In the normal process of hearing, the brain actively selects sounds of interest from competing background sounds. This normal auditory function is indispensible for children and adults to cope in non-optimal listening environments, however the mechanisms by which such performance is achieved are poorly understood. This project will investigate the nerve circuits that enable this to occur and will also investigate how these circuits malfunction in various types of partial deafness. The results wi ....In the normal process of hearing, the brain actively selects sounds of interest from competing background sounds. This normal auditory function is indispensible for children and adults to cope in non-optimal listening environments, however the mechanisms by which such performance is achieved are poorly understood. This project will investigate the nerve circuits that enable this to occur and will also investigate how these circuits malfunction in various types of partial deafness. The results will improve our understanding of how we detect sounds and the impact of hearing pathologies on this process.Read moreRead less
Auditory Processing Deficits In Specific Language Impairment And Specific Reading Disability:Their Effects And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$314,250.00
Summary
One possible cause of specific language impairment (SLI) and specific reading disability (SRD; commonly known as dyslexia) is an inability to discriminate between sounds. Such an impairment could affect the ability to discriminate between simple speech sounds (phonemes) which are the basic building blocks for developing spoken language and reading skills. How many children with SLI or SRD have poor sound discrimination? What pattern of spoken language and reading impairments do these children ha ....One possible cause of specific language impairment (SLI) and specific reading disability (SRD; commonly known as dyslexia) is an inability to discriminate between sounds. Such an impairment could affect the ability to discriminate between simple speech sounds (phonemes) which are the basic building blocks for developing spoken language and reading skills. How many children with SLI or SRD have poor sound discrimination? What pattern of spoken language and reading impairments do these children have as a result of this impairment? Can poor sound discrimination be fixed? If it can, does it improve spoken language and reading impairments? And if it does, does it have an immediate effect or does it take some time to make a difference? These are some of the questions that will be addressed by this research. The answers will help us develop a training program that focuses specifically on improving the sound discrimination abilities of children who really need it. This will be a more efficient and inexpensive (if not free) than the Fast ForWord program that trains multiple non-verbal and verbal processing abilities regardless of whether a child has an impairment in all (or any) of these abilities and is therefore time consuming (approximately 80 hours) and expensive (approximately $AUD2000). The data will also help up better identify the spoken and written language profiles that characterise children who have sound discrimination deficits so we can better predict whether they would benefit from training programs such as Fast ForWord. And the data will tell use whether impaired sound discrimination can be used to predict whether infants might be at risk for later spoken language and reading problems.Read moreRead less
A Telehealth Adaptation Of A Treatment For Chronic Stuttering
Funder
National Health and Medical Research Council
Funding Amount
$389,400.00
Summary
Stuttering can have devastating effects on psychological development, social adjustment, and the realisation of educational and vocational potential. Best practice treatments for chronic stuttering in adulthood and late adolescence stop or reduce stuttering with a systematic process of speech restructuring. However, speech restructuring treatment for chronic stuttering is specialised and resource intensive. Probably half of Australians with chronic stuttering cannot access such specialised treat ....Stuttering can have devastating effects on psychological development, social adjustment, and the realisation of educational and vocational potential. Best practice treatments for chronic stuttering in adulthood and late adolescence stop or reduce stuttering with a systematic process of speech restructuring. However, speech restructuring treatment for chronic stuttering is specialised and resource intensive. Probably half of Australians with chronic stuttering cannot access such specialised treatment services because of distance and lifestyle factors, and because clinicians do not have the resources to provide the treatment. These problems present a research challenge. The present project aims to meet this challenge by developing an innovative treatment model for adults who stutter based on telehealth. This treatment model will make the treatment accessible to all rural and urban dwelling patients with chronic stuttering, and will make the treatment deliverable by every clinician. The research will have significant impact for many end users.Read moreRead less
The Contribution Of Dopamine To Regulation Of Orofacial, Limb And Trunk Control: System Or Function Specific Effects?
Funder
National Health and Medical Research Council
Funding Amount
$493,124.00
Summary
Treatment for Parkinson's disease, including dopamine replacement therapy and deep brain stimulation, fail to produce the same beneficial effects on all movement systems. Whereas limb function is the primary beneficiary of these treatments, other functions such as speech and postural control are less responsive. Critical to the research is the postulate that such differences may have arisen due to the fact that previous studies of dopamine and movement control have investigated distinct motor sy ....Treatment for Parkinson's disease, including dopamine replacement therapy and deep brain stimulation, fail to produce the same beneficial effects on all movement systems. Whereas limb function is the primary beneficiary of these treatments, other functions such as speech and postural control are less responsive. Critical to the research is the postulate that such differences may have arisen due to the fact that previous studies of dopamine and movement control have investigated distinct motor systems via the assessment of distinct movement constructs, making cross system comparisons an impossible task. The proposed research will assess the effect of Parkinson's disease, deep brain stimulation and dopamine on identical muscle functions within the orofacial, trunk and limb muscle systems. To this end, the results generated from this resarch have the potential to reconceptualise working models of brain-muscle relationships. Further the research will provide guidance for future studies that aim to eradicate trade-off effects (e.g. limb function improved but not speech) relating to symptom relief for people with Parkinson's disease.Read moreRead less
Accurate Differentiation Of Acquired Speech And Language Disorders For Positive Rehabilitation Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$398,840.00
Summary
Loss of speech due to acquired brain injury causes long-term disability, increased risk for depression, and substantial caregiver burden. Speech disorders can affect linguistic processes or control of speech movements. The current gold standard for diagnosis of speech movement disorders is expert judgment of speech characteristics. We propose to test a novel diagnostic tool that has potential to drive a reframing of rehabilitation strategies to improve outcomes and quality of life.
Home-based Speech Treatment For Parkinsons Disease Via Telerehabilitation : Clinical And Economic Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$485,793.00
Summary
Parkinson's Disease affects a person's ability to speak clearly. Speech pathologists can provide effective treatment for this speech disorder. Access to a speech pathologist, however, is difficult for many people with Parkinson's Disease due to their physical difficulties and the limited availability of speech pathology services in rural areas. This study demonstrates the use of telerehabilitation to deliver speech treatment to people with Parkinson's Disease in their own homes via the Internet.
Extraction Of Key Features Of Natural Speech By Ventral Cochlear Nucleus Neurons
Funder
National Health and Medical Research Council
Funding Amount
$225,330.00
Summary
Little is known about how speech is processed and transformed by the central auditory pathway, and how the critical temporal and spectral features that identify a speech sound segment (a phoneme) are extracted. To date, most studies have approached this issue by using synthetic speech and examined the responses of the peripheral auditory nerve only. The aim of this study is to examine how important features of naturally-spoken speech are encoded by the cochlear nucleus (CN) - the first station i ....Little is known about how speech is processed and transformed by the central auditory pathway, and how the critical temporal and spectral features that identify a speech sound segment (a phoneme) are extracted. To date, most studies have approached this issue by using synthetic speech and examined the responses of the peripheral auditory nerve only. The aim of this study is to examine how important features of naturally-spoken speech are encoded by the cochlear nucleus (CN) - the first station in the auditory pathway located in the brainstem. The CN is a complex of different cell types that have the capacity to transmit, transform, and encode complex acoustic information in different ways. The proposed experiments involve recording the bioelectrical signal from single CN cells in anaesthetised rats while presenting naturally-spoken syllables, both in quiet and in the presence of noise. It is important to examine what happens to the neural responses in the latter condition, because all animals must cope with the problem of extracting important signals from background noise. While noise clearly interferes with the perception of another sound, the auditory system is in fact quite good at extracting signals in the presence of noise. This is well demonstrated by our ability to understand speech in the presence of quite high noise levels. This ability is severely degraded in the hearing impaired. Thus, one of the aims of this study is to examine the mechanisms and limits of the CN's ability to encode speech in a noisy background. A greater understanding of the mechanisms the nervous system uses to extract critical features of speech will not only build on our knowledge of auditory brainstem processes, but may also provide clues to improving processing strategies for cochlear implants.Read moreRead less
Predictors And Correlates Of Developmental Language Problems: A Longitudinal Study From Infancy To Pre-school Age
Funder
National Health and Medical Research Council
Funding Amount
$537,750.00
Summary
Language impairment is a disabling condition, thought to affect between 7% and 15% of 4 year old children. It has serious and lasting implications for social and emotional development, cognition, behaviour and literacy. A link has been demonstrated between language impairment and later psychiatric disorders in adolescence and adulthood. Given the potential of enhancing the language development of young children, it is critical that effective prevention and early intervention programs are availab ....Language impairment is a disabling condition, thought to affect between 7% and 15% of 4 year old children. It has serious and lasting implications for social and emotional development, cognition, behaviour and literacy. A link has been demonstrated between language impairment and later psychiatric disorders in adolescence and adulthood. Given the potential of enhancing the language development of young children, it is critical that effective prevention and early intervention programs are available. However, current knowledge is liminted in that there are no entirely satisfactory methods for detecting children who at much younger ages, 8 months, 12 months, 2 years and 3 years, are at risk of later impairment. In this study we aim to: examine the risk factors (many are thought to exist) that contribute to language impairment learn more about the natural history of this disabling disorder in children between 8 months and 4 years of age Ultimately, we aim to identify early signs that might warn health professionals and parents of language impairment so that such problems can be detected much earlier. Early identification will mean that help is available at an earlier age to children who currently go on to have persisting and extremely disabling language impairment.Read moreRead less