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Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
An Australasian, Multi-centre, Randomized, Double-blind, Placebo-controlled Trial Of The Efficacy Of Fluoxetine In Improving Functional Recovery After Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,306,367.00
Summary
Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.
I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Ecosystem restoration of bauxite-processing residue sand disposal areas in Western Australia: Important biogeochemical processes and effective fertilisation strategies. Alumina production is one of Australia's most important mining activities. Residue from bauxite-processing must be managed appropriately to minimise detrimental impacts on the surrounding environment. The location of Alcoa's WA Refineries in environmentally- and community- sensitive areas necessitates a detailed understanding of ....Ecosystem restoration of bauxite-processing residue sand disposal areas in Western Australia: Important biogeochemical processes and effective fertilisation strategies. Alumina production is one of Australia's most important mining activities. Residue from bauxite-processing must be managed appropriately to minimise detrimental impacts on the surrounding environment. The location of Alcoa's WA Refineries in environmentally- and community- sensitive areas necessitates a detailed understanding of residue disposal area (RDA) management. Currently little is known about the biogeochemical cycling of nitrogen, phosphorus and carbon in the residue sand despite its importance for sustainable rehabilitation practice. Findings from this project are critical for developing improved fertilisation strategies and protocols for ecosystem restoration of RDAs, which will be applicable both in Australia and overseas. Read moreRead less
Novel strategy for optimising fertilizer input coupled with organic residue management for sustainable reconstruction of jarrah forest ecosystem. This project is aimed at judicious management of the rehabilitation process following surface mining by reducing initial fertilizer input along with using organic residue accumulated following pre-mine clearing of vegetation. This approach has the potential for 'speeding-up' the ecosystem development process by initiating early microbial development in ....Novel strategy for optimising fertilizer input coupled with organic residue management for sustainable reconstruction of jarrah forest ecosystem. This project is aimed at judicious management of the rehabilitation process following surface mining by reducing initial fertilizer input along with using organic residue accumulated following pre-mine clearing of vegetation. This approach has the potential for 'speeding-up' the ecosystem development process by initiating early microbial development in rehabilitation practice and reducing the deleterious effect of heavy fertilization. Apart from these ecological advantages, reducing fertilizer application lowers minesite rehabilitation cost incurred by mining companies. This project will be the first attempt to use organic residue and streamlining the use of mineral fertilizers in mine rehabilitation practice.Read moreRead less
Ecosystem Assembly in Old Fields in the Western Australian Wheatbelt. This project aims to examine the process of ecosystem re-assembly on land which is taken out of agricultural production and left without further management. Land abandonment is common in many parts of the world and could increase dramatically in Australia due to land degradation, salinity and structural change. We will investigate the factors which influence whether native plant species can recolonise abandoned farmland, usin ....Ecosystem Assembly in Old Fields in the Western Australian Wheatbelt. This project aims to examine the process of ecosystem re-assembly on land which is taken out of agricultural production and left without further management. Land abandonment is common in many parts of the world and could increase dramatically in Australia due to land degradation, salinity and structural change. We will investigate the factors which influence whether native plant species can recolonise abandoned farmland, using field and greenhouse studies. We will do this within the context of ecosystem assembly, thereby answering a practical question and also providing input to a conceptual area which is currently of great interest inRead moreRead less
Improved quality and interpretation of terrestrial fauna surveys for environmental impact assessments in the mining industry. This study will improve the quality and interpretation of the terrestrial fauna surveys used as a basis for Environmental Impact Assessment in the mining industry. As a consequence, the Environment Protection Authority will better understand the potential impacts of mining on biodiversity and ecosystems, and can place more appropriate conditions on mining companies and th ....Improved quality and interpretation of terrestrial fauna surveys for environmental impact assessments in the mining industry. This study will improve the quality and interpretation of the terrestrial fauna surveys used as a basis for Environmental Impact Assessment in the mining industry. As a consequence, the Environment Protection Authority will better understand the potential impacts of mining on biodiversity and ecosystems, and can place more appropriate conditions on mining companies and their rehabilitation programs. In addition, the study will report on strategies for detecting rare and endangered species, and the development of appropriate databases to enable terrestrial fauna data to be interpreted in the context of soils and vegetation at habitat, landscape and regional scales.Read moreRead less
Investigation of the metabolism, molecular targets and environmental fate of the seed germination stimulant, butenolide. The potent germination stimulant, known as butenolide, is expected to provide substantial benefits for improving seed germination and seedling vigour of many plant species used in agriculture, land restoration and rehabilitation. Currently, little is known about the stability, persistence and distribution of the butenolide in natural environments and the mechanism of seed dorm ....Investigation of the metabolism, molecular targets and environmental fate of the seed germination stimulant, butenolide. The potent germination stimulant, known as butenolide, is expected to provide substantial benefits for improving seed germination and seedling vigour of many plant species used in agriculture, land restoration and rehabilitation. Currently, little is known about the stability, persistence and distribution of the butenolide in natural environments and the mechanism of seed dormancy breaking. This study now provides a unique opportunity for Australian research to establish a world-leading position in understanding the processes that regulate seed dormancy, particularly in relation to post-mining land rehabilitation. The research findings will also have wider application in plant conservation, weed control and crop production.Read moreRead less
A molecular ecophysiological assessment of the importance of using local provenance seed in plant biodiversity restoration. The rehabilitation of Australia's unique plant diversity, following disturbance, is an increasingly important activity nationally, involving industry, government and community. The use of local seeds is recognised as best practise, but how local is local? We will use molecular tools to identify the extent of local seed transfer zones, conduct trials to assess the relative ....A molecular ecophysiological assessment of the importance of using local provenance seed in plant biodiversity restoration. The rehabilitation of Australia's unique plant diversity, following disturbance, is an increasingly important activity nationally, involving industry, government and community. The use of local seeds is recognised as best practise, but how local is local? We will use molecular tools to identify the extent of local seed transfer zones, conduct trials to assess the relative performance of local and non-local seeds (is there a home-site advantage?), and assess the consequences of mixing provenances for future generations. We will work closely with industry and community restoration practitioners to improve the effectiveness of restoration, with benefits flowing nationally through general provenance guidelines.Read moreRead less