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Developing The Epidemiological Evidence Base For Eczema Prevention
Funder
National Health and Medical Research Council
Funding Amount
$476,728.00
Summary
Eczema, food allergy, asthma and hay-fever are all common conditions that are a substantial burden for individuals and families. To prevent them, we need to know their causes, but these are not yet well understood. We need better studies to identify what is causing our children to develop these allergic diseases, and rigorous studies to prevent them. In this fellowship, I will explore the causes and consequences of these conditions and test ways to prevent children from developing them.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
New Insights Into The Mechanisms Of Thrombogenesis In Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disturbance (arrhythmia), which is associated with a high risk of stroke due to clot formation within the left atria. At present we still only have a limited understanding of the mechanism of clot formation in AF. The aim of this study is to determine the critical mechanisms that contribute to clot formation within the left atria in AF. This knowledge is fundamental to the development of more successful interventional approaches.
Wounds, burns and scalds are frequent injuries which can lead to deformity, disfigurement and loss of movement. We have shown that the cytoskeletal protein, Flightless I (FliI), is an important regulator of wound repair. We plan to further investigate FliI in wound and burn injuries using new cell-specific transgenic animal models and to develop a new FliI-antibody based therapy to treat wound and burn injuries.
Practice- And Policy-relevant Research In Skin Cancer Epidemiology, Prevention And Screening
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
This Fellowship will enable me to lead an internationally-competitive program of research in skin cancer epidemiology, prevention & screening that will lead to improved patient and population health through impacts on clinical practice and health policy. My aim is to lead paradigm-shifting contributions in: ? Genetic epidemiology of melanoma, ? Precision skin cancer prevention & screening, and ? Public health genomics for cancer prevention.
Stem And Progenitor Cell Contribution To Skin Wounds And Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Skin wounds represent a major health and economic burden. Although skin stem cells have been used routinely for the treatment of wounds, they cannot reconstitute a fully functional skin given the complexity and the many cell types usually involved in wound healing. In this project, we intend to evaluate the role of different cell populations on modulating skin wound healing to produce more regeneration and less scaring.
Modulating Skin Regenerative Responses To Improve Wound Repair And Fight Carcinogenesis
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Skin disorders, such as hard to heal wounds or the most common skin cancers, are a major burden on the national health system. Despite their different nature they employ similar mechanisms of response to injury. In this project we intend to develop a comprehensive understanding of the genetic and molecular mechanisms at play to allow clinical interventions to prevent or to cure these disorders.
Integrating Behaviour Change And Technology Uptake Models Into Skin Cancer Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$459,271.00
Summary
Two in three Australians will develop skin cancer in their lifetime, and skin cancer incidence is expected to increase. Therefore optimal ways to prevent and early detect skin cancers are of utmost importance to Australia’s public. By integrating the latest behaviour change models and technology uptake models to develop innovative interventions, this fellowship aims to ascertain that all Australians regardless of their location have access to optimal skin cancer prevention and early detection ca ....Two in three Australians will develop skin cancer in their lifetime, and skin cancer incidence is expected to increase. Therefore optimal ways to prevent and early detect skin cancers are of utmost importance to Australia’s public. By integrating the latest behaviour change models and technology uptake models to develop innovative interventions, this fellowship aims to ascertain that all Australians regardless of their location have access to optimal skin cancer prevention and early detection care.Read moreRead less
Addressing Important Evidence Gaps In The Management Of Severe Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$256,839.00
Summary
There are currently large gaps in the evidence base for management of common severe bacterial infections. My research plan focuses on the most common of these: Staphylococcus aureus infections, bone and joint infections, skin infections, and severe sepsis. In order to both generate important evidence to inform practice, as well as to develop my own skills and experience as an expert in clinical trials, I have initiated randomised controlled trials in each of these areas.