New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. ....New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. Therefore many Australians will suffer from the combined impact of the AIDS illness itself, opportunistic infections, the side-effects of treatment and natural aging. We aim to develop new drugs to combat this disease to help people everywhere lead happier, healthier and more productive lives.Read moreRead less
Sensing atmosphere: Understanding the HNOX-protein gas-sensing capability and how it is affected by heme-oxidation. The project investigates how gas sensing heme-proteins from the novel HNOX (Heme-Nitric Oxide) family are able to discriminate between different gaseous ligands such as O2 and NO and how oxidation of the heme alters this response. The gas-sensing capability of the HNOX proteins is crucial for organisms ranging from bacteria to humans. Thus, understanding of these signalling mechani ....Sensing atmosphere: Understanding the HNOX-protein gas-sensing capability and how it is affected by heme-oxidation. The project investigates how gas sensing heme-proteins from the novel HNOX (Heme-Nitric Oxide) family are able to discriminate between different gaseous ligands such as O2 and NO and how oxidation of the heme alters this response. The gas-sensing capability of the HNOX proteins is crucial for organisms ranging from bacteria to humans. Thus, understanding of these signalling mechanisms will have a strong impact on many scientific fields from the control of pathogen growth to human blood pressure regulation. This collaboration will establish Australian scientists and as world-leading in the field of NO and redox signalling. This development will also be of substantial benefit for the training of the next generation of Australian students and scientists.Read moreRead less
A unified approach to studies on mitochondrial biogenesis. Mitochondria supply the cell with the majority of its energy as well as performing other key functions. How mitochondrial processes are regulated within the cell is an important area of biology. The broad aims of this collaboration are to analyse processes involved in mitochondrial biogenesis using yeast and mammalian cells as model systems. In particular the protein import processes and mitochondrial stress responses will be studied. Th ....A unified approach to studies on mitochondrial biogenesis. Mitochondria supply the cell with the majority of its energy as well as performing other key functions. How mitochondrial processes are regulated within the cell is an important area of biology. The broad aims of this collaboration are to analyse processes involved in mitochondrial biogenesis using yeast and mammalian cells as model systems. In particular the protein import processes and mitochondrial stress responses will be studied. The outcomes of this work will enable us to gain an appreciation of the similarities and differences in processes that exist between organisms so that general, unifying models can be made.Read moreRead less
Structure and function of novel transporters in alphaproteobacteria. First, detailed knowledge of a set of membrane transporters and the way their activity might be inhibited, will have implications for the treatment of human disease. Second, excellent outcomes are provided for the training of postgraduate students and research staff. This project entails cutting edge technology, and the transfer of technical capabilities not currently available in Australia. Third, our studies on non-pathogenic ....Structure and function of novel transporters in alphaproteobacteria. First, detailed knowledge of a set of membrane transporters and the way their activity might be inhibited, will have implications for the treatment of human disease. Second, excellent outcomes are provided for the training of postgraduate students and research staff. This project entails cutting edge technology, and the transfer of technical capabilities not currently available in Australia. Third, our studies on non-pathogenic species of alpha-proteobacteria provides for a timely advance in our knowledge of their biology: other species of alpha-proteobacteria were amongst the first organisms trialled for biological weapons by the USA and the former Soviet Union, and those pathogenic species are rated as Class 3 organisms.Read moreRead less
Role of autophagy in degradation of endoplasmic reticulum (ER)-localised protein aggregates. This study will provide a new understanding of protein aggregate accumulation in the endoplasmic reticulum (ER), a phenomenon that occurs in aging cells and protein conformational diseases, and under stress conditions and during secretory protein overexpression. This information will inform strategies to prevent the onset of protein conformational diseases and help identify targets for pharmaceutical int ....Role of autophagy in degradation of endoplasmic reticulum (ER)-localised protein aggregates. This study will provide a new understanding of protein aggregate accumulation in the endoplasmic reticulum (ER), a phenomenon that occurs in aging cells and protein conformational diseases, and under stress conditions and during secretory protein overexpression. This information will inform strategies to prevent the onset of protein conformational diseases and help identify targets for pharmaceutical intervention. In addition, a powerful model system for studies of ER protein aggregation will be established, high-level training in biochemistry and morphometry will be provided, and an international collaboration of the highest calibre will be initiated.Read moreRead less
Development of the applications of signal processing to mechanical problems and machine diagnostics. It is intended to extend research collaboration in the following areas of interest to both UTC and UNSW:
(1) Dynamics of gears for diagnostics and noise control
(2) Application of blind source separation techniques to mechanical problems
(3) Application of cyclostationary signal analysis techniques to machine diagnostics
(4) Determination of structural dynamic properties from response measure ....Development of the applications of signal processing to mechanical problems and machine diagnostics. It is intended to extend research collaboration in the following areas of interest to both UTC and UNSW:
(1) Dynamics of gears for diagnostics and noise control
(2) Application of blind source separation techniques to mechanical problems
(3) Application of cyclostationary signal analysis techniques to machine diagnostics
(4) Determination of structural dynamic properties from response measurements
(5) Diagnostics of diesel engines and other reciprocating machines.
This project will result in the publication of joint papers in each of these topics, and give material to form the basis of an application for at least one FAIR project in the area of gear noise control and diagnostics.Read moreRead less
CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and process ....CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and processing these CHAMP data.
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Computational methods for precise reconstruction of white-matter fibre tracts in the human brain using diffusion tensor imaging. One in five Australians will experience a mental illness. This project will facilitate a new method for: (1) brain researchers to advance the fundamental understanding of mental illnesses and brain disorders; (2) medical clinicians to diagnose and assess the growing incidence of mental illness confronting Australia's ageing population, thereby addressing the ageing wel ....Computational methods for precise reconstruction of white-matter fibre tracts in the human brain using diffusion tensor imaging. One in five Australians will experience a mental illness. This project will facilitate a new method for: (1) brain researchers to advance the fundamental understanding of mental illnesses and brain disorders; (2) medical clinicians to diagnose and assess the growing incidence of mental illness confronting Australia's ageing population, thereby addressing the ageing well and ageing productively national research priority; and, (3) neurosurgeons to guide surgery via localisation of major neural tracts. In addition to contributing to the understanding, diagnosis and treatment of Australia's endemic mental health burden, this project will advance Australia's skill-base and international standing in basic scientific research.Read moreRead less
Robust Beamforming for Radar Imaging. The impact of radar imaging technologies on security and search and rescue operations is indisputable. They play a vital role in safeguarding a country from terrorism and crime, protecting its borders, and predicting adverse weather patterns. Searching for survivors in disaster areas such as earthquakes and fires can greatly benefit from the proposed research. Law-enforcement officers can employ radar imaging technology to enable accurate determination of t ....Robust Beamforming for Radar Imaging. The impact of radar imaging technologies on security and search and rescue operations is indisputable. They play a vital role in safeguarding a country from terrorism and crime, protecting its borders, and predicting adverse weather patterns. Searching for survivors in disaster areas such as earthquakes and fires can greatly benefit from the proposed research. Law-enforcement officers can employ radar imaging technology to enable accurate determination of targets of interest, obstacles, weapons, victims, outlaws, and hostages inside enclosed structures or buildings. The proposed research and its findings will support the development of cutting edge radar imaging research and technology in Australia.Read moreRead less