Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances wil ....Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances will have a significant impact on our healthcare costs and the quality of life for all Australians.Read moreRead less
Multi-drug dry powder inhalation systems for the effective treatment of chronic obstructive pulmonary disease. Utilising a combination of particle engineering, computer modeling, rapid prototyping and high-speed 3D imaging this project will develop a novel approach to treat chronic obstructive pulmonary disease. A multi-drug particle system whose surface is independent of the drugs incorporated will be optimised in a novel high efficiency inhalation device.
Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation p ....Discrete particle simulation of powder dispersion in pharmaceutical aerosol inhalers. A successful completion of the project will i) greatly enhance the Australian R&D profile and capabilities of both computational modelling and pharmaceutical aerosol research in the world; ii) provide an improved delivery of therapeutic dose to patients via inhalers with better performance to enhance the therapeutic benefits; iii) enable wide availability of inexpensive and effective pharmaceutical inhalation products to the Australian community for the treatment of asthma and other diseases, iv) facilitate environmentally friendly technology since powder aerosol delivery does not require any harmful organic solvents to operate.Read moreRead less
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol a ....Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery. The project aim is to develop a state of the art technology for the efficient, reliable and economical production of nanoparticles of drugs suitable for inhalation delivery to the lung. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. The project will focus on both the production process and the particle properties for aerosol administration. Successful development of the technology will not only gain new knowledge in the key area of nanotechnology, but also lead to better inhalation therapy to benefit patients.Read moreRead less
Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung inf ....Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery. A successful conclusion of this project will enhance substantially the competitiveness of Australia's research in functional nanomaterials and advanced biomaterials. The Australian pharmaceutical industry will gain through the ability to develop proprietary pharmaceutical formulations targeted towards taking advantage of the novel process. Patients of asthma, lung infection and other serious health problems will benefit from an improved delivery of therapeutic dose at a much reduced cost. The technology is environmentally friendly as powder aerosol delivery does not require any harmful organic solvent to operate.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Synthesis of oligomers in dense carbon dioxide. The aim of the project is to develop a novel technique for the synthesis of low molecular weight polymers (oligomers) using dense carbon dioxide as a polymerisation solvent. The use of elevated pressure is the major impediment to the commercialisation of such technology. The technique proposed in this project will enable oligomers to be produced at greatly reduced operating pressures and may lead to a more general procedure for conducting other t ....Synthesis of oligomers in dense carbon dioxide. The aim of the project is to develop a novel technique for the synthesis of low molecular weight polymers (oligomers) using dense carbon dioxide as a polymerisation solvent. The use of elevated pressure is the major impediment to the commercialisation of such technology. The technique proposed in this project will enable oligomers to be produced at greatly reduced operating pressures and may lead to a more general procedure for conducting other types of polymer synthesis in dense carbon dioxide.Read moreRead less
Process for treatment of fluorine-containing synthetic greenhouse gases. It is generally agreed that increasing levels of greenhouse gases in the atmosphere are leading to higher average atmospheric temperatures. This research pursues the development of an energy-efficient, non-destructive process for transforming fluorine-containing greenhouse gases (GHGs) into valuable and environmentally benign products. The application of research will lead to the development of a new non-destructive proce ....Process for treatment of fluorine-containing synthetic greenhouse gases. It is generally agreed that increasing levels of greenhouse gases in the atmosphere are leading to higher average atmospheric temperatures. This research pursues the development of an energy-efficient, non-destructive process for transforming fluorine-containing greenhouse gases (GHGs) into valuable and environmentally benign products. The application of research will lead to the development of a new non-destructive process and will benefit Australia, socially by reducing emission of GHGs and thus protecting the environment, and economically through licensing of the technology for treatment of the growing stockpiles of synthetic GHGs.
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A Comprehensive Kinetic Model for Sulfur Reactions in Combustion, Gasification, and Chemical Processing. Sulfur chemistry in high temperature processes is poorly understood, leading to uncertainties in the design of these processes and in the control of their emissions. In particular, new approaches to lowering greenhouse emissions which depend on the combustion and gasification of coal, biomass, or refuse-derived fuel, such as integrated gasification combined cycle processes, are especially aff ....A Comprehensive Kinetic Model for Sulfur Reactions in Combustion, Gasification, and Chemical Processing. Sulfur chemistry in high temperature processes is poorly understood, leading to uncertainties in the design of these processes and in the control of their emissions. In particular, new approaches to lowering greenhouse emissions which depend on the combustion and gasification of coal, biomass, or refuse-derived fuel, such as integrated gasification combined cycle processes, are especially affected by these uncertainties. This project seeks to combine experimental measurements and quantum chemical modelling to produce a detailed mechanistic model for the reactions of sulfur in high-temperature systems. Such a model will provide designers with a tool to optimise these complex interacting systems.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100009
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Research Hub for Energy-efficient Separation. The ARC Research Hub for Energy-efficient Separation aims to develop advanced separation materials, innovative products and smart processes to reduce the energy consumption of separation processes. The Research Hub will create a multi-disciplinary training platform, supplying a highly-trained workforce for the advanced manufacturing sector, particularly in separation technology–a growth area in which Australia can lead the world. The advancement ....ARC Research Hub for Energy-efficient Separation. The ARC Research Hub for Energy-efficient Separation aims to develop advanced separation materials, innovative products and smart processes to reduce the energy consumption of separation processes. The Research Hub will create a multi-disciplinary training platform, supplying a highly-trained workforce for the advanced manufacturing sector, particularly in separation technology–a growth area in which Australia can lead the world. The advancement of Australia’s capability as a world-leading technology provider in manufacturing advanced separation materials and equipment will enable Australian industry to become more energy-efficient and cost-competitive in a global economy.Read moreRead less