The atlas of trace metals in the mouse brain: a new tool for neuroscientists. This project will produce the first atlas of trace metals in the mouse brain: a set of 'maps' of a type of brain often used to study diseases affecting the human brain. This online resource will show neuroscientists unprecedented 3D detail of the distribution in the brain of trace metals, which are implicated in such diseases as Parkinson's and Alzheimer's.
Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Australian art exhibitions 1968-2009: a generation of cultural transformation. The years 1968 to 2009 witnessed a transformation in the way Australians saw the art of their country. This project investigates the impact of increased funding (government and private) and new scholarship on the curating of art exhibitions, and traces the reconfiguration of Australia’s art history that took place in exhibitions during this period.
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need ....A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need better preservation. Conservators do not have much expertise in preserving plastics, which are contemporary and have a relatively short life expectancy. This project intends to provide museums with a model for prioritising and effectively allocating resources to preserve a vulnerable group of collections for future generations.Read moreRead less
The invisible farmer: Securing Australian farm women's history. The invisible farmer: Securing Australian farm women's history. This project, believed to be the first national study of farm women in Australia, aims to address their historical and contemporary invisibility by creating an online, publicly accessible, multimedia documentary database that maps the role women play/played in Australian agriculture. Chief investigators in the fields of social work, women's history, cultural informatics ....The invisible farmer: Securing Australian farm women's history. The invisible farmer: Securing Australian farm women's history. This project, believed to be the first national study of farm women in Australia, aims to address their historical and contemporary invisibility by creating an online, publicly accessible, multimedia documentary database that maps the role women play/played in Australian agriculture. Chief investigators in the fields of social work, women's history, cultural informatics and archival practice will collaborate with community, government and cultural organisations to create digital tools for research, public access and community engagement. Reframing the narrative of rural Australia is expected to create greater understanding and awareness of the value of inclusion, reveal structures of gender inequality in rural communities, and enable significant outcomes in research, industry and public policy.Read moreRead less
Curating Museum Collections for Climate Change Mitigation. The Project aims to investigate how museum collections, many of which have histories entangled in Australia’s high emission sectors that supported the nation’s economic growth, can be curated to support climate change mitigation. Drawing together the disciplines of biogeochemistry, museology, environmental humanities, Indigenous knowledge and education, the Project anticipates enhancing the Museum of Applied Arts and Sciences' capacity f ....Curating Museum Collections for Climate Change Mitigation. The Project aims to investigate how museum collections, many of which have histories entangled in Australia’s high emission sectors that supported the nation’s economic growth, can be curated to support climate change mitigation. Drawing together the disciplines of biogeochemistry, museology, environmental humanities, Indigenous knowledge and education, the Project anticipates enhancing the Museum of Applied Arts and Sciences' capacity for climate action through innovative programs. Its benefits include developing new collections-based climate research which incorporate the perspectives of multi-stakeholders, including Indigenous Australians, and builds museums' capacity to grow public climate literacy.Read moreRead less
Communication skills training for oncology health care professionals working with culturally and linguistically diverse patients. The project will develop and evaluate two novel training programs designed to equip health professionals to communicate with cancer patients from different cultures. It is expected that the programs will improve trainees’ ability to communicate in a culturally sensitive way.
The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present a ....The role of SGK-1 and SGK-2 in hypertension and nephropathy in diabetes mellitus. The key objective is to define the suitability of the serum glucocorticoid regulated kinases -1 and -2 (SGK-1, -2) as novel drug discovery targets. A specific inhibitor targeting SGK-1 and -2 will be tested to determine if it reverses the enhanced sodium reabsorption and extracellular matrix production characteristic of progressive renal failure in in vitro models models of renal disease. These inhibitors present an opportunity to control hypertension whilst simultaneously limiting fibrosis in the kidney. Renal failure is steadily increasing and is now the single largest health care cost to the community. These studies will provide the proof of concept required to ultimately bring this novel preventative therapy to the community.Read moreRead less
Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantif ....Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantify the interactive impact of temperature and nutrition on immune function, disease resistance and host-plant quality of plague locusts; and to explore the combined effects of temperature, habitat and Green Guard, in combination with candidate microbes or pathogens, on the behaviour and collective movement of locusts. It is anticipated that this will have implications for management and control strategies.Read moreRead less