Alternative Splicing- A Regulatory Mechanism Determining Self-renewal And Pluripotency Of ES And IPS Cells
Funder
National Health and Medical Research Council
Funding Amount
$664,650.00
Summary
Stem cells hold great promise in cell replacement therapies and may provide models to study human diseases and to screen new pharmaceuticals. For successful future therapeutic applications, a deeper understanding of the molecular mechanisms governing the behavior of stem cells is crucial. In this proposal we will investigate the role of alternative splicing in the control of the fundamental properties of stem cells, and identify target RNAs and gene expression networks regulated by splicing fact ....Stem cells hold great promise in cell replacement therapies and may provide models to study human diseases and to screen new pharmaceuticals. For successful future therapeutic applications, a deeper understanding of the molecular mechanisms governing the behavior of stem cells is crucial. In this proposal we will investigate the role of alternative splicing in the control of the fundamental properties of stem cells, and identify target RNAs and gene expression networks regulated by splicing factors.Read moreRead less
Australian Drosophila Biomedical Research Support Facility
Funder
National Health and Medical Research Council
Funding Amount
$1,008,895.00
Summary
Breakthroughs in biomedical research frequently come from the study of model organisms, one of the most important of which is the vinegar fly, Drosophila melanogaster. In Australia, Drosophila is used in biomedical research with a particular focus on understanding processes that result in human cancer or are associated with birth defects or inherited diseases. Drosophila-based research is funded by bodies such as the Anti-Cancer Foundation, the National Health and Medical Research Council (NH an ....Breakthroughs in biomedical research frequently come from the study of model organisms, one of the most important of which is the vinegar fly, Drosophila melanogaster. In Australia, Drosophila is used in biomedical research with a particular focus on understanding processes that result in human cancer or are associated with birth defects or inherited diseases. Drosophila-based research is funded by bodies such as the Anti-Cancer Foundation, the National Health and Medical Research Council (NH and MRC) and the National Institutes of Health of the USA. This proposal seeks to establish infrastructure support for Drosophila research in the form of a central collection of key research stocks, a centralized facility for the importation of genetically defined stocks and a facility for the generation of transgenic Drosophila for use in biomedical research.Read moreRead less