Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity ....Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity in adult life. We expect to identify levels of IAP that will represent a health risk as well as the factors that may contribute to increased IAP in homes.Read moreRead less
The Biology, Ecology, Pathology and Control of Mycosphaerella Leaf Blights in Australian Eucalypt Plantations. Leaf spot diseases, caused by Mycosphaerella, have become widespread in over 150,000 ha of Eucalyptus globulus (blue gum) plantations in Western Australia, causing severe reduction in canopy area of young trees. This project will research the epidemiology of these diseases by studying the life cycles of the key pathogenic Mycosphaerella species identified in a previous project, modes an ....The Biology, Ecology, Pathology and Control of Mycosphaerella Leaf Blights in Australian Eucalypt Plantations. Leaf spot diseases, caused by Mycosphaerella, have become widespread in over 150,000 ha of Eucalyptus globulus (blue gum) plantations in Western Australia, causing severe reduction in canopy area of young trees. This project will research the epidemiology of these diseases by studying the life cycles of the key pathogenic Mycosphaerella species identified in a previous project, modes and timing of spore dispersal, the infection process, and host specificity. The economic impact of leaf spot diseases will be assessed from large exclusion trials. A predictive integrated management package for Mycosphaerella foliar diseases will be formulated and evaluated to minimising disease impact.Read moreRead less
The cause of basal stem rot in second rotation Eucalyptus globulus plantations. The Eucalyptus globulus plantation industry consists of over 300000 ha in Australia and is worth 1 billion dollars. The industry has expanded rapidly since the mid 1980's and now many crops are in their second rotation. Recently, poor coppice growth in second rotation crops as a result of fungal basal rot or decay, has started to become a significant management problem to the industry. This project will determine th ....The cause of basal stem rot in second rotation Eucalyptus globulus plantations. The Eucalyptus globulus plantation industry consists of over 300000 ha in Australia and is worth 1 billion dollars. The industry has expanded rapidly since the mid 1980's and now many crops are in their second rotation. Recently, poor coppice growth in second rotation crops as a result of fungal basal rot or decay, has started to become a significant management problem to the industry. This project will determine the cause(s) of basal stem rot/decay and develop management strategies to reduce the impact of the problem.Read moreRead less
Pathogenicity of Mycosphaerella on Eucalyptus globulus plantations in Western Australia. Eucalyptus globulus is the main hardwood species grown in plantations in Western Australia. In recent years, the incidence of foliar damage caused by leaf spot fungi in the genus Mycosphaerella has started to become a worrying management problem for the industry. There are approximately 12 Mycosphaerella species associated with Eucalyptus globulus in Western Australia. This project will determine which are t ....Pathogenicity of Mycosphaerella on Eucalyptus globulus plantations in Western Australia. Eucalyptus globulus is the main hardwood species grown in plantations in Western Australia. In recent years, the incidence of foliar damage caused by leaf spot fungi in the genus Mycosphaerella has started to become a worrying management problem for the industry. There are approximately 12 Mycosphaerella species associated with Eucalyptus globulus in Western Australia. This project will determine which are the priority destructive Mycosphaerella species. The information gained will allow researchers to select and breed eucalypts for resistance of target Mycosphaerella species in the future. The project will also develop methods for rapid pathogenicity screening.Read moreRead less
Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will ....Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will significantly enhance our ability to carry out accurate engineering design of critical offshore infrastructure, as well as marine forecasts in such environments. As such, the project will have major scientific, economic and social benefits for Australia.Read moreRead less
How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if ....Using molecular tools to understand and control the transmission of Cryptosporidium. Cryptosporidium is the major public health concern of water utilities as the parasite has a global impact on the health and survival of millions of people and animals worldwide. It is resistant to chlorine and there are no effective drugs against it. Control strategies therefore rely on understanding how it is transmitted. This project will conduct a comprehensive study utilising molecular tools to determine if the Cryptosporidium in humans is the same as that derived from water contamination sources (animals, sewage etc). The outcomes of this project will result in the development of more targeted, cost-effective preventive measures to minimize exposures to infections, accurate risk assessment, and scientific management of the watershed.Read moreRead less
Structure-activity relationships in the development of new bioactive isoflavonoids. This project aims to develop new chemical substances based on the structure of a group of naturally occuring compounds called isoflavones. Biological activity related to chronic inflammatory (eg arthritis) and heart disease will be examined in cells and animal models. This information will be used to design compounds with enhanced activity. The eventual aim is to develop potential therapeutic agents to treat chr ....Structure-activity relationships in the development of new bioactive isoflavonoids. This project aims to develop new chemical substances based on the structure of a group of naturally occuring compounds called isoflavones. Biological activity related to chronic inflammatory (eg arthritis) and heart disease will be examined in cells and animal models. This information will be used to design compounds with enhanced activity. The eventual aim is to develop potential therapeutic agents to treat chronic inflammatory and cardiovascular disease.Read moreRead less