Improving Long-term Mortality Rates Following Sepsis.
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
It is estimated that 37.9 million patients survive sepsis each year. Studies have demonstrated that among patients who survive for 30 days after admission for sepsis, over 40% die in the following two years. There are currently no guidelines that provide recommendations on post-hospital management of sepsis. This research programme aims to identify those patients at greatest risk of death and implement post-sepsis care with the aim to significantly reduce long-term mortality after sepsis.
Regulation Of Extrinsic Death Pathways In Neutrophils
Funder
National Health and Medical Research Council
Funding Amount
$84,656.00
Summary
During infection, the lifespan of neutrophils normally increases despite an abundance of neutrophil death signals in inflamed tissues. Altered lifespan of neutrophils has been reported in diseases associated with influenza, Streptococcus, RSV and cytomegalovirus infection. Our research has discovered a relationship between the two dominant death pathways in neutrophils, indicating that alterations in one death pathway protect the neutrophil from death signals from the second death pathway.
Improving Dosing Of Common Antibiotics Used In Critically Ill Australian Indigenous Patients
Funder
National Health and Medical Research Council
Funding Amount
$98,148.00
Summary
Optimal antibiotic dosing in patients in the intensive care unit saves lives. However, the way antibiotics move through the body of an intensive care unit patient can be different to other patients. Therefore, research that identifies specific dosing for these patients is essential. Further to this, no research in an Indigenous population is available. The aim of this research is to address this gap by developing optimal antibiotic doses for Indigenous Australians in the intensive care unit.