Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100022
Funder
Australian Research Council
Funding Amount
$4,787,259.00
Summary
ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop pr ....ARC Research Hub for Sustainable Crop Protection. The Hub aims to develop and commercialise an innovative biological alternative to chemical fungicides targeting economically significant diseases of broadacre and horticultural crops. It addresses industry challenges of fungicide resistance, chemical residues in food, off-target effects and environmental harm. It builds on ground-breaking ‘BioClay’ platform to deliver pathogen targeting RNA using clay particles as non-genetically modified crop protection. An expert multidisciplinary team uniting science, commercial and social licence pathways ensures industry and consumer uptake advancing $60B Australian Agriculture. The Hub translates to increased productivity, market access and enhanced environmental credentials of Australian food.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100017
Funder
Australian Research Council
Funding Amount
$1,231,000.00
Summary
Networked knowledge for repatriation communities. This project aims to build a digital facility that supports the repatriation of Indigenous human remains. Repatriation contributes to reconciliation and Indigenous healing and wellbeing, and has been the most important agent of change in the relationship between Indigenous peoples, museums and the academy over the past 40 years. Successful repatriation requires and produces research materials diverse in type, geography and accessibility. Within a ....Networked knowledge for repatriation communities. This project aims to build a digital facility that supports the repatriation of Indigenous human remains. Repatriation contributes to reconciliation and Indigenous healing and wellbeing, and has been the most important agent of change in the relationship between Indigenous peoples, museums and the academy over the past 40 years. Successful repatriation requires and produces research materials diverse in type, geography and accessibility. Within an Indigenous data-governance framework, this project will gather, preserve and make accessible a critical and extensive record of repatriation information worldwide. The project is expected to support repatriation practice and scholarship and improve the opportunities of repatriation for social good.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668435
Funder
Australian Research Council
Funding Amount
$1,300,000.00
Summary
Biomedical Engineering Sensing and Imaging Facility. The sensing and imaging facility will be the only national facility for leading engineering and medical researchers to undertake multidiscipline research into live and model biological systems. The facility will capture and combine existing strengths in these fields in Melbourne. This will provide new insights into the physiology of human, animal and plant systems and the development of preventive and curative strategies for disease.
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
Human Podocyte Depletion, Glomerular Hypertrophy And Glomerulosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$601,490.00
Summary
Many kidney diseases commence with injury to glomeruli (kidney filters) which leads to glomerular scarring and loss. There is strong evidence from animal studies that a specific glomerular cell type (the podocyte) is central to this process of glomerular injury. In this study, we will analyse the relationships between podocyte depletion and glomerular scarring in human kidneys from 5 racial groups (white and African Americans, white and Aboriginal Australians, Senegalese Africans).
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989226
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Multi-photon imaging for infection, immunity, and self recognition. This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents such as bacteria and viruses within living tissues. This will immensely improve our capacity to understand interactions between the immune system, invading organisms and the rest of our body. The intravital imaging system will provide novel insights into how the immune system works, which will ....Multi-photon imaging for infection, immunity, and self recognition. This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents such as bacteria and viruses within living tissues. This will immensely improve our capacity to understand interactions between the immune system, invading organisms and the rest of our body. The intravital imaging system will provide novel insights into how the immune system works, which will benefit the design of vaccines, the treatment of cancer, and our understanding of allergy. This state-of-the-art facility will also provide vital training in an emerging technology that will have application in many areas of biology.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882889
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imper ....History, the archives and new technologies: developing the Australian women's archives project. This project will create and define generic tools and services to increase the productivity of those involved with the creation, maintenance and use of source material for humanities research. It will provide a pathway to move this infrastructure onto a more sustainable footing and address issues of information overload, authority and quality facing researchers in the networked digital age. This imperative is seen by scholars and representatives of the nation's major collecting institutions as a primary limiting factor in the contemporary research environment. The project will enhance Australia's reputation as a world leader in the development of web-based information infrastructure to support research and scholarship.Read moreRead less
Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less
ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other cou ....ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other countries to develop new technologies for the detection and eradication of parasites. This emphasis will not only protect Australia's borders but will assist our near neighbours and lead to the development of technologies with an economic benefit to Australia.
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