Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
Neuromuscular adaptations to training, cross training and passive physical interventions: A neurophysiological approach to understanding human performance and musculoskeletal injury. The expected national benefit arising from this research is three fold: (i) developing knowledge of approaches taken to improve exercise performance across the spectrum of novice to elite levels of participation, (ii) improved understanding of the physiological basis for widely applied interventions used to facilita ....Neuromuscular adaptations to training, cross training and passive physical interventions: A neurophysiological approach to understanding human performance and musculoskeletal injury. The expected national benefit arising from this research is three fold: (i) developing knowledge of approaches taken to improve exercise performance across the spectrum of novice to elite levels of participation, (ii) improved understanding of the physiological basis for widely applied interventions used to facilitate exercise, performance, as well as injury prevention and rehabilitation, and (iii) increasing the pool of world-class researchers who will make a substantial difference to the health and wellbeing of the community through one post-doctoral and two doctoral programs. This project will cement existing tertiary-industry sector collaboration, which will ensure long-standing benefits to the community.Read moreRead less
Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also ....Co-design and dynamic mission optimisation of hypersonic flight vehicles. This project aims to deliver fundamental knowledge by integrating the modelling and control with the design of next generation hypersonic platforms. In an era where Australia's national security reliance on geographic isolation and support from allied forces are being challenged, the research outcomes of this project will play an important role in understanding the capabilities of hypersonic systems. The project will also have significant spillover benefits into other complex system domains, where computational tools can be used to aid in design leading to high embedded-IP products for Australian industry. Furthermore, the proposal encompasses a strong research training aspect, with graduates exposed to leading edge industry and academia.Read moreRead less
Competing demands on the axial muscles: Effects, consequences, compensations and mechanisms. Back and neck pain are major health issues and are associated with considerable cost to society and an individual's quality of life. A major issue is to identify factors that increase the chance of developing pain. This project will investigate a novel and innovative possibility; that competition between the many functions of the trunk muscles may increase the possibility for injury. We will study how th ....Competing demands on the axial muscles: Effects, consequences, compensations and mechanisms. Back and neck pain are major health issues and are associated with considerable cost to society and an individual's quality of life. A major issue is to identify factors that increase the chance of developing pain. This project will investigate a novel and innovative possibility; that competition between the many functions of the trunk muscles may increase the possibility for injury. We will study how the nervous system coordinates functions as diverse and movement of the spine, breathing, and control of head and eye movement. A key issue will be to identify whether situations arise in which control of the spine is compromised, potentially leading to increased risk of pain and injury. Such data can aid prevention and rehabilitation.Read moreRead less
Investigating the Effects of Network-Induced Delays on Networked Control Systems. Networked control is the current trend for industrial automation. The results of this project will be the first in the world to contribute directly to a deeper understanding of both negative and positive effects of network-induced delays on networked control systems. It will firmly place Australia at the forefront of this research by developing cutting edge technology for reliability and efficiency of industrial ne ....Investigating the Effects of Network-Induced Delays on Networked Control Systems. Networked control is the current trend for industrial automation. The results of this project will be the first in the world to contribute directly to a deeper understanding of both negative and positive effects of network-induced delays on networked control systems. It will firmly place Australia at the forefront of this research by developing cutting edge technology for reliability and efficiency of industrial networked-based control systems. This novel frontier technology will result in cost-saving and improved productivity for Australian industries, e.g. manufacturing industries, power stations, processing industries, automotive industries, vehicular networks and locomotives.Read moreRead less
Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency ....Variable Structure Control Systems in Networked Environments. This project will be the first in the world to lay the foundation for a new theory for understanding and designing new variable structure control systems in the networked environments, which is in great need due to increasing use of shared communication networks in modern industrial systems. It will firmly place Australia at the forefront of this research by developing a cutting edge technology for improving reliability and efficiency of industrial variable structure control systems in the networked environments, hence resulting in cost-saving and improved productivity for industry. It will provide training for new leading researchers specialised in this new theory and technology.Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Identifying Resistance Mechanisms Of Targeted BRAF Inhibitors In Metastatic Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$379,015.00
Summary
Late-stage melanoma is an aggressive skin cancer for which traditional treatment strategies such as chemotherapy are ineffective. Recently, a new class of targeted drugs (BRAF inhibitors) has become the standard of care for a subset of melanoma patients; however, long term treatment success is complicated by drug resistance. This study will identify the causes of resistance with the purpose to improve targeted drug strategies and increase survival rates for late-stage melanoma patients.
Discovery Early Career Researcher Award - Grant ID: DE210101864
Funder
Australian Research Council
Funding Amount
$442,500.00
Summary
Unlocking Urban Airspace for Drone Transport. This project aims to accurately quantify the mid-air collision risk associated with low-altitude unmanned operations in urban airspace through the creation of new data-driven collision risk modelling techniques. Without such techniques, drone operations remain suppressed so their true potential cannot be realised. The collision risk models address this by providing the key missing knowledge that can underpin/enable vital unmanned traffic management ....Unlocking Urban Airspace for Drone Transport. This project aims to accurately quantify the mid-air collision risk associated with low-altitude unmanned operations in urban airspace through the creation of new data-driven collision risk modelling techniques. Without such techniques, drone operations remain suppressed so their true potential cannot be realised. The collision risk models address this by providing the key missing knowledge that can underpin/enable vital unmanned traffic management applications, including airspace design and the development of separation standards. This can ultimately enable greater access to urban airspace without compromising air safety such that we unlock the commercial and societal benefits of drone use and help modernise urban air transportation.
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Automated vision-based aircraft collision warning technologies. Australia is a sparsely populated country with a number of unique airspace features. This project will investigate novel vision-based collision warning systems that can improve safety for piloted aircraft and also help achieve integration of UASs (Uninhabited Aerial Systems) into national airspace. The benefits of UAS technologies are particularly relevant to Australia, as governments and industry struggle to cope with providing equ ....Automated vision-based aircraft collision warning technologies. Australia is a sparsely populated country with a number of unique airspace features. This project will investigate novel vision-based collision warning systems that can improve safety for piloted aircraft and also help achieve integration of UASs (Uninhabited Aerial Systems) into national airspace. The benefits of UAS technologies are particularly relevant to Australia, as governments and industry struggle to cope with providing equivalent levels of service to remote communities over vast distances (or border protection of vast regions). The population base of Australia requires that cost-effective solutions are sought to meet this end. Read moreRead less