Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453832
Funder
Australian Research Council
Funding Amount
$550,910.00
Summary
New directions in biomolecular mass spectrometry. The combined UoW/ANU mass spectrometry facility supports a range of research projects in high priority areas including proteomics, mechanisms of aging, anticancer drugs and pathogenicity. The facility has several key deficiencies: 1) the ability to study very high molecular weight biomolecular complexes, 2) the ability to study ion-molecule interactions that have implications in mechanisms of chemistry in nature, and 3) researchers at ANU lack es ....New directions in biomolecular mass spectrometry. The combined UoW/ANU mass spectrometry facility supports a range of research projects in high priority areas including proteomics, mechanisms of aging, anticancer drugs and pathogenicity. The facility has several key deficiencies: 1) the ability to study very high molecular weight biomolecular complexes, 2) the ability to study ion-molecule interactions that have implications in mechanisms of chemistry in nature, and 3) researchers at ANU lack essential walk-up access to high sensitivity protein sequence analysis (MS/MS). The placement of resources that address these deficiencies in one geographical region and collaboration between these institutions will produce a research interaction unique in Australia.Read moreRead less
The twentieth century in paint. The art market is a major contributor to the Australian economy worth over $500M per annum. However many modern works created with new materials introduced in the 20th century in Australia and Southeast Asia exhibit problems with deterioration, and there is little research on the use and effects of these materials. Without answers to material based preservation questions collectors, curators and conservators cannot make informed decisions. This project, with partn ....The twentieth century in paint. The art market is a major contributor to the Australian economy worth over $500M per annum. However many modern works created with new materials introduced in the 20th century in Australia and Southeast Asia exhibit problems with deterioration, and there is little research on the use and effects of these materials. Without answers to material based preservation questions collectors, curators and conservators cannot make informed decisions. This project, with partners in Australia, Asia, US and UK will provide fundamental information to assist in formulating management strategies, inform curatorship and develop innovative approaches to conservation and the manufacture of art materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882382
Funder
Australian Research Council
Funding Amount
$245,000.00
Summary
Biophysical Characterisation Facility. The protein analysis facility will have substantial benefits for basic science and biotechnology. It will create capacity for South Australian researchers to study proteins at the biophysical level. The facility will support research projects within the designated national research priority areas of 'Frontier technologies for building and transforming Australian industries' and 'Promoting and maintaining good health
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775482
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Ultratrace element and isotope analysis facility. Analysis of trace concentrations of contaminants in food, water and biota is essential for proper environmental and human health protection, and the ability to analyse different isotopes of nutrients will improve our capability to develop techniques to fortify foods with essential micronutrients. The instrumentation will also assist our understanding of the geological processes, climate and environmental change and the formation and location of m ....Ultratrace element and isotope analysis facility. Analysis of trace concentrations of contaminants in food, water and biota is essential for proper environmental and human health protection, and the ability to analyse different isotopes of nutrients will improve our capability to develop techniques to fortify foods with essential micronutrients. The instrumentation will also assist our understanding of the geological processes, climate and environmental change and the formation and location of mineral deposits having economic potential in Australia. By improving forensic identification techniques, the instrumentation will allow identification and tracking of environmental contamination of the food chain and water supplies, and to identify and track criminal and terrorist activity. Read moreRead less
Mass spectrometry to reveal the role of lipids in protein misfolding. This project aims to develop an integrated mass spectrometry-based approach to determine structures and dynamics of membrane associated proteins, and discover how lipids cause protein misfolding implicated in neurodegeneration. Lipid membranes may influence protein (mis)folding, aggregation and related toxicity. However, the complex and dynamic nature of the lipid-protein interactions involved means traditional methods cannot ....Mass spectrometry to reveal the role of lipids in protein misfolding. This project aims to develop an integrated mass spectrometry-based approach to determine structures and dynamics of membrane associated proteins, and discover how lipids cause protein misfolding implicated in neurodegeneration. Lipid membranes may influence protein (mis)folding, aggregation and related toxicity. However, the complex and dynamic nature of the lipid-protein interactions involved means traditional methods cannot easily characterise them, and they are poorly understood at a molecular level. The project expects to develop tools to bridge a critical gap in structural biology, while understanding lipid-protein interactions could lead to new therapies. This will ultimately provide benefits such as reduced health costs and better health outcomes.Read moreRead less
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less