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Identifying Genetic Risk Factors And Elucidating The Underlying Mechanism(s) Of Parkinsons Disease
Funder
National Health and Medical Research Council
Funding Amount
$85,855.00
Summary
Parkinson’s disease (PD) is a common neurodegenerative disorder affecting 1% of people over 65. This innovative research seeks to discover new genetic risk factors that affect disease development. This provides the capability for genetic screening to identify individuals at risk for PD so preventative measures can be employed at an earlier stage. This information will also provide insights as to how the disease occurs and suggest drug targets to improve current partially effective therapy.
Immune Privilege Of The Hair Follicle: Implications For Alopecia Areata
Funder
National Health and Medical Research Council
Summary
The skin, the second largest organ in the body after the skeleton, is of primary importance to the survival of mammalian life. Hair follicles are complex skin appendages, problems of which have an impact on human health and emotional welfare disproportionate to their small dimensions. In this study we will investigate the role of the immune system in the hair loss disease, alopecia areata, one of the most common human autoimmune diseases with the aim of finding more effective avenues of treatmen ....The skin, the second largest organ in the body after the skeleton, is of primary importance to the survival of mammalian life. Hair follicles are complex skin appendages, problems of which have an impact on human health and emotional welfare disproportionate to their small dimensions. In this study we will investigate the role of the immune system in the hair loss disease, alopecia areata, one of the most common human autoimmune diseases with the aim of finding more effective avenues of treatment for this poorly understood disease.Read moreRead less
The Characterisation Of The Mechanism Of Beta Amyloid Toxicity In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$94,430.00
Summary
Alzheimer�s disease (AD) is the most common form of dementia and is characterised by the beta amyloid peptide (A_) found in plaques in the brain. A structural transition to aggregated/ oligomeric forms of A_ is accompanied by a gain of toxicity. In this study the biological and biophysical characterisation of a variety of A_ peptides will be performed. The study will also use oligomers from cell culture media and brain tissue that have been influential in AD research but poorly characterised.
Structural Characterisation Of Peptide Bound HLA-DQ2, HLA-DQ8, And Their Specific T Cell Receptors In Celiac Disease
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Celiac disease is an inflammatory condition resulting from an inappropriate immune response to dietary gluten, present in cereals such as wheat, rye and barley. In affected individuals, ingestion of gluten can result in bloating, chronic diarrhoea, and malabsorption. At present, the only treatment is strict adherence to a gluten free diet. This project will investigate the immune response to gluten on a molecular level, aiding in the development of new treatments(e.g. non-toxic wheat varieties).
An estimated 5 million patients worldwide suffer from the autoimmune disease and in Australia and New zealand, autoimmune diseases affect around 1 in 20 people.Our research will investigate patients samples and animal models to identify the pathogenesis of autoimmune disease and establish new monitor systems and better therapeutic treatments of autoimmune diseases.