Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may resul ....Prevention and treatment of chlamydiosis and cryptococcosis in koalas. This project aims to generate increased understanding of the aetiology and pathogenesis of the two most prevalent and debilitating infectious diseases of koalas to make improved decisions regarding therapeutic intervention, prevention and management. Chlamydiosis, caused by two chlamydial bacteria, affects koala fertility, urinary tract function and eyesight. Cryptococcosis, caused by the fungus Cryptococcus gattii, may result in koala morbidity and death. Planned therapeutic trials, prevention strategies and the development of optimal husbandry strategies will provide knowledge that will lead to reduced koala morbidity through improved understanding of the interactions amongst infectious pathogens, the animal host and the environment.Read moreRead less
Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical tr ....Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical training as there is no capacity in conventional training to cope with student numbers. This research will develop and evaluate new models of training incorporating standardised patients (actors) and simulators (mannequins) which increase education capacity. Models are transferable to other health professions.Read moreRead less
Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of rese ....Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of research outcomes and the contribution this project makes to high value employment in the biotechnology sector.Read moreRead less
Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social dev ....Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social development, and academic outcomes, the community benefits arising will be greatly improved quality of life for these individuals and significant savings to society. In partnership with Cochlear Ltd, this study will provide some of the first data worldwide comparing the effects of an additional implant on language, social and educational outcomes.Read moreRead less
Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide t ....Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide the foundation for a commercial service of automatic Speaker Diarisation to be developed, growing Australia's impact on the information and communications technology (ICT) sector. The outcome of this research will also assist in the tracking of terrorist and unlawful activity by enabling effective intelligence gathering from different audio sources.Read moreRead less
Establishing Guidelines for Coronial Best Practice Use of Internal Autopsy. Last year in Queensland 2700 Coronial internal autopsies were conducted at a cost of $5.3 million. In addition to the economic cost, other relevant concerns include few qualified personnel, public health risks, and cultural and religious sensitivities associated with internal autopsy. Anecdotal evidence suggests that for a number of these deaths, the internal autopsy was not necessary to establish cause or circumstance ....Establishing Guidelines for Coronial Best Practice Use of Internal Autopsy. Last year in Queensland 2700 Coronial internal autopsies were conducted at a cost of $5.3 million. In addition to the economic cost, other relevant concerns include few qualified personnel, public health risks, and cultural and religious sensitivities associated with internal autopsy. Anecdotal evidence suggests that for a number of these deaths, the internal autopsy was not necessary to establish cause or circumstance of death. The purpose of this research is to create guidelines to enable coroners to weight all sources of evidence before ordering internal autopsies The purpose is to decrease the number (and associated costs, risks and distress to families) of unnecessary internal autopsies being performed without compromising the finding as to cause and circumstance of death.Read moreRead less
Fusion of digital microscopy and plain text reports for automated analysis. The project aims to develop advanced computer-aided analytics systems with the goal to improve the workflow and automation in the pathology industry. Improvements will be achieved by fusing information from both digital images and plain text medical reports. In collaboration with a partner organisation, the project team will field trial the new analytics systems against traditional pathology tests to evaluate both effica ....Fusion of digital microscopy and plain text reports for automated analysis. The project aims to develop advanced computer-aided analytics systems with the goal to improve the workflow and automation in the pathology industry. Improvements will be achieved by fusing information from both digital images and plain text medical reports. In collaboration with a partner organisation, the project team will field trial the new analytics systems against traditional pathology tests to evaluate both efficacy and reliability. In addition, the project is also aimed to construct a large digital slide databank which will aid training and education. The expected outcome of the project is to perform existing tasks cheaper and more efficiently. Read moreRead less
Making demonstrably reliable forensic voice comparison a practical everyday reality in Australia. To assist Australian law-enforcement agencies and courts in the process of the conviction of the guilty and the exoneration of the innocent, this project will develop and test a practical and demonstrably reliable forensic voice comparison system for use with Australian voices. This will allow forensic scientists to produce reliable strength of evidence statements for presentation in court using the ....Making demonstrably reliable forensic voice comparison a practical everyday reality in Australia. To assist Australian law-enforcement agencies and courts in the process of the conviction of the guilty and the exoneration of the innocent, this project will develop and test a practical and demonstrably reliable forensic voice comparison system for use with Australian voices. This will allow forensic scientists to produce reliable strength of evidence statements for presentation in court using the same evaluative framework as used with DNA. In addition, application of the system during criminal investigations may lead to the refocussing of investigations on other suspects, or may help leverage guilty pleas, thus saving substantial time and money.Read moreRead less
Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhi ....Pharmacological modification of retinal and visual function and relation to control of refractive error. Myopia (short-sightedness) affects many hundreds of millions of people worldwide and can lead to blindness. Drug treatments that prevent myopia are being developed, however there is no efficient way of determining who is at risk of myopia or who will benefit from these treatments. This fundamental research project will determine the retinal and visual effects of pharmacologic agents that inhibit myopia, with the aim of determining an ocular measure that is related to myopia, which is altered by drugs that are known to slow myopia progression, and that could be used as an indication of an agent's likely effectiveness.Read moreRead less
Audio Visual Speech Recognition. Even though significant advances have been made in automatic speech recognition using acoustic information, the recognition accuracies are still poor in noisy and hostile environments such as in crowds, traffic, factory floors etc. In many of these applications visual information is or can easily be made available in addition to the audio. The aim of this project is to achieve an order of magnitude improvement in speech recognition accuracies in adverse environme ....Audio Visual Speech Recognition. Even though significant advances have been made in automatic speech recognition using acoustic information, the recognition accuracies are still poor in noisy and hostile environments such as in crowds, traffic, factory floors etc. In many of these applications visual information is or can easily be made available in addition to the audio. The aim of this project is to achieve an order of magnitude improvement in speech recognition accuracies in adverse environments by joint processing and modelling of the acoustic modality with visual information in the form of lip shapes and movements. The outcomes will be useful in human computer interaction in adverse environments as well as in the transcription and mining of multimedia data.
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