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The Cellular Origin And Nuclear Signaling Mechanisms Of Cardiac Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$383,893.00
Summary
Stem cells have special characteristics; they are able to be grown quickly and they have the potential to turn into different types of cell. These two characteristics indicate the potential to use these cells to repair diseased organs. Heart disease is an ideal area to investigate the use of such cell-based therapy options. This is because a weakened heart muscle is very common (especially as we age) and because without assistance, the body is not able to repair a weakened heart.
Customized IPS Cell Therapy For Recessive Monogenic Retinal Degenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$350,714.00
Summary
The focus of this study is to develop a personalised treatment for certain types of retinal degenerative disease (RDD). Stem cells will be generated from the skin cells obtained from an individual with RDD. Gene therapy will then be applied to correct the underlying disease-causing mutation in the patient cells. The repaired cells will be used to generate retinal cells, which will subsequently be tested in naturally occurring RDD rodent models to determine if they have any beneficial effects.
Identification Of Cancer Initiating Cells In Small-cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$364,420.00
Summary
Lung cancer is the leading cause of cancer deaths worldwide. Recently a unique mouse model of small-cell lung cancer (SCLC) has been generated that closely mimics the human disease. We will use this model to identify the cells that give rise to SCLC upon genetic alteration. Results obtained will assist in designing more effective intervention strategies aimed at overcoming initial and acquired resistance of these tumours against cytotoxic and targeted drugs.
Identifying Genes That Function As Epigenetic Barriers To Cell Reprogramming
Funder
National Health and Medical Research Council
Funding Amount
$379,649.00
Summary
Stem cells can form many different cell types and show significant promise in cell therapies. New technologies allow the generation of stem cells from adult cell types such as skin cells, but these technologies are inefficient and typically introduce new genetic material to the cells. This project will develop new, more efficient approaches for producing stem cells potentially without the introduction of genetic material, thereby improving the use of these stem cells in therapies.
Reprogramming is the conversion of any cell into induced pluripotent stem cells (iPSC). iPSC carry immense clinical potential as they are pluripotent and can hence form any cell of the human body, however, they can also form tumours. We have identified a cell type during reprogramming which is pluripotent but cannot form tumours. It is the aim of this project to determine the molecular differences between iPSC and this cell type in order to facilitate the delivery of cell replacement therapies.
Cell Therapy To Prevent And Treat Graft-versus-host Disease After Allogeneic Haematopoietic Stem Cell Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$260,302.00
Summary
In bone marrow transplantation, donor immunity can fight the cancer but can also attack healthy tissues, causing graft-versus-host disease (GVHD). We will use two types of cell therapy to treat GVHD. The first study will use a safety switch called inducible capase 9 (iCasp9) to enable the donor immune cells to be rapidly eliminated if GVHD occurs. The second study will use regulatory T cells to treat patients with chronic GVHD. If successful, these treatment approaches will make transplantation ....In bone marrow transplantation, donor immunity can fight the cancer but can also attack healthy tissues, causing graft-versus-host disease (GVHD). We will use two types of cell therapy to treat GVHD. The first study will use a safety switch called inducible capase 9 (iCasp9) to enable the donor immune cells to be rapidly eliminated if GVHD occurs. The second study will use regulatory T cells to treat patients with chronic GVHD. If successful, these treatment approaches will make transplantation safer.Read moreRead less
Transcription factors (TFs) read cis-regulatory information encoded in the genome. However, they must compete with structural chromatin proteins such as nucleosomes for access to DNA motifs. It is unclear what features discriminate used from unused binding sites with similar motifs, in vivo. To provide insight and general principles of TF biology, I will express variants of a model TF in mammalian cells and test the contribution that specific molecular properties have on genomic binding.
Developing A Pathophysiological Model For Attention Deficit Hyperactivity Disorder: A Path To Biomarker Discovery
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Despite the efficacy of stimulant medication in treating attention deficit hyperactivity disorder (ADHD), we lack mechanistic accounts of the neuropathology of ADHD. A major barrier is the lack of human disease models representing clinical symptoms. The derivation of a novel, cell-based ADHD model proposed in this project will shed new light on the physiological bases of ADHD and be a rich resource for biomarker discovery
Adult and embryonic stem cells have enormous therapeutic potential. Haemopoietic stem cells have been the most intensely studied and widely used in a therapeutic setting, yet we have only a patchy knowledge of the genes required for their proliferation and survival. I will use classical genetic screens in the mouse to identify genes that regulate stem cell behaviour. I will analyse two existing mutant mouse strains with reduced numbers of haemopoietic stem cells, and execute a novel genetic scre ....Adult and embryonic stem cells have enormous therapeutic potential. Haemopoietic stem cells have been the most intensely studied and widely used in a therapeutic setting, yet we have only a patchy knowledge of the genes required for their proliferation and survival. I will use classical genetic screens in the mouse to identify genes that regulate stem cell behaviour. I will analyse two existing mutant mouse strains with reduced numbers of haemopoietic stem cells, and execute a novel genetic screen utilising mice with a defect in the self-renewal of adult haemopoietic and neural stem cells, to find mice with a recovered stem cell compartment.Read moreRead less