The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic wor ....The neural dynamics of real-time processing in the brain. The aim of this project is to investigate a new model for predictive coding of sensory processing in the brain in which the brain compensates for the time delays in neural transmission by maintaining a real-time temporal alignment of the neural activity. This results in a representation of sensory information that is aligned in time across the cortex, offering a new fundamental principle for how the brain functions in a highly dynamic world whose outcomes would provide a deeper understanding of brain function. It could also have profound significance for artificial intelligence and brain-inspired technologies, as well as benefit neural sensory prostheses and brain-machine interfaces.Read moreRead less
Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the ext ....Fairness in Natural Language Processing. Natural language processing (NLP) has achieved spectacular commercial successes in recent years, and has been deployed across an ever-increasing breadth of devices and application areas. At the same time, there has been stark evidence to indicate that naively-trained models amplify biases in training data, and perform inconsistently across text relating to different demographic groupings of individuals. This project aims to systematically quantify the extent of such biases, and develop models that are both more socially equitable, as well as less prone to expose private data in the learned representations. In doing so, it will make NLP more accessible to new populations of users, and remove socio-technological barriers to NLP uptake.Read moreRead less
Building a visual world: how brain circuits create and use representations. This project aims to demonstrate the presence, computation, and use of an invariant representation for texture structure. The proposed approach is interdisciplinary and combines image analysis, electrophysiology, optogenetics and computational modelling.
Expected outcomes of this project include learning how neurons encode properties of natural images, defining a novel computational tool for analysis of textures, and ne ....Building a visual world: how brain circuits create and use representations. This project aims to demonstrate the presence, computation, and use of an invariant representation for texture structure. The proposed approach is interdisciplinary and combines image analysis, electrophysiology, optogenetics and computational modelling.
Expected outcomes of this project include learning how neurons encode properties of natural images, defining a novel computational tool for analysis of textures, and new knowledge of how multiple brain areas work together to represent the visual world. This should provide significant benefits for the development of artificial visual systems, and impact on brain research broadly by increasing the number of tools available to predict complex representations at the cellular level.Read moreRead less
Natural form, aesthetics and the human brain. This project aims to study how the brain represents the emotion of aesthetic experience. This project will establish the characteristics of flowers and floral design that govern their appeal using large scale web based data collection, and identify the neural representation of floral beauty using integrative data analysis. Outcomes of the project are expected to help flower growers and designers with product planning, supporting industry sustainabili ....Natural form, aesthetics and the human brain. This project aims to study how the brain represents the emotion of aesthetic experience. This project will establish the characteristics of flowers and floral design that govern their appeal using large scale web based data collection, and identify the neural representation of floral beauty using integrative data analysis. Outcomes of the project are expected to help flower growers and designers with product planning, supporting industry sustainability. The project will also establish how the brain generates positive experience in response to our visual environment, promoting well-being by enabling informed visual design decisions.Read moreRead less
Redefining the immune landscape of the human ocular surface. At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Int ....Redefining the immune landscape of the human ocular surface. At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Integrating state-of-the-art techniques, we will advance understanding of immune regulation at the human ocular surface by comprehensively defining immune cell biology and dynamics. We will define the effect of age on immune cells in these tissues, and relationships between the tear proteome and cell behaviours.Read moreRead less
Cognitive Foundations of Fast Decision Making. This project aims to develop a new theory of fast decision making. In all walks of life, from the sports field to the battlefield, fast and accurate decisions are central to human performance. This project will develop and test mathematical models of the processes involved in making decisions with continuous choice sets and decisions requiring integration of multiple sources of information and decisions in which information varies over time. It is e ....Cognitive Foundations of Fast Decision Making. This project aims to develop a new theory of fast decision making. In all walks of life, from the sports field to the battlefield, fast and accurate decisions are central to human performance. This project will develop and test mathematical models of the processes involved in making decisions with continuous choice sets and decisions requiring integration of multiple sources of information and decisions in which information varies over time. It is expected to contribute to our understanding of factors that characterise and limit human performance in settings in which fast and accurate decisions are required. It is expected to benefit the design of systems and environments in which safety and efficiency depend on human decision making.Read moreRead less
Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior co ....Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior colliculus codes sensory information and ultimately drives behaviour. The outcomes will be of immediate benefit to scientists studying sensory processing and perceptual decision making, and will help keep Australia at the forefront of brain-inspired engineering and the neuroscience-based knowledge economy.Read moreRead less
Characterisation and Prevention of Vibration-Induced Drowsiness in Drivers. The present CIs have demonstrated that vibrational frequencies of 4-7 Hz entrain brainwaves associated with the onset of sleep. Our unpublished pilot data show that higher vibrational frequencies can restore alertness. Thus future vehicle design could dampen 3-8Hz vibrations while higher frequency vibrations could counteract drowsiness or stimulate alertness. This project aims to: i) develop novel equivalent drowsiness c ....Characterisation and Prevention of Vibration-Induced Drowsiness in Drivers. The present CIs have demonstrated that vibrational frequencies of 4-7 Hz entrain brainwaves associated with the onset of sleep. Our unpublished pilot data show that higher vibrational frequencies can restore alertness. Thus future vehicle design could dampen 3-8Hz vibrations while higher frequency vibrations could counteract drowsiness or stimulate alertness. This project aims to: i) develop novel equivalent drowsiness contours for the effects of physical vibration on driver drowsiness that will form the basis of a new industry standard for transportation safety; ii) develop an innovative vibration regime to improve alertness. This research will reduce transportation injuries and deaths by enabling the design of safer transport vehicles.Read moreRead less
Automated assessment of data quality in biological knowledge resources. This project aims to develop methods for identifying poor quality data in biological databases. Research in biomedicine is underpinned by massive databases of biological data. Data quality is largely managed through manual curation, but automated methods to assess quality are critically needed. This project expects to develop a suite of computational tools for assessing biological data quality, utilising an innovative approa ....Automated assessment of data quality in biological knowledge resources. This project aims to develop methods for identifying poor quality data in biological databases. Research in biomedicine is underpinned by massive databases of biological data. Data quality is largely managed through manual curation, but automated methods to assess quality are critically needed. This project expects to develop a suite of computational tools for assessing biological data quality, utilising an innovative approach based on network analysis of database record connectivity. These tools will enable quantifying data quality at scale. Researchers, evidence-based decision-makers in biomedicine, and the analytical or predictive tools that use this data will make more reliable inferences and decisions.Read moreRead less