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Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
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Using ancient DNA to understand Australia's past and manage its future. The aim of this program is to establish an ancient DNA research centre for Australia, and use long-term natural records to investigate the genetic responses of animals, plants, and micro-organisms to environmental change. By examining biological processes before, during, and after major changes (eg coral bleaching, salination) the evolution and selective pressures at important genetic loci will be identified, and related to ....Using ancient DNA to understand Australia's past and manage its future. The aim of this program is to establish an ancient DNA research centre for Australia, and use long-term natural records to investigate the genetic responses of animals, plants, and micro-organisms to environmental change. By examining biological processes before, during, and after major changes (eg coral bleaching, salination) the evolution and selective pressures at important genetic loci will be identified, and related to environmental change to enhance effected planning and future management of Australia's ecosystems, biodiversity and tourism. Key records will come from lake-beds, billabongs, coral reefs, rodent nests, megafaunal bones, and ancient human material.Read moreRead less
Drug targets in malaria parasites. Malaria is rampant throughout our Region and hinders the economies of our neighbours reducing regional prosperity and stability. Australian security and aid personnel deployed in the Region contract malaria infections and global warming could bring malaria-carrying mosquitoes south to Sydney. Australia is pre-eminent in malaria research, making lead discoveries in vaccine and drug development. However, we lack crucial resources to study the parasite in the mo ....Drug targets in malaria parasites. Malaria is rampant throughout our Region and hinders the economies of our neighbours reducing regional prosperity and stability. Australian security and aid personnel deployed in the Region contract malaria infections and global warming could bring malaria-carrying mosquitoes south to Sydney. Australia is pre-eminent in malaria research, making lead discoveries in vaccine and drug development. However, we lack crucial resources to study the parasite in the mosquito phase of its life cycle. The Federation Fellowship will create a malaria mosquito facility to redress this crucial gap in our capability. The Fellowship will double as foreign aid investment by enhancing our capacity to protect ourselves as well as supporting our neighbours.Read moreRead less
Molecular machines that drive microbial pathogens. We will provide a comprehensive understanding of molecular machines situated at the surface of bacteria. This ground-breaking research will provide excellent outcomes in the training of research students and staff: this project entails frontier technology, and the transfer of technological capabilities not currently available in Australia. Our study on a non-pathogenic species of bacteria is timely too for National security: related species of b ....Molecular machines that drive microbial pathogens. We will provide a comprehensive understanding of molecular machines situated at the surface of bacteria. This ground-breaking research will provide excellent outcomes in the training of research students and staff: this project entails frontier technology, and the transfer of technological capabilities not currently available in Australia. Our study on a non-pathogenic species of bacteria is timely too for National security: related species of bacteria were amongst the first organisms trialed as biological weapons, and the pathogenic species remain rated as Class 3 organisms by the Centers for Disease Control.Read moreRead less
Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new ....Integrative behaviour: a new synthesis. The research will use a uniquely integrative behavioural approach to a) analyse swarming in locusts, and b) apply powerful new models in nutrition to address key problems in biology, agriculture and human health. Outcomes will include i) an understanding of the molecular and environmental mechanisms controlling swarming in locusts, providing new management and control strategies; ii) insights into human obesity, with health policy recommendations; iii) new technologies for designing nutritional regimes for animal production; iv) an understanding of the responses of insect pests to changing environments; and v) insights into the flow of nutrients across trophic levels within terrestrial ecosystems.Read moreRead less
An investigation into Infection, Immunity & Rational Drug Design. The human population is constantly under threat of microbial attack. The survival of our species reflects a delicate balance between infection and immunity. Whether an individual mounts an effective immune response or succumbs to microbial infection is critically dependent on host proteins interacting effectively with microbial antigens, versus microbes developing sophisticated strategies of invasion and immune evasion. This pr ....An investigation into Infection, Immunity & Rational Drug Design. The human population is constantly under threat of microbial attack. The survival of our species reflects a delicate balance between infection and immunity. Whether an individual mounts an effective immune response or succumbs to microbial infection is critically dependent on host proteins interacting effectively with microbial antigens, versus microbes developing sophisticated strategies of invasion and immune evasion. This proposal will provide fundamental advancement of knowledge in the areas of infection and immunity. The information gleaned from this research will lead to the rational development of therapeutics. Consequently, the research will potentially have an enormous global impact in the area of biomedical health.Read moreRead less
In vivo imaging of the immune system in self tolerance and infectious disease. This proposal will introduce sophisticated imaging technology into our cutting-edge research program. Our approach will permit high resolution imaging of the immune response within an intact animal; currently not possible in Australia at the present time. The unique combination of technology and biological resources will significantly advance knowledge in key areas of basic immunology research. It will provide local ....In vivo imaging of the immune system in self tolerance and infectious disease. This proposal will introduce sophisticated imaging technology into our cutting-edge research program. Our approach will permit high resolution imaging of the immune response within an intact animal; currently not possible in Australia at the present time. The unique combination of technology and biological resources will significantly advance knowledge in key areas of basic immunology research. It will provide local researchers insights into how the body responds to infectious disease and immune-related disorders and be directly applicable to vaccine design. The facility and related research program will undoubtedly attract a team of top-level national and international scientists and students keen to work with this advanced technology.Read moreRead less
Constructing The Building Blocks For Future Nanomaterial Design: Self-assembly and Information Storage in Synthetic Macromolecules. The Federation Fellowship will be used to build a research team with the expertise and the capabililty to assemble the building-blocks required for future applications in nanomateral design. This will be of benefit both to the general Australian research community in the development of new materials and also to support the creation of a vibrant high-tech industry u ....Constructing The Building Blocks For Future Nanomaterial Design: Self-assembly and Information Storage in Synthetic Macromolecules. The Federation Fellowship will be used to build a research team with the expertise and the capabililty to assemble the building-blocks required for future applications in nanomateral design. This will be of benefit both to the general Australian research community in the development of new materials and also to support the creation of a vibrant high-tech industry utilising synthetic materials for applications such as responsive membranes and 'clever' drug deliveryRead moreRead less
Constructing an embryo. This project investigates the cellular and molecular mechanisms underlying temporal and spatial organisation in the eutherian preimplantation embryo. It will examine: the relative roles of cell cycle and circadian clocks in developmental timing; the molecular mechanism by which intercellular adhesion patterns influence spatial organisation; the extent to which marsupials use similar timing and spatial localisation mechanisms to eutherians; the impact of in-vitro manipulat ....Constructing an embryo. This project investigates the cellular and molecular mechanisms underlying temporal and spatial organisation in the eutherian preimplantation embryo. It will examine: the relative roles of cell cycle and circadian clocks in developmental timing; the molecular mechanism by which intercellular adhesion patterns influence spatial organisation; the extent to which marsupials use similar timing and spatial localisation mechanisms to eutherians; the impact of in-vitro manipulations over the first 5 days of mouse pregnancy on embryonic temporal and spatial organisation.Read moreRead less
New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new ....New approaches to functional and structural genomics. Genome sequencing has revealed complete sets of macromolecules that make up our cells. We now need to learn how these macromolecules work together in a coordinated fashion. The proposed research will lead to the discovery of new biological molecules, interactions and processes essential for the function of cells, identify new therapeutic targets and strategies to combat disease, identify new concepts in bio- and nanotechnology, and train new interdisciplinary researchers. It will underpin the National Research Priorities (Frontier Technologies for Building and Transforming Australian Industries, and Promoting and Maintaining Good Health) and help Australia capitalise on a plethora of opportunities for future economic and health benefits.Read moreRead less
Optical Semiconductors for next-generation lasers, optical processors, and integrated optical chips. We are on the verge of an optical processing revolution. The silicon industry evolved from valves to transistors and finally to processors - Optical processing is the next step in the evolution of lasers from gas to solid state, and ultimately to integrated optical chips. Australia had a significant lead in semiconductors during the 1970?s, but unfortunately lost this lead due to a lack of local ....Optical Semiconductors for next-generation lasers, optical processors, and integrated optical chips. We are on the verge of an optical processing revolution. The silicon industry evolved from valves to transistors and finally to processors - Optical processing is the next step in the evolution of lasers from gas to solid state, and ultimately to integrated optical chips. Australia had a significant lead in semiconductors during the 1970?s, but unfortunately lost this lead due to a lack of local market. The emergence of biotechnology and telecommunications offer strong local markets for this new integrated optical technology. This project aims to create a world-leading Research capability in Australia to drive the evolution of integrated optoelectronics, and provide a commercial path to create a leading Australian industry.Read moreRead less