Stress-induced Genomic Instability As A Driver Of Adaptive Responses In Human Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$690,426.00
Summary
Growing experimental evidence suggests human cancer cells use evolutionary conserved programs to regulate their mutation rates in response to pharmacological agents, accelerating adaptation and the emergence of resistance. The purpose of our study is to identify the common molecular pathways and genetic mechanisms driving the regulation of mutation rates. Targeting of these pathways using a new generation of “anti-evolution” drugs is an attractive possibility for novel therapeutic approaches.
Cerebral Palsy (CP) is a devastating, common developmental brain disorder once assumed to be due to lack of oxygen at birth. Using our unique Biobank with DNA and clinical data from families with a CP child, we are examining the genetic origins of CP and how genes and risk factors in pregnancy contribute. We will use computer modelling and testing in animals and brain cells, to understand causes of CP and devise predictive, preventative and therapeutic strategies.
How Do Cross-reactive Memory B Cells Affect Influenza Vaccine Titers?
Funder
National Health and Medical Research Council
Funding Amount
$798,049.00
Summary
Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.
Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to re ....Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to redress that problem by producing a precise calibration of the global changes by analysis of the rock records in Australia, Canada and South Africa. It will provide a much needed time framework within which long-term feedback between atmospheric composition and climate can be understood.Read moreRead less
Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how th ....Murray Basin: A unique archive of late Neogene global change. Salinization, soil erosion, groundwater depletion and surface water degradation are but a few of the inter-related environmental problems facing the Murray-Darling Basin. These problems require an understanding of the way in which shallow groundwater, salts and surface water interact with near-surface sediments. This project is aimed at a better understanding the nature of those near-surface sediments in the Murray Basin and how they were formed. If we can understand how the basin came to be the way it is (in the modern setting), we may better understand the way it might behave when subject to man-made changes like increased groundwater usage, etc.Read moreRead less
A Comprehensive Analysis Of The Role Of The Alcohol Dehydrogenase Gene Cluster In Alcohol-related Disorders And Esophageal Cancer Through Deep Resequencing
Funder
National Health and Medical Research Council
Funding Amount
$605,323.00
Summary
Excessive alcohol consumption remains a major public health concern in Australia where the burden of mental health disorders is dominated by substance-use disorders. Alcohol dehydrogenases (ADHs) are essential in the breakdown of alcohol in the body and we seek to resequence seven ADH genes with the aim to comprehensively catalogue and identify sequence variants that contribute to risk for consuming excessive quantities of alcohol, alcoholism and esophageal squamous cell carcinoma.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major i ....PAST EAST ANTARCTIC ICE SHEET AND GLOBAL SEA-LEVEL VARIATIONS. Unique fossil-bearing, open marine sediments occur inland from the modern Antarctic coastline. These were deposited when a now-glaciated Antarctic basin became a marine embayment, during intervals of significantly reduced ice sheet volume and elevated global sea-level in the past. Urgent palaeontological, sedimentological and geochemical research on these sediments are vital to provide: directly datable in situ evidence for major ice sheet retreat and global sea-level rise in the past; and quantifiable data concerning the environment during such events; an innovative opportunity to improve predictions of Antarctica's response to global warming and answer international debate about past Antarctic Ice Sheet stability.Read moreRead less
Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the E ....Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the Exmouth Sub-basin during the Latest Jurassic. In particular, this project provides an opportunity to explore the role of tectonism in canyon formation, the results of which will be of international interest. Geological models developed in this project will enhance our understanding of deep marine systems.Read moreRead less
Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead ....Southern gateways - the icehouse cometh: Eocene to Oligocene evolution of southeast Australia. The 50 to 30 million years old strata of southeastern Australia have great economic importance for Australia. Most of the gas and oil extracted in the region comes from strata of this age. The research will lead to better age constraints on these reserves, thus enhancing petroleum prospectivity in the area. The global environment changes from 50 to 30 million years charted in this project will lead to a better understanding of the geological record of greenhouse-icehouse change. Knowledge of the nature of this change in the past is critical to predicting how our climate is going to behave in the future.Read moreRead less