Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100030
Funder
Australian Research Council
Funding Amount
$3,320,000.00
Summary
A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity wi ....A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity within and between plant families will improve our understanding of resistance gene evolution in wild species and the impact of domestication and breeding on resistance gene diversity. Translation of this knowledge will support breeding for crop resilience, leading to durable resistance and more sustainable crop productionRead moreRead less