I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.
Atrial fibrillation is the most common heart rhythm disturbance with a prevalence of approximately 1% but which increases markedly with age. It causes debilitating symptoms, heart failure, stroke and increased mortality. It is an important determinant of neuro-cognitive decline and dementia. The studies in this proposal will help define the mechanism of this rhythm disturbance and its associated symptoms. They will help design improved treatment strategies including interventional approaches.
I am a clinician researcher in paediatric emergency medicine. My research focus is acute neurological problems and includes both high volume and rare but life threatening conditions in children. Award of an NHMRC Practitioner Fellowship will allow me to address major evidence gaps in the acute care of children presenting to the emergency department with head injuries and brain attacks (acute neurological dysfunction), and to translate the findings into widespread practice.
Stroke is a devastating disease affecting 50,000 Australians and over 5 million people globally every year. The overall aims are to develop better knowledge, better tools and more effective strategies to treat and prevent stroke. Projects include discovery of new genetic stroke risk factors, better management of recognised risk factors, trials of treatment strategies for acute stroke, and the investigation of strategies for more effective implementation of treatments.
Discovery To Therapy Implementation In Acute Stroke
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
Advances in acute stroke therapies are occurring rapidly but challenges remain in their safe and effective delivery to stroke sufferers. This research focuses on testing a potentially superior ‘clot busting’ drug therapy for acute stroke and on identifying reasons why one of the most widely used current therapies carries a risk of significant harm due to bleeding into the brain. The work also investigates how to better implement the newest form of acute therapy, mechanical blood clot extraction.
Atrial fibrillation (AF) has reached epidemic proportions. It results in significant burden to the individual and community with palpitations, falls, strokes, and heart failure which have contributed to an exponential rise in health care usage and hospitalisation. This application will focus on the optimal management of AF with a focus not only on therapeutics but importantly on the prevention of the arrhythmia and minimising hospitalisation.
An Integrated Research Program In Clincial Toxicology Toxicovigilance And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Drug-related deaths in Australia account for 6.6% of all deaths (ABS 2009). In much of the rural Asia-Pacific, pesticide poisoning and snakebite are major problems. This research supports an integrated national and international clinical toxicology research program covering medicine and chemical poisoning, serious adverse drug reactions, snake and spider bite. Its focus is on the applied research needed to detect new problems and rapidly translate early findings into better treatment, regulation ....Drug-related deaths in Australia account for 6.6% of all deaths (ABS 2009). In much of the rural Asia-Pacific, pesticide poisoning and snakebite are major problems. This research supports an integrated national and international clinical toxicology research program covering medicine and chemical poisoning, serious adverse drug reactions, snake and spider bite. Its focus is on the applied research needed to detect new problems and rapidly translate early findings into better treatment, regulations & policy.Read moreRead less
Generating And Translating Evidence Into Practice In Womens Health And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$501,659.00
Summary
Obesity is increasing with major reproductive and metabolic health impacts for women and the next generation. This fellowships focuses on prevention of obesity and optimal diagnosis and management of obesity related reproductive and metabolic conditions in women including before and during pregnancy. Translation is vital to deliver health benefits from research. Here Prof Teede will generate new evidence and translate this into practice in women’s health and beyond to deliver tangible impact.
Prevention And Improved Management Of Paediatric Food Allergy
Funder
National Health and Medical Research Council
Funding Amount
$479,882.00
Summary
There is an urgent need to prevent food allergy and better manage its consequences. My research will identify: causes of food allergy (primary prevention); factors leading to adverse events in food allergic children (secondary prevention); and the role of food allergy in the ‘atopic march’ i.e. progression to other allergic conditions (tertiary prevention). The results of my research will be used to update policy and practice guidelines to change behaviour and improve clinical care.
Improving Clinical Understanding And Management Of Tendinopathy
Funder
National Health and Medical Research Council
Funding Amount
$487,621.00
Summary
Painful tendons occur in people of all ages. Treatment outcomes are variable and many people are left with chronic pain and limited capacity to be active. This research will investigate the development of tendinopathy, the cause of tendon pain and examine imaging methods to improve management. This research expects to demonstrate that tendon injury develops during puberty, that the brain has a central role in tendon pain, and that regular monitoring of tendon structure can improve outcomes.