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In Vivo Studies On Ventriculo-vascular Coupling And The Role Of Aortic Pressure Wave Morphology On Coronary Blood Flow
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Heart disease is a leading cause of death and disability in Australia. Conditions resulting in reduced blood flow to the heart are particularly common and dangerous. Despite significant progress, we still do not understand exactly how changes in heart function and the aorta (the major artery arising from the heart) affect blood flow to the heart. This study will utilise sophisticated new techniques to look at the interactions between heart function, pressure in the aorta and coronary blood flow
Physiology Of Acute Coronary Syndromes: Focus On Microvascular Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$90,029.00
Summary
Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved t ....Heart attacks,caused by blocked coronary arteries are an important public health concern.There are patients who have a worse outcome due to damage of small blood vessels that cannot be visualised with normal testing. New blood tests and invasive technology are available that can assess these small vessels.We plan to use these techniques to observe the extent of small blood vessel damage in patients with heart attacks and hope this will lead to better understanding of heart attacks and improved treatments.Read moreRead less
Establishing A Model Of Occlusive Middle Cerebral Artery Stroke In The Sheep
Funder
National Health and Medical Research Council
Funding Amount
$74,365.00
Summary
Stroke is the second leading cause of death and the highest cause of disability in adult Australians, however our lack of an animal model that correctly replicates the human condition has severely hindered our understanding and treatment of the disease. This research project aims to develop a model of stroke in the sheep using a surgical approach that future researchers may use and adapt to further explore the physiology of the disease and trial therapeutic techniques to treat stroke.
Double Blind, Randomised Controlled Trial Assessing The Efficacy Of Endothelin-1 Receptor Antagonism In Preventing Peri-procedural Myonecrosis In Patients With Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
While the focus in the treatment of coronary artery disease has primarily been on the large vessels in the heart, vessels of small calibre may also play a significant role in patients with angina, heart attack, and muscle injury related to a stenting procedure.This project aims elucidate the possible mechanisms which cause dysfunction in these small vessels. I also hope to find a treatment strategy which may benefit patients with small vessel problems and thus improve their overall outcome.
Validation Of Point Of CarE CT DeRived FracTionAl Flow Reserve In Stable Coronary Artery Disease (VERITAS)
Funder
National Health and Medical Research Council
Funding Amount
$78,554.00
Summary
In stable coronary artery disease outcomes are dependent on the presence and burden of ischaemia. Current methods of assessing ischaemia are either invasive with associated risks or non-invasive but limited in their diagnostic accuracy. Our research plans to assess the real world feasibility of a novel, non-invasive, point of care CT-Derived Fractional Flow Reserve technique and its potential for guiding clinical decision making and influencing downstream testing.
Non-Inasive Wave Intensity Analysis In Paediatric Congenital Heart Disease: A Novel Application Of Cardiac Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$136,861.00
Summary
Alterations in heart pumping function, or blood vessel structure, can limit the supply of blood and oxygen to the body. Wave Intensity Analysis (WIA) is a new way of characterising these interactions with great precision. Up until now, WIA has been performed in adult and animal studies using mainly invasive techniques. This project will develop a non-invasive method for WIA using cardiac Magnetic Resonance Imaging, to gain new insights into congenital heart disease in children.
Microvascular Function And Outcome In Patients With Acute Coronary Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$79,514.00
Summary
Damage to the small vessels of the heart is a hallmark of heart attacks. Furthermore, small vessel dysfunction (MVD) is associated with a worse prognosis even in the presence of an unblocked major coronary artery following a heart attack. Using novel invasive assessments, we aim to analyse the prevalence and clinical predictors of MVD, assess the impact of MVD on short and long-term outcome after heart attack and address the impact of new treatments on MVD and heart muscle recovery.
Cardiac Matrix Modulation By Platelet Derived Growth Factor To Improve Outcomes After Myocardial Infarction
Funder
National Health and Medical Research Council
Funding Amount
$96,009.00
Summary
This project is directed towards improving the poor outcome in patients suffering heart failure. Whilst rates of some cardiovascular diseases are decreasing, heart failure incidence is rising significantly. Once end stage heart failure occurs, heart transplantation is possible but has several limitations including organ availability. This research into cardiac regeneration could potentially lead to a significant therapy for heart failure, thereby translating into life-saving outcomes.
Effects Of A Novel Hotspot Mutation Of Brm In Non-Melanoma Skin Cancer Development
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transfo ....Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transformation to malignancy.Read moreRead less
Characterisation Of Autoreactive T Cells In Chronic Idiopathic Urticaria Would Improve Its Diagnosis And Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$97,182.00
Summary
Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU ....Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU.Read moreRead less