Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992245
Funder
Australian Research Council
Funding Amount
$3,088,350.00
Summary
The Virtual Geological Observatory: a four dimensional view into the Earth through deep-time data-mining. The Fellowship aims to reveal the underlying processes of plate tectonic cycles, paleogeography, sea-level change and the formation of ore deposits and hydrocarbon resources since the explosion of life during the Cambrian period. Using a mantle convection framework, we will discover how the cyclicity in mid-ocean ridge creation and the subduction dynamics associated with the aggregation and ....The Virtual Geological Observatory: a four dimensional view into the Earth through deep-time data-mining. The Fellowship aims to reveal the underlying processes of plate tectonic cycles, paleogeography, sea-level change and the formation of ore deposits and hydrocarbon resources since the explosion of life during the Cambrian period. Using a mantle convection framework, we will discover how the cyclicity in mid-ocean ridge creation and the subduction dynamics associated with the aggregation and dispersal of Gondwana and Pangea has been driving plate tectonic cycles and cyclicity at the Earth's surface. A Virtual Geological Observatory will transform our understanding of this ancient world by fusing geodata-mining and high-performance computer simulation outputs in the plate-tectonic context.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100003
Funder
Australian Research Council
Funding Amount
$1,814,346.00
Summary
New directions, new problems and new data types in statistical science. Statistically challenging problems today involve answering many more questions than we have data. Solving them will elucidate the causes of diseases such as cancer, and provide better security for the community. The project will develop new methods for tackling these challenging problems, taking statistical science in new directions.
Australian Laureate Fellowships - Grant ID: FL0992138
Funder
Australian Research Council
Funding Amount
$3,100,000.00
Summary
Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial ....Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial treatments; contribute to Australia's continued international leading role in drug discovery research; enhance international links and attract industry investment in Australia; and provide a stimulating research training environment to inspire and motivate the next generation of scientists.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100027
Funder
Australian Research Council
Funding Amount
$2,898,150.00
Summary
Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of du ....Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division. By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100199
Funder
Australian Research Council
Funding Amount
$2,529,601.00
Summary
Responding to the challenges of identity change: an advanced social identity approach to issues of leadership, health and well-being. This project develops an integrated framework for understanding how changes to identity that are associated with the changing fabric of the modern world impact on Australians' health and well-being. The project will develop and test strategies for tackling these challenges and minimising their negative consequences.
Australian Laureate Fellowships - Grant ID: FL150100106
Funder
Australian Research Council
Funding Amount
$2,951,945.00
Summary
Bio-metrology and modelling of a complex system: the malaria parasite. Bio-metrology and modelling of a complex system: the malaria parasite: This fellowship project aims to develop a cross-disciplinary program to measure, model and manipulate a complex cellular system — sexual differentiation of the human malaria parasite. Combining life and physical sciences with powerful imaging techniques, the project seeks to develop quantitative biochemical, biophysical and modelling techniques to probe a ....Bio-metrology and modelling of a complex system: the malaria parasite. Bio-metrology and modelling of a complex system: the malaria parasite: This fellowship project aims to develop a cross-disciplinary program to measure, model and manipulate a complex cellular system — sexual differentiation of the human malaria parasite. Combining life and physical sciences with powerful imaging techniques, the project seeks to develop quantitative biochemical, biophysical and modelling techniques to probe a complex system in a way previously not possible. It expects to integrate and correlate thousands of measurements of the dynamic processes inside cells and use these datasets to generate rigorous and sophisticated mathematical models that can predict drivers of commitment for transformation of the parasite to a sexual phase in preparation for transmission to mosquitoes. This holistic approach hopes to deliver new biotechnology and biomedical outcomes, including new ways to combat disease in livestock and humans.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100074
Funder
Australian Research Council
Funding Amount
$2,175,454.00
Summary
Using biological invasions to understand evolutionary processes. The invasion of cane toads through Australia has been devastating for many native species, but created opportunities for others. The rapid evolutionary responses stimulated by toad invasion provide a uniquely powerful model system with which to explore the broader question of how species adapt to novel challenges.
Australian Laureate Fellowships - Grant ID: FL100100066
Funder
Australian Research Council
Funding Amount
$1,523,582.00
Summary
New approaches for pest control and maintaining healthy environments under climate change. Natural environments are rapidly changing due to climate and human population pressure, affecting food supply and natural heritage. Insects and other invertebrates perform essential services like pollination, pest control and soil turnover, and provide food for wildlife. These services are under threat, and ways of maintaining them and protecting biodiversity need to be developed. This project will identif ....New approaches for pest control and maintaining healthy environments under climate change. Natural environments are rapidly changing due to climate and human population pressure, affecting food supply and natural heritage. Insects and other invertebrates perform essential services like pollination, pest control and soil turnover, and provide food for wildlife. These services are under threat, and ways of maintaining them and protecting biodiversity need to be developed. This project will identify the genetic and evolutionary mechanisms that insects use to deal with environmental changes and the processes that promote evolutionary resilience to safeguard environmental services. This should lead to guidelines for sustainable agricultural production and biodiversity protection in threatened environments like the Australian Alps.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL100100183
Funder
Australian Research Council
Funding Amount
$2,168,370.00
Summary
Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virule ....Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virulent strains of human, animal or plant diseases, require such evolutionary thinking. Cutting-edge mathematical tools also prepare Australians for an era in the near future where genomic data are so cheap to acquire that training in complex mathematical and logical analysis becomes a factor limiting scientific progress.Read moreRead less