Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Development of environmentally-friendly bioinsecticides for control of Australian crop pests. Insect pests cause over $3 billion of damage each year to Australian crops. Current insecticides are becoming less effective, and they often have adverse environmental impacts. This project aims to develop a new generation of environmentally-friendly insecticides that can be used to control insect pests on farms and around the home and garden.
Heritage of the air: how aviation transformed Australia. This project aims to generate new understandings of how aviation has transformed Australian society over the last hundred years, and how the technology of global mobility has shaped people, cultures and communities. Whilst aviation has transformed Australian society over the last hundred years, its heritage is under-appreciated and at risk. The project will build a partnership between the aviation industry, community groups, museums and a ....Heritage of the air: how aviation transformed Australia. This project aims to generate new understandings of how aviation has transformed Australian society over the last hundred years, and how the technology of global mobility has shaped people, cultures and communities. Whilst aviation has transformed Australian society over the last hundred years, its heritage is under-appreciated and at risk. The project will build a partnership between the aviation industry, community groups, museums and a multidisciplinary academic team to develop fresh insights from under-utilised sources of aviation heritage, communicate their unique stories to the public through innovative exhibitions and publications, and help conserve it for future generations. As a result, the project will make an important contribution to culture and society by enabling community access to neglected and at-risk sources of aviation heritage, and engage the public’s fascination with aviation through new interpretations of its extraordinary social and cultural impact.Read moreRead less
Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Ross River virus - identification of virulence determinants in clinical isolates from across Australia. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucida ....Ross River virus - identification of virulence determinants in clinical isolates from across Australia. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucidate whether there is any association between RRV strain and the severity of human disease. It will also identify viral markers that could assist public health officials in determining likely disease outcomes of outbreaks and could provide new avenues for the design of antiviral strategies.Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs ....Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs and forge partnerships with the Netherlands, Britain, Denmark, Germany, Sweden, Indonesia, Malaysia, and South Africa, strengthening national capacity. Our analysis will enrich the value of collections, provide narratives for museums and sites, and revitalise content for international and domestic tourism markets.Read moreRead less
Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboratio ....Novel strategies in the design and development of antivirals against dengue virus. Globally, there are 50-100 million cases of dengue fever, with 500,000 cases of the more severe dengue haemorrhagic fever, each year. Australia has between 100 and 900 cases of dengue infection annually, often from travellers, but disease outbreaks occur in northern Australia. Effective anti-viral treatment will reduce disease burden. The project contributes to an evidence-based drug design program in collaboration with Australia's leading biotechnology industries. As a biotechnology industry project developing treatments for an emerging disease, it contributes to the national research priorities of Frontier technologies for building and transforming Australian industries, Promoting and maintaining good health and Safeguarding Australia.Read moreRead less
Settling well in regional Australia: Experiences of people from refugee backgrounds. Regional humanitarian settlement is a key priority across all levels of government in Australia. This study aims to provide the first longitudinal assessment of the impacts of regional settlement for humanitarian migrants and destination communities. Its innovative, mixed-method and multi-sited approach will generate new knowledge of the opportunities and challenges for sustainable regional settlement. Expected ....Settling well in regional Australia: Experiences of people from refugee backgrounds. Regional humanitarian settlement is a key priority across all levels of government in Australia. This study aims to provide the first longitudinal assessment of the impacts of regional settlement for humanitarian migrants and destination communities. Its innovative, mixed-method and multi-sited approach will generate new knowledge of the opportunities and challenges for sustainable regional settlement. Expected outcomes include enhanced community, organisational and government decision-making capacity. By guiding end-users’ current and future actions, the study has strong potential to support the wellbeing of humanitarian migrants and to contribute to healthy and resilient regional communities.Read moreRead less