Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Addressing hepatitis C-related discrimination in a post-cure world. This project aims to address the legal and policy dimensions of hepatitis C discrimination. Hepatitis C is a major public health challenge linked to profound discrimination, including in law and policy. Treatments introduced in 2016 improved cure rates; optimism about disease elimination is high, but questions remain about discrimination faced by those who are cured. This interdisciplinary project’s goal is to generate new knowl ....Addressing hepatitis C-related discrimination in a post-cure world. This project aims to address the legal and policy dimensions of hepatitis C discrimination. Hepatitis C is a major public health challenge linked to profound discrimination, including in law and policy. Treatments introduced in 2016 improved cure rates; optimism about disease elimination is high, but questions remain about discrimination faced by those who are cured. This interdisciplinary project’s goal is to generate new knowledge about hepatitis C discrimination in a post-cure context, and identify opportunities for legal and policy reform. Expected outcomes of the project include better legal, social and policy outcomes for Australians cured of hepatitis C, significantly benefiting these individuals directly and society more broadly.Read moreRead less
Nanostructured Ionic-Molecular Hybrid Liquids. This project aims to produce a new class of green, economical, non-toxic, low volatility, designer solvents from mixtures of one or more molecular components, and ionic liquid-inspired salts. By manipulating the intermolecular forces between components of these nanostructured ionic molecular "hybrid liquids" (HLs), we will develop new understanding of how liquid structure arises from the nano- to the colloidal and even micro-scale. HLs will enable ....Nanostructured Ionic-Molecular Hybrid Liquids. This project aims to produce a new class of green, economical, non-toxic, low volatility, designer solvents from mixtures of one or more molecular components, and ionic liquid-inspired salts. By manipulating the intermolecular forces between components of these nanostructured ionic molecular "hybrid liquids" (HLs), we will develop new understanding of how liquid structure arises from the nano- to the colloidal and even micro-scale. HLs will enable the development novel complex fluids, which are liquids containing interacting particles, polymers, and/or surfactants. Lubricants developed from HL based complex fluids will act as a “test-bed” application for the new understanding this project will engender, towards use of HLs in diverse areas.Read moreRead less
Banded iron formations: life, oxygen and ocean chemistry. This project aims to investigate the co-evolution of life and environments during Earth’s first two billion years using iron-rich chemical sediments deposited from global oceans. The project expects to generate knowledge of Earth’s transition into a planet habitable for complex life by combining nanoscale characterisation techniques, with laboratory experiments and theoretical modelling. Expected outcomes include transformative ideas abou ....Banded iron formations: life, oxygen and ocean chemistry. This project aims to investigate the co-evolution of life and environments during Earth’s first two billion years using iron-rich chemical sediments deposited from global oceans. The project expects to generate knowledge of Earth’s transition into a planet habitable for complex life by combining nanoscale characterisation techniques, with laboratory experiments and theoretical modelling. Expected outcomes include transformative ideas about the role of life in iron and phosphorus cycles, the chemistry of the early ocean, ancient biological productivity, the antiquity of oxygenic photosynthesis and the rise of oxygen. The project will also deliver new conceptual models for the formation of the host-rocks for most of the world’s iron resources, improving how we explore for iron in the Earth’s crust. This should provide benefits to understanding geobiology on Earth and other planets.Read moreRead less
Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Lived experiences of treatment for hepatitis C in Australia. This project aims to support uptake of new hepatitis C treatments. With the introduction of new treatments in 2016, the Australian Government adopted the WHO’s goal of eliminating the disease by 2030. While early treatment rates were high, they have since plateaued, with stigma and poor information considered key obstacles. This project will generate new knowledge on treatment decisions and experiences, using a proven qualitative metho ....Lived experiences of treatment for hepatitis C in Australia. This project aims to support uptake of new hepatitis C treatments. With the introduction of new treatments in 2016, the Australian Government adopted the WHO’s goal of eliminating the disease by 2030. While early treatment rates were high, they have since plateaued, with stigma and poor information considered key obstacles. This project will generate new knowledge on treatment decisions and experiences, using a proven qualitative methodology. In doing so, it will produce a website covering personal experiences of treatment, issues in treatment decision-making, and advice on enhancing life on treatment and after. It will tackle hepatitis C-related stigma, and inform and benefit potential treatment users, families and relevant professionals.
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Using genetic Allee effects to manage invasive populations. An invasion can be started with only a small number of individuals, and it is very difficult to reliably detect these individuals. This project aims to develop new genetic technology that can send small founder populations extinct without affecting large populations. This technology removes the problem of having to detect small populations; these small populations will go extinct on their own, without the need for management interventio ....Using genetic Allee effects to manage invasive populations. An invasion can be started with only a small number of individuals, and it is very difficult to reliably detect these individuals. This project aims to develop new genetic technology that can send small founder populations extinct without affecting large populations. This technology removes the problem of having to detect small populations; these small populations will go extinct on their own, without the need for management intervention. This technology could be used to prevent establishment and spread of invasive species and agricultural pests. Through a combination of experimentation and modelling, the project develops this technology and assesses its use in applied problems ranging across environment, agriculture, and health.Read moreRead less
Visual field impairment and injury: A population-based study. This project aims to link a large-scale ophthalmic database of visual field tests to population-based injury data which includes police-reported crash data, hospitalisation, death and trauma data in people aged over 60 years. The identification of individuals with high risk visual fields will enable the development of targeted interventions at the local, national and international level to prevent injuries due to visual field loss. Si ....Visual field impairment and injury: A population-based study. This project aims to link a large-scale ophthalmic database of visual field tests to population-based injury data which includes police-reported crash data, hospitalisation, death and trauma data in people aged over 60 years. The identification of individuals with high risk visual fields will enable the development of targeted interventions at the local, national and international level to prevent injuries due to visual field loss. Significant benefits include a reduction in the number of injuries and consequent reductions in personal harm and health care demands.Read moreRead less
Quantifying vertical and lateral ocean transport due to fronts and eddies. This project aims to quantify the intensity and location of ocean currents at unprecedented fine spatial scales by using data from a new generation of high-resolution satellites. These fine scales dominate the lateral and vertical transport of ocean-borne material, including heat, larvae and pollutants like oil and plastics, yet are poorly understood. New algorithms for processing satellite data will be developed and test ....Quantifying vertical and lateral ocean transport due to fronts and eddies. This project aims to quantify the intensity and location of ocean currents at unprecedented fine spatial scales by using data from a new generation of high-resolution satellites. These fine scales dominate the lateral and vertical transport of ocean-borne material, including heat, larvae and pollutants like oil and plastics, yet are poorly understood. New algorithms for processing satellite data will be developed and tested using in situ data in the significant North West Shelf region. Expected outcomes will be novel methods to identify ocean currents and a paradigm shift in quantification of fine-scale ocean dynamics. This will benefit operational oceanography in the areas of maritime safety, defence, fisheries and the offshore industry.Read moreRead less
Discovering how termites use vibrations to thrive in a predators' world. Our recent research revealed termites use vibrations to avoid predators/competitors for survival. However, the enabling mechanisms of this amazing ability remain unknown. The project aims at unlocking the secrets of these mechanisms by relating the mechanical properties of termite, legs, antennae and sensing organs (measured with advanced micro measurement techniques) to vibration signatures of ants and termites (extracted ....Discovering how termites use vibrations to thrive in a predators' world. Our recent research revealed termites use vibrations to avoid predators/competitors for survival. However, the enabling mechanisms of this amazing ability remain unknown. The project aims at unlocking the secrets of these mechanisms by relating the mechanical properties of termite, legs, antennae and sensing organs (measured with advanced micro measurement techniques) to vibration signatures of ants and termites (extracted using innovative signal processing techniques and nonlinear dynamics). We will develop novel bio-dynamics models that incorporate machine learning. We will test the models’ ability to manipulate termites foraging behaviour, with the ultimate objective of developing chemical-free, vibration-based pest control devices. Read moreRead less