Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989920
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a c ....Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a current unmet need for scientists in this country and will provide cutting-edge technologies to Australian researchers so they can better detect, understand, and treat human, animal and plant diseases and the environmental impact of climate change.Read moreRead less
Studies of the degradation of dyes and pigments in inks on paper, in photographic media, and on painted surfaces. The National collecting institutions (the National Archives of Australia, the National Museum of Australia,Screen Sound Australia, the National Library of Australia, and the Australian War Memorial) have collections important to our national heritage on paper, photographic film and other media which they are required by law to preserve for future generations of Australians. Surveys ....Studies of the degradation of dyes and pigments in inks on paper, in photographic media, and on painted surfaces. The National collecting institutions (the National Archives of Australia, the National Museum of Australia,Screen Sound Australia, the National Library of Australia, and the Australian War Memorial) have collections important to our national heritage on paper, photographic film and other media which they are required by law to preserve for future generations of Australians. Surveys of their collections have shown that a significant proportion of their most important collections is in need of conservation. This project aims at determining ways of conserving these valuable artefacts, and developing strategies for their display and storage.Read moreRead less
Protein degradation in mammals. One mechanism by which the regulation of protein turnover occurs is the balance between the activity of enzymes responsible for the ubiquitination and deubiquitination of target proteins. The majority of targets of this second family of enzymes are unknown. This project proposes a method for the identification of the targets of two specific mammalian deubiquitinating enzymes in order to understand their function and to begin to explore this new research field. ....Protein degradation in mammals. One mechanism by which the regulation of protein turnover occurs is the balance between the activity of enzymes responsible for the ubiquitination and deubiquitination of target proteins. The majority of targets of this second family of enzymes are unknown. This project proposes a method for the identification of the targets of two specific mammalian deubiquitinating enzymes in order to understand their function and to begin to explore this new research field. Knowledge about this new aspect of protein degradation could provide a powerful tool to test the effect of the stabilisation or removal of specific proteins in the cell and also to develop new technologies in protein production.Read moreRead less
Mimetics and small chemical compounds for hemopoietic stem cell mobilisation. This project will result in the design and synthesis of new chemical compounds that could be used clinically to help collect blood stem cells for bone marrow transplantation. For patients this will mean more effective and less painful ways to collect stem cells and better transplant outcomes. There is a large, ongoing international market for this type of drug and likelihood of significant financial benefit.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775482
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Ultratrace element and isotope analysis facility. Analysis of trace concentrations of contaminants in food, water and biota is essential for proper environmental and human health protection, and the ability to analyse different isotopes of nutrients will improve our capability to develop techniques to fortify foods with essential micronutrients. The instrumentation will also assist our understanding of the geological processes, climate and environmental change and the formation and location of m ....Ultratrace element and isotope analysis facility. Analysis of trace concentrations of contaminants in food, water and biota is essential for proper environmental and human health protection, and the ability to analyse different isotopes of nutrients will improve our capability to develop techniques to fortify foods with essential micronutrients. The instrumentation will also assist our understanding of the geological processes, climate and environmental change and the formation and location of mineral deposits having economic potential in Australia. By improving forensic identification techniques, the instrumentation will allow identification and tracking of environmental contamination of the food chain and water supplies, and to identify and track criminal and terrorist activity. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989759
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting a ....Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries and will generate science to support and stimulate domestic industry, enhance the domestic knowledge base and international research profile, train students and future synchrotron scientists and foster domestic and international collaborations.Read moreRead less
Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989541
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
High Field Solid State and Multinuclear NMR Spectrometer for Structure/Function Analysis of Materials. Projects requiring the proposed infrastructure are aligned with two of the National Research Priorities. The research will lead to the development of novel materials, polymers and drugs, in particular nanoporous molecular frameworks, as well as reactive catalysts. The understanding of protein structure, disease and metabolic pathways which will be established using the proposed equipment will c ....High Field Solid State and Multinuclear NMR Spectrometer for Structure/Function Analysis of Materials. Projects requiring the proposed infrastructure are aligned with two of the National Research Priorities. The research will lead to the development of novel materials, polymers and drugs, in particular nanoporous molecular frameworks, as well as reactive catalysts. The understanding of protein structure, disease and metabolic pathways which will be established using the proposed equipment will contribute to the priority area 'Promoting and Maintaining Good Health'. In addition, the new equipment will extend capabilities and postgraduate training in chemistry, nanotechnology, and biomedicine (the priority area of 'Frontier Technologies for Building and Transforming Australian Industries').Read moreRead less