Discovery Early Career Researcher Award - Grant ID: DE140101530
Funder
Australian Research Council
Funding Amount
$372,744.00
Summary
Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotr ....Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.Read moreRead less
Molecular dynamics of steroid receptor crosstalk. This project uses state-of-the-art technology to show how steroids (for example, testosterone) affect many aspects of human life, and how these can be disrupted by chemicals and synthetic hormones. The results can be used to interpret disease, predict safety of new drugs, and to monitor risk to humans and wildlife of environmental chemicals.
Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding o ....Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding of changes in brain function and plasticity with advancing age is expected to help to optimise the design of preventative programs aimed at rejuvenating motor and cognitive function in the elderly.Read moreRead less
Managing uncertainty in RFID traceability networks. Australia suffers 5.4 million cases of food-borne illness every year, which leads to 2.1 million days of lost work, 1.2 million people visiting a doctor, and 120 deaths annually. This has revealed the urgent need for improved ways of locating and recalling problematic products that have been released into the community. The project will develop novel techniques driven by Radio Frequency Identification (RFID) technology for improving the effici ....Managing uncertainty in RFID traceability networks. Australia suffers 5.4 million cases of food-borne illness every year, which leads to 2.1 million days of lost work, 1.2 million people visiting a doctor, and 120 deaths annually. This has revealed the urgent need for improved ways of locating and recalling problematic products that have been released into the community. The project will develop novel techniques driven by Radio Frequency Identification (RFID) technology for improving the efficiency and accuracy of product tracking in distribution networks. This project will place Australia at the forefront of RFID research. It will also be an excellent vehicle for educating young researchers and engineers in Australia.Read moreRead less
Understanding Ageism in Australia. Ageism refers to stereotypes, prejudice and discrimination towards people based on their age. This project aims to generate new knowledge in relation to older Australians’ experiences of ageism by conducting a population-based survey of ageism and examining its links with mental health and wellbeing. The project will also use intensive longitudinal methods to study everyday ageism. Expected outcomes include identification of at-risk groups that can be used to i ....Understanding Ageism in Australia. Ageism refers to stereotypes, prejudice and discrimination towards people based on their age. This project aims to generate new knowledge in relation to older Australians’ experiences of ageism by conducting a population-based survey of ageism and examining its links with mental health and wellbeing. The project will also use intensive longitudinal methods to study everyday ageism. Expected outcomes include identification of at-risk groups that can be used to inform government policy responses to tackling ageism and will inform the development of interventions and education programs to reduce ageism in the community. This should provide significant benefits for social inclusion, intergenerational solidarity and economic participation Read moreRead less
Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to ....Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to better quality of life, reduce the need for institutional care and reduce public health costs. They will also provide environmental benefits through reduced energy use and carbon emissions.Read moreRead less
Resilient ageing and the oldest-old in the Australian longitudinal study of ageing. This project will provide a better understanding of resiliency (positive adaptation) in oldest-old Australians (85 plus). At a time in history when the population is ageing at an unprecedented rate, understanding how the oldest-old respond adaptively to age-related challenges is critically important to informing ageing policies and service provision.
Reconnecting the ageing brain to enhance plasticity and motor learning. The ability to execute and learn skillful actions deteriorates with advancing age, but the cause remains elusive. The main aim of this project is to use new neurophysiological techniques to examine the age-related changes in brain function that contribute to reduced movement control in healthy older adults. The research will use multimodal approaches to reveal the causal role of age-related changes in specific brain networks ....Reconnecting the ageing brain to enhance plasticity and motor learning. The ability to execute and learn skillful actions deteriorates with advancing age, but the cause remains elusive. The main aim of this project is to use new neurophysiological techniques to examine the age-related changes in brain function that contribute to reduced movement control in healthy older adults. The research will use multimodal approaches to reveal the causal role of age-related changes in specific brain networks to motor behaviour and learning. The outcomes will provide significant new knowledge that may help to optimise the design of targeted interventions aimed at rejuvenating brain function and movement quality in the elderly.Read moreRead less
Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/death ....Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/deaths, risk factors/behaviours, and human rights issues. Outcomes benefiting the Australian community are improved prediction/characterisation of product safety issues for older Australians informing safer product design and use, targetted regulatory responses, ageing-in-place strategies, and creating safer home environments.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples' social networks that occur with age, and the effects of these changes on health and well being in later life. The project will use information collected from several ongoing Australian studies of ageing, and will have important implications for social policy in Australia.