Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to re ....Precise global time scale for the oxidation of Earth's atmosphere between 2.6 and 2.0 billion years ago. The rock record from 2600 to 2000 million years ago preserves evidence for dramatically fluctuating greenhouse and icehouse climates at the same time as, and possibly caused by, change from an oxygen-deficient to an oxygen-rich atmosphere. Although the global changes are well-documented, correlation of their timing and duration between continents is poorly constrained. This project aims to redress that problem by producing a precise calibration of the global changes by analysis of the rock records in Australia, Canada and South Africa. It will provide a much needed time framework within which long-term feedback between atmospheric composition and climate can be understood.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100030
Funder
Australian Research Council
Funding Amount
$3,320,000.00
Summary
A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity wi ....A walk on the wild side: understanding disease resistance across plants. Plants are in constant battle with pests and pathogens. Wild species host genetic diversity, providing sources of disease resistance, while the narrow genetic base of crop varieties leads to an increasing reliance on the unsustainable application of chemical fungicides. Here I will apply the latest genomics approaches to characterise disease resistance gene diversity across the plant kingdom. Comparison of gene diversity within and between plant families will improve our understanding of resistance gene evolution in wild species and the impact of domestication and breeding on resistance gene diversity. Translation of this knowledge will support breeding for crop resilience, leading to durable resistance and more sustainable crop productionRead moreRead less
Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the E ....Latest Jurassic history of the Exmouth Sub-basin, North West Shelf: lowstand deposits of the basal Barrow Group. Sand-filled canyons may be excellent petroleum reservoirs, however, interpretation of formation and sediment filling of these major deep marine features is controversial. This project seeks to elucidate the origin of canyons and associated basin floor fans by combining sedimentological data with seismic interpretation and modelling to generate new insights into the history of the Exmouth Sub-basin during the Latest Jurassic. In particular, this project provides an opportunity to explore the role of tectonism in canyon formation, the results of which will be of international interest. Geological models developed in this project will enhance our understanding of deep marine systems.Read moreRead less
Investigating a novel genetic strategy for insect resistance in crops. Plants are in a constant battle with insect pests and there is an increasing reliance on chemical inputs for control. However there are incoming bans on some pesticides, and new approaches are required for pest management. The aim of this project is to develop a new strategy which exploits the dependence of herbivorous insects on phytosterols. Here, we will apply the latest genomics technologies in plants to produce non-utili ....Investigating a novel genetic strategy for insect resistance in crops. Plants are in a constant battle with insect pests and there is an increasing reliance on chemical inputs for control. However there are incoming bans on some pesticides, and new approaches are required for pest management. The aim of this project is to develop a new strategy which exploits the dependence of herbivorous insects on phytosterols. Here, we will apply the latest genomics technologies in plants to produce non-utilizable sterols which will not support insect growth and reproduction, but will still allow the plant to function normally. We will demonstrate this in the important crop canola. Translation of this knowledge will support breeding for crop resilience, leading to durable resistance and more sustainable crop production.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
Reconstruction of marine ecosystems following the greatest mass extinction during the Phanerozoic history of Earth life: Lessons for the present. Frequent defaunation events strongly threaten sustainable development of marine resources and human environments especially in countries that are surrounded by oceans such as Australia. By analysing recovery mechanisms of marine ecosystems following the Permian-Triassic mass extinction, the greatest crisis of Earth life, we will develop predictive tool ....Reconstruction of marine ecosystems following the greatest mass extinction during the Phanerozoic history of Earth life: Lessons for the present. Frequent defaunation events strongly threaten sustainable development of marine resources and human environments especially in countries that are surrounded by oceans such as Australia. By analysing recovery mechanisms of marine ecosystems following the Permian-Triassic mass extinction, the greatest crisis of Earth life, we will develop predictive tools for analysing restoration of modern marine defaunated ecosystems. Understanding biotic extinction and recovery is crucial to understanding the evolution of the Earth's biosphere. This study increases Australia's research profile on this global issue. The target strata are quality oil source rocks in Perth Basin, and thus this project is beneficial to the Australian petroleum industry.Read moreRead less
Extinction and survival: biotic responses to environmental change in Late Devonian oceans during a greenhouse-icehouse transition. This project represents an important opportunity to answer fundamental questions about the role of environmental changes in major mass extinction events in the geological past and to provide insight into the survival of modern marine species in response to climate change (National Research Priority 1). It will enhance Australia's global research profile in biostratig ....Extinction and survival: biotic responses to environmental change in Late Devonian oceans during a greenhouse-icehouse transition. This project represents an important opportunity to answer fundamental questions about the role of environmental changes in major mass extinction events in the geological past and to provide insight into the survival of modern marine species in response to climate change (National Research Priority 1). It will enhance Australia's global research profile in biostratigraphical and palaeontological research through contribution to the development of biozonations, correlation and global debate on extinction mechanisms. It will also strengthen international collaboration, and, importantly, provide crucial research training to young researchers in these fields.Read moreRead less
The early history of atmospheric oxygen. Atmospheric oxygen is essential for advanced life and its accumulation on the ancient Earth was accompanied by profound environmental, climatic and biological change. This project will clarify the complex interactions between the rise in atmospheric oxygen and changes in the Earth's surface environment, extreme climate change and biospheric evolution.