Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Waxing And Waning Of Asthma During Transition From The Teens To Adulthood: Identification Of Immunophenotypic Markers To Predict Disease Trajectory And Guide Development Of Treatment Strategies To Prevent Progression To Chronicity
Funder
National Health and Medical Research Council
Funding Amount
$736,166.00
Summary
The project will seek to identify biomarkers in teenage/young adult asthmatics that can distinguish between those who are "growing out" of the disease, versus those who are progressing towards chronic severe asthma. This knowledge will inform the development of more effective treatment programs for this age group.
Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Eliminating Hepatitis C Transmission By Enhancing Hepatitis C Care And Treatment In Primary Health Care Settings.
Funder
National Health and Medical Research Council
Funding Amount
$1,221,831.00
Summary
In developed countries, people who inject drugs (PWID) are the group at greatest risk of hepatitis C (HCV) infection but few PWID receive HCV treatment. With the advent of highly effective non-interferon based treatments HCV elimination, although ambitious, is now being seriously considered globally. This partnership grant will explore the feasibility of eliminating HCV transmission by enhancing HCV care and treatment for PWID in primary health care settings.
Remediation of Underground Contaminant Source Areas using Nano-scale, Zero Valent Iron and Potassium Permanganate. Land in parts of Australia valued in the hundreds of millions of dollars is currently contaminated by organic compounds to levels unsuitable for human health and safety . At many of these contaminated sites, the contamination is present as pure, separate phase oil that is trapped due to geology or other physical reasons. This remaining oil is a long term source of contamination, a ....Remediation of Underground Contaminant Source Areas using Nano-scale, Zero Valent Iron and Potassium Permanganate. Land in parts of Australia valued in the hundreds of millions of dollars is currently contaminated by organic compounds to levels unsuitable for human health and safety . At many of these contaminated sites, the contamination is present as pure, separate phase oil that is trapped due to geology or other physical reasons. This remaining oil is a long term source of contamination, and is exceptionally difficult to remediate. The proposed research will investigate a novel and highly effective approach to destroying this contamination in the ground, helping to restore the value and utility of the land.Read moreRead less
Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
Green catalysis for energy and environment using metal free nanostructured carbons. This project will advance the nanomaterial design and science underpinning the development of green technologies for important chemical production and water treatment. The outcomes of this project will help Australia in a leading position in the sustainable development of nanotechnology and water remediation.
Vegetable Oils as Dielectric Liquid for Oil Filled Distribution and Power Transformers. A new transformer cooling and insulating liquid is proposed from vegetable oil seeds available in Australia. The proposed liquid will be fully biodegradable and non-toxic and will cause no harm in the event of explosions or accidental leakage from a transformer. Approximately, 30 to 40 billion liters of oils are in use in transformers worldwide. The development of this liquid requires selection of suitable ve ....Vegetable Oils as Dielectric Liquid for Oil Filled Distribution and Power Transformers. A new transformer cooling and insulating liquid is proposed from vegetable oil seeds available in Australia. The proposed liquid will be fully biodegradable and non-toxic and will cause no harm in the event of explosions or accidental leakage from a transformer. Approximately, 30 to 40 billion liters of oils are in use in transformers worldwide. The development of this liquid requires selection of suitable vegetable oil base;thermal and oxidation stabilization; electrical performance,biodegradability,and endurance testings, viscosity and pour point improvements, compatibility tests with existing oils, and characterization of its gassing phenomena. The development of this new liquid from local oil seeds will provide the Australian industry huge export potentials. The prject will also provide Australian farmers a new avenue for their oilseed market.Read moreRead less
The Influence of Fracture Network Topology on Fluid Flow in the Subsurface. This project focuses on developing methods for the simulation of fluid flow in fractured rock aquifers. Given the large computational requirements involved in modelling discretely fractured rock masses, scaling approaches are required to allow for simulation at field scales. The sensitivity of the scaling to the parameters describing the fracture network will be investigated. It is anticipated that the scaled function ....The Influence of Fracture Network Topology on Fluid Flow in the Subsurface. This project focuses on developing methods for the simulation of fluid flow in fractured rock aquifers. Given the large computational requirements involved in modelling discretely fractured rock masses, scaling approaches are required to allow for simulation at field scales. The sensitivity of the scaling to the parameters describing the fracture network will be investigated. It is anticipated that the scaled functional relationships will be quite network specific, and that the identification of the controls on the form of the scaling relationships will allow for the focussing of data acquisition to the most salient information, and will reduce the costs involved.Read moreRead less