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Identification Of Cancer Initiating Cells In Small-cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$364,420.00
Summary
Lung cancer is the leading cause of cancer deaths worldwide. Recently a unique mouse model of small-cell lung cancer (SCLC) has been generated that closely mimics the human disease. We will use this model to identify the cells that give rise to SCLC upon genetic alteration. Results obtained will assist in designing more effective intervention strategies aimed at overcoming initial and acquired resistance of these tumours against cytotoxic and targeted drugs.
Use Of Molecular Tumour Markers To Improve Diagnostic Performance Of Bronchoscopy In Assessment Of Pulmonary Nodules And Early Diagnosis Of Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
Pulmonary nodules may represent early lung cancer though difficulty in accurate diagnosis means many patients experience delayed diagnosis, or unnecessary surgical biopsy or repeat CT imaging (& consequent radiation exposure). I will identify molecular (DNA, protein) markers in bronchoscopic & blood specimens to accurately characterize malignant & benign nodules. These biomarkers will also be investigated for their value as a non-invasive screening test for lung cancer
Real-time In-vivo Imaging During Lung Cancer Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung tumours move in clinically significant and unpredicable ways. Current radiotherapy is limited by the lack of real-time imaging to monitor tumour motion. The aim of this project is to develop and clinically implement Real-time In-vivo Imaging to enable motion-adaptive radiotherapy and thereby improve treatment outcomes. Real-time In-vivo Imaging is a software technology that will be applicalbe to 90% of modern radiotherapy systems globally and will enable wide access to advanced cancer care.
Enhancing The Anti-Cancer Immune Response By Combining Radiotherapy And Immunotherapy
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Lung cancer is the biggest cause of cancer related death in Australia. Recently, immune therapies have shown promise by unlocking the body’s own defenses to fight against lung cancer. I aim to maximise the effect of the anti-PD-1 immune therapy by ‘kick-starting’ the immune response with high-precision stereotactic ablative body radiotherapy (SABR). By completing clinical trials and biological research into the combination of therapies I hope to improve outcomes for patients with lung cancer.
Optimizing Lung Cancer Diagnostic And Staging Pathways Through The Innovative Use Of Thoracic Imaging
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
This research aims to simplify the initial work-up for lung cancer diagnosis. Currently most patients undergo complex investigations and multiple biopsies. Common imaging technology e.g. ultrasound, PET and CT scans may help choose the best and least invasive biopsy procedure. My research will explore this through three complementary studies. If positive, >10000 Australians with lung cancer will benefit each year, and the majority of them will only have to undergo one biopsy procedure.
Development Of Prognostic And Predictive Biomarkers To Aid Treatment Of Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$188,226.00
Summary
Although a number of new therapies are emerging in the treatment of lung cancer, chemotherapy remains the backbone of treatment for most patients. Currently we are unable to predict who will benefit from chemotherapy with some patients deriving no benefit but experiencing significant toxicity. Our group has investigated a number of biomarkers and found them to predict response to chemotherapy. These markers may be used to determine patients most likely to derive benefit from chemotherapy.
Defining Steps In The Molecular Pathogenesis Of Lung Cancer Using Immortalized Human Bronchial Epithelial Cells
Funder
National Health and Medical Research Council
Funding Amount
$374,344.00
Summary
Lung cancer remains the leading cause of cancer death worldwide and is caused by abnormalities in DNA. This project aims to further our understanding of this disease by altering known cancer-related genes and studying their effect on lung cancer development. This project also aims to identify novel genes in lung cancer as well as tumour expression profiles which can predict response to chemotherapy agents. In summary, this research will identify new gene targets for therapeutic agents.
Characterising The Mechanisms That Control Blood Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$335,616.00
Summary
Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as can ....Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as cancer.Read moreRead less