Posttraumatic Mental Health: Advancing Understanding Of Diagnosis, Treatment And Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$7,590,920.00
Summary
Psychological disorders following exposure to trauma account for a significant proportion of the burden of disease in terms of personal suffering, decreased productivity, occupational dysfunction, and demands on health services. This project will enhance the nation's capacity to reduce psychological problems after trauma. This project will consolidate a critical mass of Australia's leading trauma researchers that will ensure that Australia retains its leading edge in posttraumatic research.
Posttraumatic Mental Health: Enhancing Resilience And Recovery
Funder
National Health and Medical Research Council
Funding Amount
$5,043,011.00
Summary
Psychological disorders following exposure to trauma account for a significant proportion of the burden of disease in terms of personal suffering, decreased productivity, occupational and social dysfunction, medical disorders, and demands on health services. The overall goal of this project is to enhance the nation’s capacity in research into the identification of risk factors for posttraumatic mental disorders, study of neurophysiological factors mediating these disorders, and evaluation of tre ....Psychological disorders following exposure to trauma account for a significant proportion of the burden of disease in terms of personal suffering, decreased productivity, occupational and social dysfunction, medical disorders, and demands on health services. The overall goal of this project is to enhance the nation’s capacity in research into the identification of risk factors for posttraumatic mental disorders, study of neurophysiological factors mediating these disorders, and evaluation of treatment strategies to reduce psychological morbidity after trauma. This project will develop a critical mass of Australia’s leading trauma researchers that will ensure that Australia retains its leading edge in posttraumatic research.Read moreRead less
Atherosclerosis:Lipoproteins, Cell Biology And Vascular Physiology
Funder
National Health and Medical Research Council
Funding Amount
$7,274,391.00
Summary
The team comprises internationally recognised experts in basic, clinical and public health applied research in cardiovascular disease, particularly atherosclerosis that is the commonest cause of death in Australia and other developed countries. Over the last decade, improvement in cardiovascular health has been primarily the result of a better understanding on how to control 'bad' (or LDL) cholesterol. The significance of the proposed studies is that, on the one hand, they will provide new infor ....The team comprises internationally recognised experts in basic, clinical and public health applied research in cardiovascular disease, particularly atherosclerosis that is the commonest cause of death in Australia and other developed countries. Over the last decade, improvement in cardiovascular health has been primarily the result of a better understanding on how to control 'bad' (or LDL) cholesterol. The significance of the proposed studies is that, on the one hand, they will provide new information on how 'good' lipoproteins protect us from atherosclerosis. This information can then be used to regulate 'good' cholesterol in a meaningful manner. On the other hand, the proposed studies will provide fundamental insights into how a range of lifestyle factors, physiological processes and pathological conditions relate to both the function of blood vessel-lining cells and susceptibility of individuals to atherosclerosis.Read moreRead less
MOLECULAR AND CELLULAR PATHOGENESIS OF HUMAN LIVER DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$4,928,323.00
Summary
n humans, chronic liver diseases cause cirrhosis of the liver in some but not all individuals. This leads to protracted ill-health, complications (fluid retention in the abdomen, confusion, bloodstream infections, kidney failure, liver cancer) resulting in hospitalisation, liver transplantation and premature death. In Australia, cirrhosis is an important cause of death and of years of potential life lost, while liver cancer has recently doubled and is predicted to treble by 2020. The common caus ....n humans, chronic liver diseases cause cirrhosis of the liver in some but not all individuals. This leads to protracted ill-health, complications (fluid retention in the abdomen, confusion, bloodstream infections, kidney failure, liver cancer) resulting in hospitalisation, liver transplantation and premature death. In Australia, cirrhosis is an important cause of death and of years of potential life lost, while liver cancer has recently doubled and is predicted to treble by 2020. The common causes are hepatitis C, fatty liver disorders, alcohol and hepatitis B; when 2 of these are present together, there is a higher risk of cirrhosis. This program aims to unravel the pathological processes which cause cirrhosis at the molecular and cellular levels, in order to understand why some people are at higher risk. These processes could result from genetic predisposition, other constitutional factors (age, gender) or from lifestyle factors (overnutrition, inactivity, alcohol). The 3 chief investigators from Westmead s Millennium Institute and the Centenary Institute of Royal Prince Alfred Hospital are international experts in hepatitis C, non-alcoholic steatohepatitis (NASH) and other fatty liver disorders, autoimmune hepatitis, liver transplantation, and scarring processes that lead to cirrhosis of the liver. The new knowledge that will result from these studies will be used to help prevent people developing severe forms of chronic liver disease, and for treating cirrhosis if it has already occurred.Read moreRead less