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Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
A Randomised Controlled Trial Of Alternative Treatments To Intramuscular Penicillin For Impetigo In Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$1,326,182.00
Summary
We will conduct clinical trials to find an effective, simple and cheap oral alternative to injected penicillin for skin sores which could become the universal standard of care whether the patient is in Melbourne or Milingimbi. It would also likely be adopted by the World Health Organization as a standard of care for developing countries. This would lead directly to a reduced burden of skin sores and their complications. It would also open the way for studies to explore even simpler regimens.
Linking Genomics Of Burkholderia Pseudomallei To Melioidosis: Diversity Of Clinical Manifestations, Changing Epidemiology And Microevolution In Chronic Carriage.
Funder
National Health and Medical Research Council
Funding Amount
$602,769.00
Summary
The Darwin Prospective Melioidosis Study has documented 761 cases since 1989, with 102 fatalities. This study has led to improved therapy and public health initiatives. New technology to sequence whole bacterial genomes provides an opportunity to determine why urban melioidosis is increasing and to analyse this unique 22+ year set of bacteria and their linked patient data to find the important bacterial virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a ....Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a parent-implemented early childhood language program designed to buffer against effects of childhood otitis media can support indigenous children in remote northern Australia. Outcomes aim to be data on effects on children's language, attention, and school readiness, plus uptake of strategies and knowledge by parents and other adults, and evidence regarding best practice in such contexts.Read moreRead less