A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of dri ....Thermodynamics inversion for mineral systems. This project aims to provide a newly developed science approach to the Australian Lithospheric Architecture Magnetotelluric Project (AusLAMP). AusLAMP provides unparalleled geophysical information aimed at unravelling the tectonic history of the Australian continent and its mineral potential. The project will use thermodynamically based geodynamic simulators to jointly analyse and quantify intraplate deformation. This will illuminate the cause of driving fluid flow thorough the lithosphere, mineralisation phenomena, their datasets and geometries, and dynamic aspects of the processes driving mineral systems.Read moreRead less
Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radi ....Pharmacological probes to facilitate preclinical development of modulators of a6 subunit containing nicotinic acetylcholine receptors. Allosteric modulators of alpha7 nicotinic acetylcholine receptors have a promising future as drugs targeting attention deficits in Alzheimer’s disease and schizophrenia but the mechanisms underlying modulation are poorly understood. This project aims to determine its binding site and develop a radioactive labelled compound that competes with its binding. The radiolabelled compound and a deeper insight into the mode of action will enable development of ligands for positron emission tomography (PET) which will aid in the development of BNC375 as well as other alpha7 modulators.Read moreRead less
Residents’ voices: advantage, disadvantage, community and place. Community renewal and redevelopment of concentrated public housing areas represents a significant public investment aimed at improving the life chances of residents, yet the way in which place factors influence social outcomes is not well understood. This research will enhance the potential for successful outcomes by creating opportunities for residents to develop and express their own knowledge and understanding of the links betwe ....Residents’ voices: advantage, disadvantage, community and place. Community renewal and redevelopment of concentrated public housing areas represents a significant public investment aimed at improving the life chances of residents, yet the way in which place factors influence social outcomes is not well understood. This research will enhance the potential for successful outcomes by creating opportunities for residents to develop and express their own knowledge and understanding of the links between place and disadvantage, in an international context. The emergence of a theorised, contextualised and well articulated set of explanations about poverty and place from the tenant perspective will also improve public understanding and reduce the social division and stigma currently associated with public housing.Read moreRead less
Borderline Personality as Social Phenomena. Mental disorders attract social stigma and those diagnosed are widely misunderstood. This project aims to collect and analyse accounts of people living with Borderline Personality Disorder (BPD) - mainly women - and perspectives of social support practitioners. The intended outcome is to provide a sophisticated understanding of BPD as a social phenomenon, develop sociological evidence based on lived experiences and generate Australian digital resources ....Borderline Personality as Social Phenomena. Mental disorders attract social stigma and those diagnosed are widely misunderstood. This project aims to collect and analyse accounts of people living with Borderline Personality Disorder (BPD) - mainly women - and perspectives of social support practitioners. The intended outcome is to provide a sophisticated understanding of BPD as a social phenomenon, develop sociological evidence based on lived experiences and generate Australian digital resources including narratives of BPD, creative outputs and practitioner perspectives. The anticipated goal of this project is to inform policy and community responses addressing stigma and marginalisation, and the improvement of social support for those affected by BPD.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
Geomagnetic induced currents in the Australian electricity supply network. This project will develop measures to protect the Australian electricity supply network from adverse effects of enhanced solar activity. This is essential for risk assessment and long term asset management of the Australian electricity network.
Information Seeking & Research Adoption: Assessing Communication Strategies. This project aims to determine the best ways to communicate wine research and to design tools to support research adoption. Adoption of research relies on effective use of information and technology by employees. Research into employees’ information practices in the workplace has been conducted in health care, education and other areas; however, the wine industry’s use of information and technology for adoption is unexp ....Information Seeking & Research Adoption: Assessing Communication Strategies. This project aims to determine the best ways to communicate wine research and to design tools to support research adoption. Adoption of research relies on effective use of information and technology by employees. Research into employees’ information practices in the workplace has been conducted in health care, education and other areas; however, the wine industry’s use of information and technology for adoption is unexplored. The project plans to assess the strategies used to share research with winemakers and grape growers (e.g. seminars, websites, social media), from information behaviour or web useability perspectives, to ensure industry needs are met appropriately. This research aims to have a direct and immediate impact on the wine industry. In addition to the immediate impact of new research innovations that will be implemented by our partner wine companies, the project will also change industry-wide approaches to extension. The partner organisations use extension strategies to showcase new innovations and our research will assess these organisations’ current practices, providing evidence to shape the design of future activities in Australia.Read moreRead less
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Novel technology for enhanced coal seam gas production utilising mechanisms of stimulated cleat permeability through graded particle injection. This cross-disciplinary project will develop a new integrated technology for well productivity enhancement in coal seam gas, shale, tight gas and geothermal reservoirs - the world’s fastest growing unconventional clean energy resources. It will improve our understanding of the multi scale physics of natural gas and energy production.