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Understanding The Cause Of Muscle Weakness In Nemaline Myopathy (NM) – Moving Towards The Development Of Targeted Treatments
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Congenital myopathy patients have unremitting, life-long muscle weakness that severely affects their quality of life and ability to perform normal daily activities. Currently no effective therapies exist for these conditions, largely due to our limited understanding of the mechanisms leading to muscle weakness. This ECF aims to determine the cause of weakness and test two therapies which have shown promise for other conditions and can be translated into clinical use for myopathies if effective.
Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Dissecting The Molecular Mechanisms Behind Actin Filament Disassembly - An Essential Process In Malaria Parasite Cell Movement
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
The malaria parasite’s survival is reliant on efficient cell movement - a process that depends on the remodeling of the parasite actin cytoskeleton. The aim of this project is to understand how the actin cytoskeleton is disassembled when the parasite moves and to dissect the role of a key parasite protein, PfADF1, in the process. This project will elucidate fundamental insights into a key aspect of malaria parasite biology and, significantly, will shed light on how parasite movement can be inhib ....The malaria parasite’s survival is reliant on efficient cell movement - a process that depends on the remodeling of the parasite actin cytoskeleton. The aim of this project is to understand how the actin cytoskeleton is disassembled when the parasite moves and to dissect the role of a key parasite protein, PfADF1, in the process. This project will elucidate fundamental insights into a key aspect of malaria parasite biology and, significantly, will shed light on how parasite movement can be inhibited.Read moreRead less