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Stroke is a major cause of death and disability in adult across the world. Understanding how exactly brain cells are affected in stroke and how they are injured, and how they response to treatment is important in order to develop new treatment to maximize recovery and minimize brain injury after stroke. This project uses advanced MRI being performed at several time points after a stroke to study how the brain tissues recovers or dies after a stroke.
Mapping The 3-dimensional Structure Of The Human Atria
Funder
National Health and Medical Research Council
Funding Amount
$61,192.00
Summary
Our project aims to shed the light on the mechanism of atrial fibrillation (AF). AF is the most common sustained heart rhythm abnormality and contributes to a significant socioeconomical burden on the healthcare system. We plan to use mapping catheters to record and analyse electrical signals from the small chambers of the heart in patients with atrial fibrillation. The results will contribute to improvements in our current approach in AF ablation to cure this disabling arrhythmia.
Establishing A Model Of Occlusive Middle Cerebral Artery Stroke In The Sheep
Funder
National Health and Medical Research Council
Funding Amount
$74,365.00
Summary
Stroke is the second leading cause of death and the highest cause of disability in adult Australians, however our lack of an animal model that correctly replicates the human condition has severely hindered our understanding and treatment of the disease. This research project aims to develop a model of stroke in the sheep using a surgical approach that future researchers may use and adapt to further explore the physiology of the disease and trial therapeutic techniques to treat stroke.
The majority of stroke results from focal brain infarction, followed by substantial secondary excitotoxic damage in the surrounding areas. Tau has been shown to contribute to excitotoxicity and neurodegeneration in mouse models of Alzheimer’s disease (AD). Preliminary data show that tau reduction also protects against excitotoxic damage after experimental stroke. We aim to dissect the molecular mechanisms of stroke using a tau-deficient mouse model.
Using Diffusion MRI For Understanding The Relationship Between Memory Decline And Corticothalamic Tracts
Funder
National Health and Medical Research Council
Funding Amount
$57,578.00
Summary
Stroke populations are at a risk of dementia. Structural changes have been demonstrated to precede cognitive changes, providing a potential for early diagnosis and intervention. Magnetic resonance imaging markers of structural connectivity are powerful predictors of dementia. As a longitudinal study, this proposal has the unique advantage that I will be able to detect changes in post-stroke brain networks in the 3 years after stroke. This raises the potential for future clinical application.
This project will investigate the link between vitamin D and falls in people with stroke. It will be the first study to examine associations between vitamin D and falls in people with stroke and establish whether interventions to prevent falls in people with stroke may need to include vitamin D supplementation. This project is a first vital step towards developing an effective falls prevention intervention for the large numbers of Australian stroke survivors, which currently does not exist.