ensuing intracellular activation signal determine cellular fate. The project will explore events central to cellular immunity by examining the T cell signalling machinery. This project will use labelling, crystallographic and cryo-electron microscopy studies, to determine the molecular architecture of the T cell receptor (TCR) CD3 complex, a molecular machine central to T cell signalling. This project should reveal how antigen recognition leads to T cell signal transduction which will create jobs, bring substantial health benefits and improve quality of life for Australians.Read moreRead less
A structural and molecular investigation into the basic mechanism of T cell receptor complex function. Cellular fate is determined by interactions between membrane-bound receptors and their cognate ligands. The basic mechanism of how such receptor-mediated recognition events cause intracellular signalling is poorly understood in most biological systems, including the cellular immune recognition axis. This project will explore events central to cellular immunity by examining the interactions cent ....A structural and molecular investigation into the basic mechanism of T cell receptor complex function. Cellular fate is determined by interactions between membrane-bound receptors and their cognate ligands. The basic mechanism of how such receptor-mediated recognition events cause intracellular signalling is poorly understood in most biological systems, including the cellular immune recognition axis. This project will explore events central to cellular immunity by examining the interactions centred on T-cell receptor complexes. This project will explore the molecular mechanisms underpinning these key receptor-recognition events and relate these observations to T-cell activation. The proposal will shed fundamental insight into Major Histocompatibility Complex restriction, T-cell development and how antigen recognition leads to T-cell signal transduction. Read moreRead less
Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to corre ....Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.