Development And Evaluation Of A Novel Early Language Assessment Tool To Identify Vulnerable Children Who Would Benefit From Referral To Allied Health Pathways
Funder
National Health and Medical Research Council
Funding Amount
$554,388.00
Summary
Language disorder or delay are best addressed via allied health pathways. However, referral to such services requires a child's carers being able to differentiate typical and atypical development, causing high levels of over- and under-referral. We will develop an early Language and Communication tool that can be used by a child's carers to generate high-quality pre-diagnostic information, enabling appropriate and timely referral, and reducing current burdens on allied health services.
Exploiting Messenger RNA Export As A Novel Therapeutic Strategy To Treat Cancer
Funder
National Health and Medical Research Council
Funding Amount
$948,098.00
Summary
Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.
Pathways That Regulate Nuclear Export Of Circular RNA
Funder
National Health and Medical Research Council
Funding Amount
$933,327.00
Summary
An emerging and unusual class of RNA molecules, circular RNAs (circRNAs), is widespread and plays important roles in cancer initiation and progression. However, the pathways responsible for nuclear export of circRNAs are unknown. We propose here to systematically determine how circRNAs are exported from the nucleus and characterise the effect of modulating circRNA export pathways in cancer. This will enable us to determine whether circRNAs can function as a biomarker of patient response.