A Comprehensive Analysis Of The Role Of The Alcohol Dehydrogenase Gene Cluster In Alcohol-related Disorders And Esophageal Cancer Through Deep Resequencing
Funder
National Health and Medical Research Council
Funding Amount
$605,323.00
Summary
Excessive alcohol consumption remains a major public health concern in Australia where the burden of mental health disorders is dominated by substance-use disorders. Alcohol dehydrogenases (ADHs) are essential in the breakdown of alcohol in the body and we seek to resequence seven ADH genes with the aim to comprehensively catalogue and identify sequence variants that contribute to risk for consuming excessive quantities of alcohol, alcoholism and esophageal squamous cell carcinoma.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Discovery Early Career Researcher Award - Grant ID: DE140100553
Funder
Australian Research Council
Funding Amount
$392,570.00
Summary
Exploring links between climate change, ocean chemistry, and the rise of multicellular life: The Ediacaran sedimentary record of central Australia. For most of Earth’s history, single-celled organisms were the only forms of life on the planet. Not until roughly 600 million years ago do fossils of multicellular animals appear in the rock record. Explanations for the Ediacaran rise of multicellularity include extreme climate change, meteorite impact and oxygenation of the global ocean. Evaluation ....Exploring links between climate change, ocean chemistry, and the rise of multicellular life: The Ediacaran sedimentary record of central Australia. For most of Earth’s history, single-celled organisms were the only forms of life on the planet. Not until roughly 600 million years ago do fossils of multicellular animals appear in the rock record. Explanations for the Ediacaran rise of multicellularity include extreme climate change, meteorite impact and oxygenation of the global ocean. Evaluation of these hypotheses is complicated by the fact that stratigraphic records that span the appropriate time interval are rare. This project is focused on the carbon, oxygen, and zinc isotopic records preserved by Ediacaran marine rocks in the Amadeus Basin of central Australia. Results will contribute to a more complete record of fluctuations in ocean chemistry during a key interval of Earth history.Read moreRead less
New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages ....New Stratigraphy and Geostatistics for Gas and Water Resources . Management of gas and water resources is of significant importance to the Australian economy and society. Industry and government use digital modelling to assist in resources management. The first step in modelling is to correlate geological data and then use geostatistics to estimate properties in areas without data. This project aims to produce a new geological framework for the Surat Basin underpinned by new zircon ages and ages of fossils in sediments and a new geostatistical methodology to better represent flow properties in coal seams and aquifers. This is expected result in a more accurate modelling methodology that can be used by industry and government for modelling resources, including in other basins in Australia and worldwide.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100141
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality c ....High-resolution ITRAX XRF core scanning facility for global change research. This facility will enable researchers to obtain high-resolution geochemical profiles in the study of environmental change and climate variability. It will provide archive data on the variation of density and chemical element composition along sediment and soil cores, rock cores, wood samples, speleothems and corals. These archives contain important information such as human activity, climate variability, water quality changes, pollution histories, recent geomorphological change, land-use change, introduction of invasive species and the occurrence of bushfires. A better understanding of the occurrence and timing of these major environmental issues is of national and regional importance.Read moreRead less