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An International Whole Genome Study To Definitively Map Heritable Risk In Sarcomas
Funder
National Health and Medical Research Council
Funding Amount
$836,550.00
Summary
We want to understand why some people get sarcomas, and others do not. This is likely due to genetic causes, because these cancers affect the young. We now have the tools to address this question, and have created the largest and best characterised study of sarcoma families in the world upon which to apply these tools. This project will create an enduring foundation for research into the genetic basis of sarcomas for the next 20 years.
New Treatments For Epitheliod Inflammatory Myofibroblastic Sarcoma
Funder
National Health and Medical Research Council
Funding Amount
$647,267.00
Summary
Epithelioid Inflammatory myofibroblastic sarcoma (eIMS) is a rare aggressive cancer, most common in of childhood and young adults. This cancer has been scarcely studied due to its rarity and is not cured by standard chemotherapeutic regimes. Our investigations will extensively characterise eIMS samples from recently diagnosed patients, and apply a new laboratory model to discover more effective drugs and improve treatment outcomes.
Highly multiplexed rapid-analysis microarrays for early disease diagnosis. Molecular diagnostics are revolutionising the treatment of disease in hospitals by providing rapid and accurate identification of pathogens; saving costs, time and lives. This project will accelerate this revolution by combining new array technology from the University of Sydney with a proven multiplex method from the Sydney based company, AusDiagnostics.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453935
Funder
Australian Research Council
Funding Amount
$220,106.00
Summary
Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capa ....Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capacity for research (volumes between 1 ml and 1000 L), offer a vertically integrated system to facilitate step-wise scale-up, allow more accurate modelling of industrial fermentations, enable greater adoption of high-throughput formats and technologies, and achieve enhanced productivity through increased system automation.Read moreRead less
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
The Role Of Stem-progenitor Cells In Regeneration Of Mouse Endometrium.
Funder
National Health and Medical Research Council
Funding Amount
$311,938.00
Summary
The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process is not well understood. For the first time stem cells have been identified within human endometrium that are likely to be responsible for its remarkable regeneration. The aim of this project is to identify stem cells within the mouse endometrium, to use as a model to understand how the endometrium restores each month after menstruation.
Genetic and environmental basis for endosperm hardness in malting barley. Barleys with a hard endosperm do not malt as well as other barleys, leading to under-modified malt. While malts may appear to be satisfactory by bulk chemical analysis, even relatively small amounts of under-modified malt causes problems in the brewing industry, such as slow filtration rates and increasing haze formation. We aim to examine two new procedures potentially useful in determining heterogeneity in barley hardn ....Genetic and environmental basis for endosperm hardness in malting barley. Barleys with a hard endosperm do not malt as well as other barleys, leading to under-modified malt. While malts may appear to be satisfactory by bulk chemical analysis, even relatively small amounts of under-modified malt causes problems in the brewing industry, such as slow filtration rates and increasing haze formation. We aim to examine two new procedures potentially useful in determining heterogeneity in barley hardness by examining single kernels, and investigating the role of barley variety and growing conditions on hardness.This project will aid in the production and selection of more uniform barleys for the malting and brewing industries.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Central Neural Circuits Subserving Nutrient–activated Thermogenesis - The Basis Of Post Prandial Energy Expenditure
Funder
National Health and Medical Research Council
Funding Amount
$766,207.00
Summary
Studies of “energy burning” brown fat, including its importance in the determination of obesity in humans and the potential to increase its capacity by turning white fat into brown-like fat are currently foremost in obesity research. Here we study the detail of brain pathways that dictate brown fat activity after a meal resulting in the burning of ingested calories and reduction of body weight. The results will give us a better idea of how we can harness brown fat to combat obesity.