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Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
A molecular ecophysiological assessment of the importance of using local provenance seed in plant biodiversity restoration. The rehabilitation of Australia's unique plant diversity, following disturbance, is an increasingly important activity nationally, involving industry, government and community. The use of local seeds is recognised as best practise, but how local is local? We will use molecular tools to identify the extent of local seed transfer zones, conduct trials to assess the relative ....A molecular ecophysiological assessment of the importance of using local provenance seed in plant biodiversity restoration. The rehabilitation of Australia's unique plant diversity, following disturbance, is an increasingly important activity nationally, involving industry, government and community. The use of local seeds is recognised as best practise, but how local is local? We will use molecular tools to identify the extent of local seed transfer zones, conduct trials to assess the relative performance of local and non-local seeds (is there a home-site advantage?), and assess the consequences of mixing provenances for future generations. We will work closely with industry and community restoration practitioners to improve the effectiveness of restoration, with benefits flowing nationally through general provenance guidelines.Read moreRead less
Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining ....Optimising seed sourcing for effective ecological restoration. This project aims to address the sourcing of native seed for ecological restoration under global change. The great demand for native seed to deliver ecological restoration provides a clear need and responsibility to use this seed as efficiently as possible. This project expects to develop detailed new knowledge that links plant and environmental genomics, plant physiology, seed and soil biology in embedded experiments at post-mining rehabilitation sites. Expected outcomes include clear industry guidelines that refine seed sourcing strategies for ecological restoration for current and future climates. This should provide significant benefits for improved ecological restoration outcomes when using native seed today and into the future.Read moreRead less
Development of cryopreservation for high value provenance collections of recalcitrant plant species used in post-mining restoration. This project will develop new and innovative ways to store highly valued native plant germplasm at ultra cold temperatures (-196 °C, in liquid nitrogen) as a means to ensure that elite genotypes used in minesite restoration and critically endangered species are not lost forever to extinction. This project will be the first of its type in Australia utilising a multi ....Development of cryopreservation for high value provenance collections of recalcitrant plant species used in post-mining restoration. This project will develop new and innovative ways to store highly valued native plant germplasm at ultra cold temperatures (-196 °C, in liquid nitrogen) as a means to ensure that elite genotypes used in minesite restoration and critically endangered species are not lost forever to extinction. This project will be the first of its type in Australia utilising a multidisciplinary approach to answer key storage questions and will provide significant national benefits to conservation programs and landcare groups, providing these with additional resources to ensure the long-term survival of native plant germplasm collections. Read moreRead less
Mine-site rehabilitation through novel plant and microbe interactions. This project will endeavour to improve restoration technologies aimed at reconstructing diverse and resilient new plant communities following disturbance. The factors which govern successful outcomes of restoration are not fully understood. Current restoration practices rely on the soil microbial community to generate key microbial ecosystem services but their function in novel post-mining substrates modified with soil amelio ....Mine-site rehabilitation through novel plant and microbe interactions. This project will endeavour to improve restoration technologies aimed at reconstructing diverse and resilient new plant communities following disturbance. The factors which govern successful outcomes of restoration are not fully understood. Current restoration practices rely on the soil microbial community to generate key microbial ecosystem services but their function in novel post-mining substrates modified with soil ameliorants is limited. The project aims to use next-generation DNA sequencing to elucidate the structure and function of microbial ecosystem dynamics in modified substrates and apply this understanding to improve restoration outcomes for species and communities affected by the expansion of mining activities in the Pilbara and nationally.Read moreRead less
A Future Beyond the Wall: Improving Post-release Employment Outcomes for People Leaving Prison. Engaging in meaningful work has been shown to reduce re-offending by ex-prisoners, but few prison releasees internationally or in Australia gain employment, and successful pathways to employment for this group are poorly researched and understood. This study aims to gather and analyse, for the first time, comparative data from Australian jurisdictions and employment agencies on the relationship betwee ....A Future Beyond the Wall: Improving Post-release Employment Outcomes for People Leaving Prison. Engaging in meaningful work has been shown to reduce re-offending by ex-prisoners, but few prison releasees internationally or in Australia gain employment, and successful pathways to employment for this group are poorly researched and understood. This study aims to gather and analyse, for the first time, comparative data from Australian jurisdictions and employment agencies on the relationship between in-prison and post-prison vocational education and employment programs, employment and recidivism. It aims to identify effective elements, strategies, program and policy directions in offender training and employment. This is a unique partnership amongst key academics in the field, peak national bodies, correctional and employment organisations.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100034
Funder
Australian Research Council
Funding Amount
$4,986,473.00
Summary
ARC Training Centre for Healing Country. Healing Country aims to be a world-first on-country capability, employment and business development training centre for Indigenous Australians. The centre aims to achieve cost-effective restoration solutions that grow and strengthen Indigenous enterprises, expand and bolster diverse training pathways, and conduct innovative research to support the advancement of a diversified Indigenous-led Restoration Economy. Healing Country will fuse Indigenous culture ....ARC Training Centre for Healing Country. Healing Country aims to be a world-first on-country capability, employment and business development training centre for Indigenous Australians. The centre aims to achieve cost-effective restoration solutions that grow and strengthen Indigenous enterprises, expand and bolster diverse training pathways, and conduct innovative research to support the advancement of a diversified Indigenous-led Restoration Economy. Healing Country will fuse Indigenous culture in a cooperative vision where science and traditional approaches to land management and rehabilitation will create and nourish an economy that supports healthy land and transform Indigenous restoration businesses into a major employer of on-country regional jobs.Read moreRead less
Fire management of complex rehabilitated forests - quantifying and understanding spatial variability of forest structure and fuels. Up to 5 million ha of forest is burnt by bushfire in Australia in severe fire years. The cost of fire suppression in 2002/3 in WA was in excess of 12 million dollars. Consequently, development and application of technologies and knowledge for enhancing fire management and reducing wildfire risk is of high priority and substantial economic, social and environmental b ....Fire management of complex rehabilitated forests - quantifying and understanding spatial variability of forest structure and fuels. Up to 5 million ha of forest is burnt by bushfire in Australia in severe fire years. The cost of fire suppression in 2002/3 in WA was in excess of 12 million dollars. Consequently, development and application of technologies and knowledge for enhancing fire management and reducing wildfire risk is of high priority and substantial economic, social and environmental benefit. The opportunity to conduct experimental fires across a complex landscape will enable calibration and development of technologies not previously possible. This research will define the way prescribed fire is used to integrate young rehabilitated forest into management of the broader landscape and develop more cost-effective tools for fire management.Read moreRead less
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
Robust strategies for restoring aquatic and riparian biodiversity. Effective restoration of Australia's degraded river ecosystems requires a diverse range of spatial data, models and a structured decision-making framework to predict ecological responses to alternative management interventions. This collaboration of universities and National Resource Management agencies will create the necessary tools to make and validate such predictions.