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Effectiveness Of Training Somatosensation In The Hand After Stroke: A Randomized Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$180,660.00
Summary
Stroke is a leading cause of death and disability, requiring provision of rehabilitation services to help minimize impairment and its impact on the ability to resume daily activities. The ability to feel textures and objects through touch and to know where one s limbs are in space are impaired in up to 85% of people who have suffered a stroke. People with this loss are handicapped by difficulties in exploring objects through touch and in performing everyday tasks that require grasp and manipulat ....Stroke is a leading cause of death and disability, requiring provision of rehabilitation services to help minimize impairment and its impact on the ability to resume daily activities. The ability to feel textures and objects through touch and to know where one s limbs are in space are impaired in up to 85% of people who have suffered a stroke. People with this loss are handicapped by difficulties in exploring objects through touch and in performing everyday tasks that require grasp and manipulation of objects. Yet clinicians are either not treating the problem or are using methods without a sound theoretical basis and controlled evidence to support their application. We have systematically investigated optimal methods of sensory training across different sensory abilities using a series of single-subject experiments. Marked improvement in the ability to discriminate trained and related untrained texture stimuli and limb positions was achieved and maintained in most participants. These findings have provided the foundation for development a scientifically based and clinically focused sensory retraining program that has apparently excellent therapeutic potential. The purpose of the proposed study is to test the effectiveness of this scientifically based, clinical sensory retraining program in a broad group of stroke clients using the internationally recommended randomized controlled group design. The program will train a range of functionally important sensory discrimination tasks, i.e. texture discrimination, limb position sense and tactual object recognition, in clinical and home environments. Demonstration of clinically important and statistically significant training effects will provide the evidence necessary to recommend the introduction of the program into routine health service delivery. Investigation of patient characteristics that may impact on the ability to benefit from training will assist in the targeting of services to appropriate individuals.Read moreRead less
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
Centre For Research Excellence In Stroke Rehabilitation And Brain Recovery
Funder
National Health and Medical Research Council
Funding Amount
$2,595,746.00
Summary
The Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery will transform the stroke research and practice landscape in Australia, and accelerate the development of new interventions strongly supported by neuroscience. This unique collaboration will improve patient selection and rehabilitation research methods, create a training culture for the next generation of rehabilitation researchers and effectively implement proven cost effective interventions for Australians.
Translating Science Into Treatment For Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
My team has pioneered research in Australia that has advanced knowledge in the delivery of safer and more effective stroke therapies. I have developed software for the automated processing of multimodal CT imaging to better select patients for stroke therapies. In order to move this cutting-edge imaging technology into routine clinical practice several processes will occur: Implementation, validation and demonstration of patient benefits, and cost effectiveness of CT imaging selection in routine
Advanced Imaging For Patient Profiling In Patients With Stroke
Funder
National Health and Medical Research Council
Funding Amount
$319,831.00
Summary
Stroke is the leading cause of adult disability in the developed world. Many patients are require rehabilitation which can vary in terms of its success, and in many cases patients can be left with permanent and significant disability. Approaches to understand the neuroplastic changes associated with poststroke motor impairment are limited. This study aims to further our understanding of stroke recovery by undertaking a longitudinal MRI assessment of patients recovering from stroke.
Healthy Living After Stroke: An Online Intervention For Improving Stroke Survivor Health Behaviours And Quality Of Life
Funder
National Health and Medical Research Council
Funding Amount
$590,958.00
Summary
This study will test whether an online healthy lifestyles program helps survivors of stroke to live healthier lives, improve their quality of life and prevent a second stroke.
COMPARE- Constraint Induced Or Multi-Modal Aphasia Rehabilitation: An RCT Of Therapy For Stroke Related Chronic Aphasia
Funder
National Health and Medical Research Council
Funding Amount
$1,035,668.00
Summary
COMPARE is a 3 arm national randomised controlled trial comparing two types of intensive speech pathology treatment to usual care, for people with language disability 6 months to 3 years following stroke. After stratification by aphasia severity, participants are randomised to Multi-modality Aphasia Therapy, Constraint Induced Aphasia Therapy, or usual care. Cognitive, language, and speech assessments at baseline will enable sophisticated predictors of treatment responsiveness to be defined.
An Australasian, Multi-centre, Randomized, Double-blind, Placebo-controlled Trial Of The Efficacy Of Fluoxetine In Improving Functional Recovery After Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,306,367.00
Summary
Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.
Optimising Upper Limb Recovery Following Stroke: A Randomised Controlled Trial Of The Effects Of Botulinum Toxin-A Combined With Intensive Rehabilitation Compared To Botulinum Toxin-A Alone
Funder
National Health and Medical Research Council
Funding Amount
$1,070,230.00
Summary
The devastating loss of movement in the hand after stroke could potentially be addressed, but we currently lack of research investigating treatment interventions. This randomised controlled trial will compare the routine interventions of botulinum toxin to botulinum toxin plus best-practice therapy for both cost and clinical outcome. Findings from this trial will provide the necessary information to make decisions about what will improve spasticity and function in the hand and arm after stroke.