Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100079
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered o ....A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered ocean where waves and ice interact, causing ice-breaking and wave attenuation. This unique facility will enable experiments in sea-ice-wave interactions in a controlled environment. Water and air temperature, thermal stratification, water waveform and ice properties will be adjusted in order to preserve key characteristics of the complex ocean environment.Read moreRead less
Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits a ....Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits also include the development of new cutting-edge methodologies for the investigation of Australian desert landscapes, comprehensive baseline data of how this region has evolved prior to European colonization and resolving why no Pleistocene aged archaeological sites have been found in the region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100220
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Sonic drilling to provide contamination-free core sampling of rock and unconsolidated sediment. Australia is the world's driest inhabited continent. Understanding environmental and climatic changes, from the temperate period when humans arrived about 50,000 years ago to the present state of widespread aridity, is crucial for modelling future climate change. This facility will provide new generation drilling equipment which is necessary to obtain accurate records.
Palaeoclimate reconstructions from the isotopic signatures of fossilised leaf waxes. This project develops a method for using the chemical signature of fossilised leaf waxes to reconstruct hydrologic change in south-eastern Australia during the Holocene (last 10,000 years) and Eocene (56-34 million years ago). Understanding climate in the geologic past is essential for testing models and projecting future climate with rising carbon dioxide.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less
A 140,000 year insight into the imprint of climate and humans on Australia. Before the arrival of Europeans, two events shaped Australia's current landscapes and biota more than any others: climate change during the glacial cycle and the arrival of humans on the continent. However, the full scale of these events is not well understood. High resolution analyses of two continuous 140 000 year old sediment deposits will be used in this project to fill this void and answer fundamental questions abou ....A 140,000 year insight into the imprint of climate and humans on Australia. Before the arrival of Europeans, two events shaped Australia's current landscapes and biota more than any others: climate change during the glacial cycle and the arrival of humans on the continent. However, the full scale of these events is not well understood. High resolution analyses of two continuous 140 000 year old sediment deposits will be used in this project to fill this void and answer fundamental questions about how current Australian environments came to be.Read moreRead less
Estimating the impact of fiscal stimulus on household expenditure. The tax bonus payments of the $42 billion Nation Building and Jobs Plan were among the largest fiscal policy packages in the developed world. This project applies a new methodology to estimate the short-term impact of this cash handout on consumer spending, allowing better modelling of the Australian economy.
International comparisons of retirement decisions and well-being of mature age populations: applied micro-economic analyses. Australia needs a pension reform to promote longer working lives of mature people in a health- and productivity-enhancing way, that is also financially sustainable. This study uses cutting-edge methodology and data to analyse decisions surrounding how mature people disengage from employment towards their eventual permanent retirement, and how these decisions relate to thei ....International comparisons of retirement decisions and well-being of mature age populations: applied micro-economic analyses. Australia needs a pension reform to promote longer working lives of mature people in a health- and productivity-enhancing way, that is also financially sustainable. This study uses cutting-edge methodology and data to analyse decisions surrounding how mature people disengage from employment towards their eventual permanent retirement, and how these decisions relate to their health and well-being. It compares and contrasts Australia with the UK, Germany and the US to derive lessons for developing evidence-based pension reform. International comparative research enables the identification of important policy, institutional and/or cultural differences and lessons that may well be missed by single country studies.Read moreRead less