Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell typ ....Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell types will provide biological scientists with more realistic in-vitro cell assays to those found in-vivo. Applications of the research are in cell biology, studying diseases and developing new drugs.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100003
Funder
Australian Research Council
Funding Amount
$1,814,346.00
Summary
New directions, new problems and new data types in statistical science. Statistically challenging problems today involve answering many more questions than we have data. Solving them will elucidate the causes of diseases such as cancer, and provide better security for the community. The project will develop new methods for tackling these challenging problems, taking statistical science in new directions.
Detection of infrared-biomarkers for the diagnosis and treatment of canine neoplasia. This research hopes to discover infrared-biomarkers for canine cancers using synchrotron infrared and laser light. Many dog cancers are similar to human cancers so cancerous tissues and cells from dogs make excellent models for human cancer research. This project will provide new insights and technological approaches to cancer diagnosis and treatment.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Nonparametric data analysis in statistical science. Changes in technology have enabled new types of data to be collected, often more complex and in much larger quantities than ever before, and altered fundamentally the types of questions that need to be asked of those data. The research program will develop new statistical methods for analysing new types of data, for example functional data and data with many dimensions, and will also introduce greatly improved solutions to problems that involve ....Nonparametric data analysis in statistical science. Changes in technology have enabled new types of data to be collected, often more complex and in much larger quantities than ever before, and altered fundamentally the types of questions that need to be asked of those data. The research program will develop new statistical methods for analysing new types of data, for example functional data and data with many dimensions, and will also introduce greatly improved solutions to problems that involve more conventional data types. These techniques will have critical applications to diverse fields. The program will contribute substantially to capacity building in a strategically important area, statistical science, of great value to Australia but where chronic skills shortages exist.Read moreRead less
Rapid detection of rare-event cells by strong UP-conversion
encoded nano-radiators (SUPER Dots): finding a needle in a haystack. Current diagnostic tests are not sensitive enough to detect cancer in its very early stages or early recurrence following treatment. The new technologies developed by this project will be able to find single cancer cells in blood and urine samples heralding a new era in medical diagnostics.
Discovery Early Career Researcher Award - Grant ID: DE150101655
Funder
Australian Research Council
Funding Amount
$297,036.00
Summary
Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretatio ....Discriminative detection and quantification of cancer imaging biomarkers. This project aims to develop a new framework for the detection and quantification of cancer biomarkers in diagnostic and histopathology images with discriminative modelling of intrinsic structures. The framework will be the first computerised solution to provide automated, quantitative annotations of cancer imaging biomarkers at the macroscopic and microscopic levels to support standardised reporting of image interpretation. It will help to alleviate the inter-observer variability and time-consuming process of manual analysis. The project aims to advance fundamental biomedical imaging research in generalised visual structure extraction and classification, and enable large-scale translational research in systems pathology for personalised cancer care.Read moreRead less
Image-guided skin microbiopsy technology development. There is a need for targeted biopsies in dermatology. This novel technology enables minimally invasive biopsies to be taken from suspicious skin lesions by integrating micromedical and imaging devices.
The development of tuneable materials to allow the three-dimensional printing of cells. New low cost three-dimensional (3D) printers and reagents will be developed during this project to allow cancer biologists to print cells and polymers as more realistic 3D tissue models for biological assays. Such technology will be important for performing basic research into cancers as well as for providing better tools for drug testing.
Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less