Audio-visual Information for Speech-hand Gestures. How does audio-visual information influence human movement and communication? We will investigate whether speech and hand gestures involve shared information about the timing of rhythmic movements. Using dynamical systems theory and brain imaging techniques, we will study rhythms that emerge during simultaneous speaking and finger tapping in both stutterers and non-stutterers, and in left-handers and right-handers. The communicative interaction ....Audio-visual Information for Speech-hand Gestures. How does audio-visual information influence human movement and communication? We will investigate whether speech and hand gestures involve shared information about the timing of rhythmic movements. Using dynamical systems theory and brain imaging techniques, we will study rhythms that emerge during simultaneous speaking and finger tapping in both stutterers and non-stutterers, and in left-handers and right-handers. The communicative interaction of two persons performing speech-hand gestures will be examined. Results will clarify how brain asymmetry affects gestural coordination in stutterers, how stuttering can be treated, and the hypothesis that speech and language evolved from a communication system based on hand gestures.
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Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less
Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The ben ....Phenotypic differences in behaviour, brain function and structure of genetically dissimilar forms of intellectual disability. How is the brain of someone with intellectual disability different from that of a normal person? Are behavioural phenotypes such as intellectual disability more related to similarities in brain structure and function than to the genotypic anomaly? This project will use neuroscience techniques of psychophysics, electrophysiology and fMRI to probe these questions. The benefit of this project is that cortical flattening fMRI techniques together with new and efficient stimulus paradigms will result in a functional landmark mapping tool capable of application to many other brain genotype-phenotype questions. Also, the functional brain basis of intellectual disability will be further revealed.Read moreRead less
Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to tran ....Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to transfer genes into cochlear tissue, as well as development of gene cassettes for effective neural repair. The work will advance the field of bionics, an area where Australia is establishing international preeminence.Read moreRead less
Cognitive and neural mechanisms underlying lateral biases in human vision. Under conditions of unconstrained viewing, humans show a consistent and reliable asymmetry in their perception of visual stimuli. This bias, which favours the left side, arises at a post-retinal level and is hypothesised to reflect hemispheric asymmetry in the control of visuospatial attention. This program of research investigates the mechanisms underlying lateral biases in visual perception, using the latest cognitive n ....Cognitive and neural mechanisms underlying lateral biases in human vision. Under conditions of unconstrained viewing, humans show a consistent and reliable asymmetry in their perception of visual stimuli. This bias, which favours the left side, arises at a post-retinal level and is hypothesised to reflect hemispheric asymmetry in the control of visuospatial attention. This program of research investigates the mechanisms underlying lateral biases in visual perception, using the latest cognitive neuroscience techniques. The findings will provide important new information about the neural and cognitive bases for normal and disordered visuospatial perception. The goal is to develop a novel test of perceptual asymmetries for use in normal participants and neurological patients.Read moreRead less
Attentional biases that underlie free-viewing perceptual asymmetries: Endogenous and exogenous effects in a behavioural/imaging study. As we move our eyes and attention around us, we are capable of interacting with any part of our immediate environment. It is intriguing, therefore, to discover that the upper and leftward features of an object are more salient than those on the bottom or right. By investigating the nature of these attentional biases in normal individuals, this research will impro ....Attentional biases that underlie free-viewing perceptual asymmetries: Endogenous and exogenous effects in a behavioural/imaging study. As we move our eyes and attention around us, we are capable of interacting with any part of our immediate environment. It is intriguing, therefore, to discover that the upper and leftward features of an object are more salient than those on the bottom or right. By investigating the nature of these attentional biases in normal individuals, this research will improve our understanding of the thought processes and brain structures that control spatial attention. This research has important implications for the development of remedial programs for patients with attentional disorders. The test we use to measure attentional asymmetries has the potential to become an important tool for the early detection of clinical abnormalities in attention.
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Left of centre: Attentional distortions in the mental representation of space in healthy and clinical populations. Stroke patients cost the Australian economy $1.3bn pa in addition to their social burden, but effective diagnosis and rehabilitation is impeded by a lack of fundamental research into the cognitive and neural mechanisms that underlie attentional disorders. Our research will provide significant new insights into how the brain deploys attention in external and imagined space and will l ....Left of centre: Attentional distortions in the mental representation of space in healthy and clinical populations. Stroke patients cost the Australian economy $1.3bn pa in addition to their social burden, but effective diagnosis and rehabilitation is impeded by a lack of fundamental research into the cognitive and neural mechanisms that underlie attentional disorders. Our research will provide significant new insights into how the brain deploys attention in external and imagined space and will lead to more effective management and treatment of stroke victims. Our new test of attentional disorders is independent of a patient's inability to see or move and will enable more effective diagnosis. Our research provides the fundamental knowledge base for our discipline and is vital for developing the next generation of Australia's cognitive neuroscientists. Read moreRead less
Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will ....Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will be related to the properties of neurones in those areas and to those of individual input and output fibres. An optical imaging equipment will be acquired in 2004 using a recently awarded LIEF grant to the CI.Read moreRead less
Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, ....Functional Electronic Stimulation of Muscles - Development of a Model for Sensory Feedback to Amputees and Vision for the Blind. Electrical stimulation of nerve fibres is an emerging physiological technique with great promise towards rehabilitation. The field lacks techniques for detailed, focal application of stimuli to recruit specific fibres for fine muscle control or conveying useful neurosensory information. The investigator has developed microtechnology for delivering stimuli to 100 sites, conceivably facilitating recruitment of specific fibres within a given bundle. Effects of muscle stimulation are readily measured and shall be used to model and refine techniques for generic high-resolution fibre recruitment. Benefits include, improved muscle control in functional electrical stimulation, sensory perception for amputees and patterned vision from optic nerve stimulation.Read moreRead less
Large-scale Parallelization of Neural Stimulation in a Visual Prosthesis. Over time, engineers have been able to treat a large number of disorders through new technologies. For example, the deaf can now hear again through cochlear implants. Similar efforts to provide vision to the blind, however, have met with difficulties owing to the high quantities of sites that must be stimulated to provide 'useful' vision. This study addresses the important issues relating to the delivery of large quantitie ....Large-scale Parallelization of Neural Stimulation in a Visual Prosthesis. Over time, engineers have been able to treat a large number of disorders through new technologies. For example, the deaf can now hear again through cochlear implants. Similar efforts to provide vision to the blind, however, have met with difficulties owing to the high quantities of sites that must be stimulated to provide 'useful' vision. This study addresses the important issues relating to the delivery of large quantities of electrical stimulations to surviving nerves in the eyes of blind patients in an effort to devise a beneficial visual prosthesis or 'bionic eye'. The outcomes of this study could substantially enhance Australia's already prominent reputation in neurostimulation and provide much needed treatments to vision disorders.Read moreRead less